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Cat. No.: HY-110326

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Smo antagonist M25

Smo antagonist M25 is a smoothened antagonist for inhibition of the hedgehog pathway.

For research use only. We do not sell to patients.

CAS No.: 1186293-14-0
Formula: C₂₃H₂₉N₃O₂
Molecular Weight:379.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Smo antagonist M25 Chemical Structure

CAS No.: 1186293-14-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Smo antagonist M25 is a smoothened antagonist for inhibition of the hedgehog pathway.

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	0.005 μM Compound: 25	Inhibition of BODIPY-cyclopamine to Smo in human HEK293 Flag-Smo cells in presence of 2% FCS Inhibition of BODIPY-cyclopamine to Smo in human HEK293 Flag-Smo cells in presence of 2% FCS	[PMID: 19540115]
Shh Light II	IC₅₀	0.005 μM Compound: 25	Antagonist activity against Smo signaling in mouse purmorphamine-induced Shh Light2 cells assessed as inhibition of Gli-dependent firefly luciferase activity Antagonist activity against Smo signaling in mouse purmorphamine-induced Shh Light2 cells assessed as inhibition of Gli-dependent firefly luciferase activity	[PMID: 19540115]

Chemical Information

CAS No. 1186293-14-0
Molecular Weight 379.50
Formula C₂₃H₂₉N₃O₂
SMILES

O=C(NCC1=CC=C2N(N=CC2=C1)C3=CC=CC=C3OC)C(CCC)CCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dessole G, Branca D, Ferrigno F, Kinzel O, Muraglia E, Palumbi MC, Rowley M, Serafini S, Steinkühler C, Jones P. Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4191-5. doi: 10.1016/j.bmcl.2009.05.112. Epub 2009 Jun 2. PMID: 19540115. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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