2. Metabolic Enzyme/Protease
  3. Hexokinase Glucose-6-Phosphate Isomerase (GPI)
  4. 2-Deoxy-D-glucose 6-phosphate

2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive and 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a Ki value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the generation and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (2-Deoxy-D-glucose 6-phosphate disodium) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

2-Deoxy-D-glucose 6-phosphate

2-Deoxy-D-glucose 6-phosphate Chemical Structure

CAS No. : 3573-50-0

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Other Forms of 2-Deoxy-D-glucose 6-phosphate:

2-Deoxy-D-glucose 6-phosphate Related Antibodies

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Description

2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive and 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a Ki value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the generation and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research[1][2].

In Vitro

2-Deoxy-D-glucose 6-phosphate inhibits 2DG phosphorylation by bovine heart hexokinase via a competitive mechanism with ATP and non-competitive mechanism with 2DG, with an average inhibition constant (Ki) of 1.45 mM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Deoxy-D-glucose 6-phosphate Related Antibodies
Molecular Weight

244.14

Formula

C6H13O8P
CAS No.
SMILES

O=P(O)(O)OC[C@@H](O)[C@@H](O)[C@H](O)CC=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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2-Deoxy-D-glucose 6-phosphate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Deoxy-D-glucose 6-phosphate3573-50-0HexokinaseGlucose-6-Phosphate Isomerase (GPI)Glucose-6-Phosphate IsomeraseGPI/G6PIcell deathcancer cellshypoxic conditionsbovine heart hexokinaseglucose-6-phosphate isomerasemonomeric yeast hexokinasecancerglycolysisrat heartshexokinaseInhibitorinhibitorinhibit

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