Hedgehog IN-7
Hedgehog IN-7 (Compound 8g), a purine derivative, acts as an inhibitor of Hedgehog, capable of reducing the expression of Hedgehog genes and inhibiting Hedgehog signaling. Hedgehog IN-7 has significant cytotoxicity and selectivity towards the Hedgehog pathway-dependent pancreatic cancer cell Mia-PaCa-2 cells and can be used in the research of pancreatic cancer.
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- Fòrmula: C27H27FN8
- Peso molecular:482.56
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
Hedgehog IN-7 (Compound 8g) demonstrates cytotoxicity against MIA-PaCa-2 cells (IC50 = 4.11 μM) while exhibiting no cytotoxicity against HEK293 cells (IC50 > 50 μM)[1].
Hedgehog IN-7 (48 h) inhibits Hedgehog signaling in NIH3T3 SHh-Light II cells with an IC50 value of 6.4 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 482.56
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Fòrmula C27H27FN8
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SMILES
N#CC1=CC=C(C2=C3N=CN(CC4CC4)C3=NC(NC5=CC=C(N6CCN(C)CC6)C(F)=C5)=N2)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hedgehog IN-7 Related Classifications
HY-159511 Related Classifications
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