1. Stem Cell/Wnt
  2. Hedgehog
  3. Hedgehog IN-5

Hedgehog IN-5 

Cat. No.: HY-153730
Handling Instructions

Hedgehog IN-5 is an orally active small molecule inhibitor of the hedgehog pathway. Hedgehog IN-5 can be used for the research of fibrotic disease.

For research use only. We do not sell to patients.

Hedgehog IN-5 Chemical Structure

Hedgehog IN-5 Chemical Structure

CAS No. : 1544681-93-7

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Description

Hedgehog IN-5 is an orally active small molecule inhibitor of the hedgehog pathway. Hedgehog IN-5 can be used for the research of fibrotic disease[1].

In Vivo

Modeling methods: Bleomycin (HY-108345) (3 mg/kg; Intratracheal injection for 8 days)-induced pulmonary fibrosis model in rats. Hedgehog IN-5 (5-30 mg/kg; Oral administration after 8 days of moulding; once daily for 2 weeks) inhibits the progression of pulmonary fibrosis induced by Bleomycin (HY-108345) in several pathological evaluation indexes in SD rat model of unilateral pulmonary fibrosis, significantly[1].
Modeling methods: CCL4 (dissolved in olive oil at a dose of 0.5 μL/g; Oral administration; Three times a week for four weeks)-induced liver fibrosis model in C57BL/6 mice. Hedgehog IN-5 (5-20 mg/kg; Oral administration on the day of moulding; Once a day for 4 weeks) exhibits a certain trend of inhibiting CCl4-induced liver fibrosis. And primarily manifests as a reduction in hepatocyte degeneration and necrosis, as well as a decrease in fibrotic area in CCL4-induced liver fibrosis model in C57BL/6 mice[1].
Hedgehog IN-5 (10-20 mg/kg, 20mg/kg (Combined with BIBF1120 (50 mg/kg); Oral administration; Once a day for 20 days) alone or in combination with BIBF1120 significantly inhibits bleomycin-induced lung tissue inflammation and fibrosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Unilateral pulmonary fibrosis in SD rat model[1]
Dosage: 5 mg/kg, 15 mg/kg, 30 mg/kg
Administration: Oral administration after 8 days of moulding; once daily for 2 weeks
Result: Reduced the scores of Bleomycin (HY-108345)-treated mice, significantly.
Collagen content in the lungs as well as myofibroblasts were quantified to assess the antifibrotic effect of Hedgehog IN-5, α-SMA protein percentage was significantly reduced with 30 mg/kg dose and collagen content was not significantly changed.
Animal Model: CCL4-induced liver fibrosis model in C57BL/6 mice[1]
Dosage: 5 mg/kg, 10 mg/kg, 20 mg/kg
Administration: Oral administration on the day of moulding; Once a day for four weeks
Result: Showed slow weight gain after one week and no significant weight gain after two weeks at the dose of 20 mg/kg.
Serum biochemical detection in peripheral blood showed that ALT and AST were significantly reduced but TBIL had no change at the dose of 20mg/kg.
Liver histopathological analysis showed that the liver injury score decreased and the fibrosis area of liver tissue decreased.
Molecular Weight

534.02

Formula

C27H31ClF3N5O

CAS No.
SMILES

FC(F)(C1=C(C(NC2=CC(C3=NC=C(C(C)C)N3)=C(C=C2)Cl)=O)C=CC(N4C[C@@H](N([C@@H](C4)C)C)C)=C1)F

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Hedgehog IN-5 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Hedgehog IN-5
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HY-153730
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