2-Deoxy-D-glucose 6-phosphate
Based on 2 publication(s) in Google Scholar
2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive and 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a Ki value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the generation and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 3573-50-0
- Formula: C6H13O8P
- Molecular Weight:244.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) 2-Deoxy-D-glucose 6-phosphate
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Biological Activity
2-Deoxy-D-glucose 6-phosphate inhibits 2DG phosphorylation by bovine heart hexokinase via a competitive mechanism with ATP and non-competitive mechanism with 2DG, with an average inhibition constant (Ki) of 1.45 mM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3573-50-0
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Molecular Weight 244.14
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Formula C6H13O8P
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SMILES
O=P(O)(O)OC[C@@H](O)[C@@H](O)[C@H](O)CC=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Anal Chem
Streamlined Methods for Profiling Targeted Michael Acceptor Molecules Reveal Natural PTP1B Covalent Inhibitors. [Abstract]2025 Oct 1. PMID: 41035255 -
Toxicol Appl Pharmacol
Exploring the potential use of Caenorhabditis elegans as an animal model for evaluating chemical-induced intestinal dysfunction. [Abstract]2024 Dec:493:117140. PMID: 39500396
Purity & Documentation
References
[1]. Pajak B, et al. 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents. Int J Mol Sci. 2019;21(1):234. Published 2019 Dec 29. [Content Brief]
[2]. Chen W, et al. The inhibition of bovine heart hexokinase by 2-deoxy-D-glucose-6-phosphate: characterization by 31P NMR and metabolic implications. Biochimie. 1992;74(9-10):867-873. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Deoxy-D-glucose 6-phosphate Related Classifications
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