1. Biochemical Assay Reagents
  2. Streptavidin

Streptavidin is a ∼60 kDa homotetramer. Streptavidin binds four molecules of biotin with the highest affinity. The binding affinity of biotin to streptavidin is one of the highest reported for a non-covalent interaction to date, with a KD ∼ 0.01 pM. Streptavidin has an immunosuppressive role.

For research use only. We do not sell to patients.

Streptavidin Chemical Structure

Streptavidin Chemical Structure

CAS No. : 9013-20-1

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Description

Streptavidin is a ∼60 kDa homotetramer. Streptavidin binds four molecules of biotin with the highest affinity. The binding affinity of biotin to streptavidin is one of the highest reported for a non-covalent interaction to date, with a KD ∼ 0.01 pM[1]. Streptavidin has an immunosuppressive role[2].

In Vitro

Streptavidin (2-200 μg/mL) significantly suppresses the proliferation of Lewis T cells to WF by 76%-83% compared with untreated responders[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Lewis T cells
Concentration: 2-200 μg/mL
Incubation Time:
Result: Inhibited the proliferation of Lewis T cells to WF stimulators by 76%-83% compared with untreated responders, lower concentrations of 0.1 and 0.2 μg/mL did not significantly inhibit T-cell proliferation.
In Vivo

Streptavidin (8-80 mg/kg) treatment is effective in prolonging rat cardiac allografts in the high-responder WF-to-Lewis combination[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lewis rats[2]
Dosage: 8, 12, 20, 40, 60, or 80 mg/kg
Administration: Administered IP for 5 consecutive days after transplantation was combined with a single dose of 0.5 mL antilymphocyte serum (ALS) on day 0
Result: Prolonged cardiac allograft survival from MST of 7.3±0.5 and 8.4±0.5 days in naive and ALS-treated controls, respectively, to 15±1, 20±3, 16±3, 17±3, and 23±2 days, respectively.
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Streptavidin]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

References
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Streptavidin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Streptavidin
Cat. No.:
HY-P3152
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