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Referencia número: HY-153456

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Hedgehog IN-2

Hedgehog IN-2 (Compound 20) is an inhibitor of Hedgehog pathway with an IC₅₀ value less than 0.003 μM in C3H10T1/2 cells.

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No. CAS: 1126365-74-9
Fòrmula: C₂₄H₂₂N₄O₂
Peso molecular:398.46

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Hedgehog IN-2 Chemical Structure

No. CAS: 1126365-74-9

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Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Hedgehog IN-2 (Compound 20) is an inhibitor of Hedgehog pathway with an IC₅₀ value less than 0.003 μM in C3H10T1/2 cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
C3H 10T1/2	EC₅₀	0.015 μM Compound: 11e	Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis	[PMID: 22704236]
NIH3T3	IC₅₀	0.0026 μM Compound: 11e	Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assay Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assay	[PMID: 22704236]

In Vitro

Hedgehog IN-2 (3 μM; 72 h) inhibits the Hedgehog pathway with an inhibition rate of 58.1% in C3H10T1/2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay^[1]

Cell Line:

C3H10T1/2 cells
Concentration:

3 μM
Incubation Time:

72 h
Result:

Inhibited the Hedgehog pathway with an inhibition rate of 58.1% in C3H10T1/2 cells.

Chemical Information

No. CAS 1126365-74-9
Peso molecular 398.46
Fòrmula C₂₄H₂₂N₄O₂
SMILES

O=C(C1=CC=C(C=C1)OCC2=NC=CC=C2)NC3=C(C)C=CC(C4=NC(C)=CN4)=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Dakin Leslie, et al. HETEROCYCLIC AMIDES USEFUL FOR THE TREATMENT OF CANCER AND PSORIASIS, USA, US20100311748A [P]. 12/09/2010

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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