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Results for "

Hedgehog+pathway

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (5) Autophagy (3) DNA Methyltransferase (1) Drug Metabolite (1) Endogenous Metabolite (1) Hedgehog (14) Isotope-Labeled Compounds (2) Microtubule/Tubulin (2) Parasite (2) Reference Standards (3) Smo (4)
By Research Areas:	Cancer (18) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (1)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Screening Libraries

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10440

Vismodegib Maximum Cited Publications 51 Publications Verification GDC-0449	Hedgehog Autophagy	Neurological Disease Inflammation/Immunology Cancer
Vismodegib (GDC-0449) is a BBB-permeable and orally active *hedgehog* pathway inhibitor with an IC₅₀ of 3 nM. Vismodegib also inhibits P-gp, ABCG2 with IC₅₀ values of 3.0 μM and 1.4 μM, respectively .

HY-17595

Mebendazole 5+ Cited Publications	Parasite Apoptosis Microtubule/Tubulin	Infection Cancer
Mebendazole is a highly effective, broad-spectrum antihelmintic against nematode infestations. Mebendazole also exhibits inhibitory effect against glioblastoma multiforme (GBM), inhibits *Hedgehog* pathway and tubulin polymerization. Mebendazole is orally active and can cross CNS penetration .

HY-12316

20(S)-Hydroxycholesterol 3 Publications Verification 20α-Hydroxycholesterol	Smo Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Cancer
20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator that selectively targets the Smoothened (Smo) of the *Hedgehog* pathway with an EC₅₀ of ~30 μM (Hedgehog). 20(S)-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors (without inducing transcription of receptor genes in the Wnt pathway). 20(S)-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells and synergistically activates the Raf/MEK/ERK pathway with Simvastatin (HY-17502) to promote bone regeneration. 20(S)-Hydroxycholesterol can be used to study the mechanisms of developmental biology, oncology, bone, and angiogenesis .

HY-100036

MK-4101	Smo Apoptosis Hedgehog	Cancer
MK-4101 is a Smoothened (SMO) antagonist (IC₅₀ of 1.1 µM for 293 cells ) and also a potent inhibitor of the *hedgehog pathway* (IC₅₀ of 1.5 µM for mouse cells; IC₅₀ of 1 µM for KYSE180 oesophageal cancer cells). MK-4101 has robust antitumor activity that inhibits tumor cell proliferation and induces extensive apoptosis .

HY-117229

Sonidegib metabolite M48	Drug Metabolite	Cancer
Sonidegib metabolite M48 is the main circulating metabolite of Sonidegib. Sonidegib is a hedgehog pathway inhibitor. M48 showed a much longer T_max (60 h) than Sonidegib .

HY-15398C

3-epi-Vitamin D3 Epicholecalciferol	Hedgehog	Cancer
3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a *Hedgehog pathway* inhibitor with an IC₅₀ of 39.2 μM measured in U87MG cells .

HY-17595R

Mebendazole (Standard)	Reference Standards Parasite Apoptosis Microtubule/Tubulin	Infection Cancer
Mebendazole (Standard) is the analytical standard of Mebendazole. This product is intended for research and analytical applications. Mebendazole is a highly effective, broad-spectrum antihelmintic against nematode infestations. Mebendazole also exhibits inhibitory effect against glioblastoma multiforme (GBM), inhibits *Hedgehog* pathway and tubulin polymerization. Mebendazole is orally active and can cross CNS penetration .

HY-110326

Smo antagonist M25	Hedgehog Smo	Cancer
Smo antagonist M25 is a smoothened antagonist for inhibition of the hedgehog pathway.

HY-156814

HPP-9	Hedgehog	Cancer
HPP-9 is a Proteolysis-Targeting Chimeras （PROTACs） based on *Hedgehog* Pathway Inhibitor-1 (HPI-1), with the pIC₅₀ of 6.71, that can degrade BET bromodomains. HPP-9 has antitumor activity ^[1[.

HY-10440R

Vismodegib (Standard) GDC-0449 (Standard)	Reference Standards Hedgehog Autophagy	Cancer
Vismodegib (Standard) is the analytical standard of Vismodegib. This product is intended for research and analytical applications. Vismodegib (GDC-0449) is a BBB-permeable and orally active *hedgehog* pathway inhibitor with an IC₅₀ of 3 nM. Vismodegib also inhibits P-gp, ABCG2 with IC₅₀ values of 3.0 μM and 1.4 μM, respectively .

HY-175299

Hedgehog IN-11	Hedgehog Apoptosis DNA Methyltransferase	Cancer
Hedgehog IN-11 is an orally active *Hedgehog* inhibitor. Hedgehog IN-11 downregulates the expression of O6-methylguanine-DNA methyltransferase (MGMT) to impair the Temozolomide (TMZ) (HY-17364) resistance by inhibiting the Hedgehog pathway. Hedgehog IN-11 shows improved inhibition of cell migration and invasion, and induced cell apoptosis in TMZ-resistant GBM cell lines. Hedgehog IN-11 is predicted by computer simulation to have good blood-brain barrier penetration. Hedgehog IN-11 can be used for the study of glioblastoma (GBM) .

HY-153730

Hedgehog IN-5	Hedgehog	Inflammation/Immunology
Hedgehog IN-5 is an orally active small molecule inhibitor of the *hedgehog* pathway. Hedgehog IN-5 can be used for the research of fibrotic disease .

HY-153457

Hedgehog IN-3	Hedgehog	Cancer
Hedgehog IN-3 (compound 3) is a *hedgehog pathway* inhibitor (IC₅₀ = 0.01 µM). Hedgehog IN-3 can be used in cancer research .

HY-153456

Hedgehog IN-2	Hedgehog	Cancer
Hedgehog IN-2 (Compound 20) is an inhibitor of *Hedgehog* pathway with an IC₅₀ value less than 0.003 μM in C3H10T1/2 cells .

HY-W716916

Vismodegib-d7	Isotope-Labeled Compounds	Cancer
Vismodegib-d₇ is deuterium labeled Vismodegib. Vismodegib (GDC-0449) is an orally active *hedgehog* pathway inhibitor with an IC₅₀ of 3 nM. Vismodegib also inhibits P-gp, ABCG2 with IC₅₀ values of 3.0 μM and 1.4 μM, respectively .

HY-W705354

Vismodegib-d4	Isotope-Labeled Compounds Hedgehog Autophagy	Cancer
Vismodegib-d₄ is deuterium labeled Vismodegib. Vismodegib (GDC-0449) is an orally active *hedgehog* pathway inhibitor with an IC₅₀ of 3 nM. Vismodegib also inhibits P-gp, ABCG2 with IC₅₀ values of 3.0 μM and 1.4 μM, respectively .

HY-159511

Hedgehog IN-7	Hedgehog	Cancer
Hedgehog IN-7 (Compound 8g), a purine derivative, acts as an inhibitor of *Hedgehog, capable of reducing the expression of Hedgehog* genes and inhibiting *Hedgehog* signaling. Hedgehog IN-7 has significant cytotoxicity and selectivity towards the *Hedgehog* pathway-dependent pancreatic cancer cell Mia-PaCa-2 cells and can be used in the research of pancreatic cancer .

HY-P992409

MEDI-5304	Hedgehog	Cancer
MEDI-5304 is a *hedgehog pathway* inhibitor with human sonic hedgehog (SHH) K_D of 5.13 pmol/L, and human Indian hedgehog (IHH) K_D of 34.7 pmol/L. MEDI-5304 binds and neutralizes SHH and IHH, blocks downstream target gene transcription, inhibits osteoblast differentiation. MEDI-5304 can be used for the research of colon cancer .

HY-100036R

MK-4101 (Standard)	Smo Reference Standards Apoptosis Hedgehog	Cancer
MK-4101 (Standard) is the analytical standard of MK-4101 (HY-100036). This product is intended for research and analytical applications. MK-4101 is a Smoothened (SMO) antagonist (IC50 of 1.1 μM for 293 cells ) and also a potent inhibitor of the hedgehog pathway (IC50 of 1.5 μM for mouse cells; IC50 of 1 μM for KYSE180 oesophageal cancer cells). MK-4101 has robust antitumor activity that inhibits tumor cell proliferation and induces extensive apoptosis .

Cat. No.	Product Name

HY-L017

Stem Cell Signaling Compound Library	2,723 compounds
Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy. MCE owns a unique collection of 2,723 compounds that can be used for stem cell regulatory and signaling pathway research.

Stem Cell Signaling Compound Library

2,723 compounds

Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy.

MCE owns a unique collection of 2,723 compounds that can be used for stem cell regulatory and signaling pathway research.

Cat. No.	Product Name	Target	Research Area	Image