2-Deoxy-D-glucose 6-phosphate sodium
2-Deoxy-D-glucose 6-phosphate sodium is an ATP-competitive, 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a Ki value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate sodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the production and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate sodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate sodium can be used in cancer-related research.
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- Fòrmula: C6H12NaO8P
- Peso molecular:266.12
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
In Vitro
2-deoxy-D-glucose 6-phosphate sodium inhibits 2DG phosphorylation catalyzed by bovine heart hexokinase via competitive inhibition of ATP and non-competitive inhibition of 2DG, with an average inhibition constant of 1.45 mM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 266.12
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Fòrmula C6H12NaO8P
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SMILES
O=CC[C@H]([C@@H]([C@@H](COP(O)(O[Na])=O)O)O)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Chen W, et al. The inhibition of bovine heart hexokinase by 2-deoxy-D-glucose-6-phosphate: characterization by 31P NMR and metabolic implications. Biochimie. 1992;74(9-10):867-873. [Content Brief]
[2]. Pajak B, et al. 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents. Int J Mol Sci. 2019;21(1):234. Published 2019 Dec 29. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Deoxy-D-glucose 6-phosphate sodium Related Classifications
HY-139409B Related Classifications
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