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Results for "

IKZF2 degradation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	IKZF Family (19) Casein Kinase (2) E3 Ligase Ligand-Linker Conjugates (1) HOXA (1) Interleukin Related (2) Ligands for E3 Ligase (4) Molecular Glues (17) NF-κB (1) Potassium Channel (1) PROTACs (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (2) Inflammation/Immunology (5)

Inhibitors & Agonists

Peptides

Targets Recommended: IKZF Family

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144998

NVP-DKY709 1 Publications Verification	IKZF Family Molecular Glues	Inflammation/Immunology Cancer
NVP-DKY709 is an orally active and selective *IKZF2* molecular glue degrader with the D_max and DC₅₀ of 53% and 4 nM, respectively. In addition, NVP-DKY709 can degrade IKZF4 (DC₅₀: 13 nM) and SALL4 (DC₅₀: 2 nM). NVP-DKY709 exerts anti-tumor activity by binding with CRBN to change conformation and recruit and degrade *IKZF2* .

HY-122542B

PPACK TFA 2 Publications Verification	Ligands for E3 Ligase Molecular Glues IKZF Family	Cardiovascular Disease
PPACK TFA is an orally active, selective molecular glue degrader targeting *IKZF2. Through a molecular glue mechanism, PPACK TFA binds to CRBN, recruits IKZF2* to form a ternary complex, and promotes its ubiquitination and proteasomal degradation. This further converts inhibitory regulatory T cells (T_reg) into effector-like T cells, enhances CD8 ⁺ T cell responses, and modulates the T_eff:T_reg balance. PPACK TFA also increases the production of the inflammatory cytokine IL-2 and reduces the suppressive activity of T_reg. PPACK TFA can be used in cancer immunotherapy research, and exhibits a synergistic effect when combined with immune checkpoint inhibitors such as anti-PD1 .

HY-173630

BMS-986449	Molecular Glues IKZF Family	Cancer
BMS-986449 is a potent and orally active CELMoD molecular glue and an *IKZF2/IKZF4* degrader. BMS-986449 targets the degradation of transcription factors Helios (IKZF2) and Eos (IKZF4) in regulatory T (Treg) cells. BMS-986449 redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos, reprogramming Treg cells and enhancing antitumor immunity. BMS-986449 is promising for research of advanced solid tumors .

HY-172931

DEG-35	Molecular Glues Casein Kinase IKZF Family	Cancer
DEG-35 is a CRBN-dependent, dual *IKZF2* and CK1α molecule glue degrader, with DC₅₀ values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. DEG-35 activates the p53 apoptosis pathway. DEG-35 can be used in the research for Acute Myeloid Leukemia (AML) .

HY-145776

ALV1	Molecular Glues Ligands for E3 Ligase IKZF Family Interleukin Related	Inflammation/Immunology Cancer
ALV1 is a molecular glue degrader for Ikaros (IKZF1) and Helios (IKZF2) with DC₅₀ of 2.5 nM and 10.3 nM respectively. ALV1 bind CRBN with an IC₅₀ of 0.55 μM, and induces CRBN-Helios dimerization. ALV1 can be used to study the properties and functions of regulatory T cells .

HY-159647A

(S,S)-PLX-4545	Molecular Glues IKZF Family	Cancer
(S,S)-PLX-4545 (Compound I) is an orally active and cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios). (S,S)-PLX-4545 can be used for the study of IKZF2-mediated diseases or disorders, such as proliferative diseases or disorders and/or cancer .

HY-122542A

PPACK dihydrochloride 2 Publications Verification Pebac; D-Phenylalanyl-prolyl-arginyl Chloromethyl Ketone; D-Phe-Pro-Arg-CH2Cl	Ligands for E3 Ligase Molecular Glues IKZF Family	Cardiovascular Disease
PPACK dihydrochloride is an orally active, selective molecular glue degrader targeting *IKZF2. Through a molecular glue mechanism, PPACK dihydrochloride binds to CRBN, recruits IKZF2* to form a ternary complex, and promotes its ubiquitination and proteasomal degradation. This further converts inhibitory regulatory T cells (T_reg) into effector-like T cells, enhances CD8 ⁺ T cell responses, and modulates the T_eff:T_reg balance. PPACK dihydrochloride also increases the production of the inflammatory cytokine IL-2 and reduces the suppressive activity of T_reg. PPACK dihydrochloride can be used in cancer immunotherapy research, and exhibits a synergistic effect when combined with immune checkpoint inhibitors such as anti-PD1 .

HY-159647

PLX-4545	Molecular Glues Ligands for E3 Ligase IKZF Family	Cancer
PLX-4545 is an orally active, selective molecular glue degrader targeting *IKZF2. Through a molecular glue mechanism, PLX-4545 binds to CRBN, recruits IKZF2* to form a ternary complex, and promotes its ubiquitination and proteasomal degradation. This further converts inhibitory regulatory T cells (T_reg) into effector-like T cells, enhances CD8 ⁺ T cell responses, and modulates the T_eff:T_reg balance. PLX-4545 also increases the production of the inflammatory cytokine IL-2 and reduces the suppressive activity of T_reg. PLX-4545 can be used in cancer immunotherapy research, and exhibits a synergistic effect when combined with immune checkpoint inhibitors such as anti-PD1 .

HY-173630A

(Rac)-BMS-986449	Molecular Glues IKZF Family	Cancer
(R)-BMS-986449 is the racemic mixture of BMS-986449 (HY-173630). BMS-986449 is a CELMoD molecular glue and an *IKZF2/IKZF4* degrader. BMS-986449 targets the degradation of transcription factors Helios (IKZF2) and Eos (IKZF4) in regulatory T (Treg) cells. BMS-986449 redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos, reprogramming Treg cells and enhancing antitumor immunity. BMS-986449 is promising for research of advanced solid tumors .

HY-159647B

(1S,2S,3R)-PLX-4545	Molecular Glues IKZF Family	Cancer
(1S,2S,3R)-PLX-4545 is the (1S,2S,3R) enantiomer of PLX-4545 (HY-159647). PLX-4545 is an orally active and selective cereblon-based molecular glue degrader of *IKZF2* (zinc finger transcription factor Helios). PLX-4545 can reprogram immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing anti-tumor immune responses .

HY-168615

MGD-28	IKZF Family Casein Kinase	Cancer
MGD-28 is a potent, orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC₅₀=3.8 nM), *IKZF2* (DC₅₀=56.3 nM), and IKZF3 (DC₅₀=7.1 nM) in a dose-dependent manner. In addition, MGD-4 also degrades CK1α (DC₅₀=7.8 nM). MGD-28 has antiproliferative activity and can be used in multiple myeloma research .

HY-172930

PVTX-405	Molecular Glues IKZF Family Potassium Channel	Inflammation/Immunology Cancer
PVTX-405 is a selective and oral active *IKZF2* molecular glue degrader with a DC₅₀ of 0.7 nM and a D_max of 91%. PVTX-405 enhances degradation efficiency, significantly reduces off-target degradation, and alleviates hERG inhibition with IC₅₀ of 48 µM. PVTX-405 significantly inhibits the growth of MC38 tumors, with greater synergistic anti-cancer efficacy in combination with immune checkpoint therapies (ICTs) (anti-PD1 or anti-LAG3) in the MC38 mouse tumor xenograft model using Crbn ^391V C57BL/6 mice .

HY-172882

IKZF2-degrader 1	Molecular Glues IKZF Family	Cancer
IKZF2-degrader 1 (Compound 31) is a *IKZF2* molecular glue degrader, with an DC₅₀ of 0.5 nM. IKZF2-degrader 1 has minimal CK1α degradation activity relatively (DC₅₀: 210 nM). IKZF2-degrader 1 can be used for research of IKZF2-dependent cancers .

HY-177754

IKZF2-degrader 3	Molecular Glues IKZF Family	Inflammation/Immunology
IKZF2-degrader 3 (compound 6) is a molecular glue IKZF2 degrader with a DC₅₀ of 2.0 nM .

HY-W1128213

IKZF2-degrader 2	Molecular Glues IKZF Family	Inflammation/Immunology Cancer
IKZF2-degrader 2 is a selective and orally active *IKZF2* molecular glue degrader with DC₅₀ values of 0.5 nM and 1.8 nM in HiBit and FACS. The IKZF2-degrader 2 mediates the ubiquitination and degradation of target proteins by recruiting the CRL4-CRBN E3 ubiquitin ligase. IKZF2-degrader 2 displays moderate degradation against SALL4 with a DC₅₀ of 9 nM but does not induce any significant degradation towards IKZF1, IKZF3, CK1α and GSPT1. IKZF2-degrader 2 can be used for the study of cancer immunology .

HY-168614

MGD-4	IKZF Family	Cancer
MGD-4 is an orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC₅₀=67.2 nM), *IKZF2* (DC₅₀=918.2 nM), and IKZF3 (DC₅₀=95.8 nM) in a dose-dependent manner. MGD-4 effectively inhibits the growth of multiple myeloma .

HY-182945

IKZF2-degrader 5	Molecular Glues IKZF Family HOXA Interleukin Related NF-κB	Cancer
IKZF2-degrader 5 is a highly efficient, highly selective, rapidly acting, and orally active *IKZF2* molecular glue degrader. IKZF2-degrader 5 induces IKZF2 degradation via the Cullin-CRBN-dependent pathway. IKZF2-degrader 5 promotes the production of pro-inflammatory IL-2. IKZF2-degrader 5 attenuates the immunosuppressive function of regulatory T cells (Tregs). IKZF2-degrader 5 triggers rapid, significant, and sustained *IKZF2* degradation in the spleen and thymus of mice. IKZF2-degrader 5 inhibits tumor growth. IKZF2-degrader 5 can be used for the research of B16F melanoma .

HY-185300

IKZF2-degrader 4	IKZF Family Molecular Glues	Cancer
IKZF2-degrader 4 (Page 650, third compound from the top in the right column) is an *IKZF2* Molecular glue degrader. IKZF2-degrader 4 degrades IKZF2 protein. IKZF2-degrader 4 can be used in the research of cancer .

HY-182799

IBA-12	PROTACs Molecular Glues IKZF Family	Cancer
IBA-12 is a *IKZF2* molecular glue/PROTAC degrader with a DC₅₀ of 276.2 nM (Jurkat cells) and 461.8 nM (Mino cells), and an IC₅₀ of 179.9 nM. IBA-12 binds to the canonical tryptophan triad pocket of CRBN to form a ternary complex with *IKZF2. IBA-12 induces IKZF2* degradation mediated by the CRBN-dependent ubiquitin-proteasome system, with no effect on other CRBN substrates. IBA-12 induces the production of interleukin-2 (IL-2) through degrading *IKZF2*. IBA-12 is applicable to cancer immunology research .

HY-182808

E3 Ligase Ligand-linker Conjugate 230	E3 Ligase Ligand-Linker Conjugates	Others
E3 Ligase Ligand-linker Conjugate 230 is an E3 ligase ligand-linker conjugate that can be used for the synthesis of PROTACs, such as IBA-12 (HY-182799) .

Cat. No.	Product Name	Target	Research Area

HY-122542B

PPACK TFA 2 Publications Verification	Ligands for E3 Ligase Molecular Glues IKZF Family	Cardiovascular Disease
PPACK TFA is an orally active, selective molecular glue degrader targeting *IKZF2. Through a molecular glue mechanism, PPACK TFA binds to CRBN, recruits IKZF2* to form a ternary complex, and promotes its ubiquitination and proteasomal degradation. This further converts inhibitory regulatory T cells (T_reg) into effector-like T cells, enhances CD8 ⁺ T cell responses, and modulates the T_eff:T_reg balance. PPACK TFA also increases the production of the inflammatory cytokine IL-2 and reduces the suppressive activity of T_reg. PPACK TFA can be used in cancer immunotherapy research, and exhibits a synergistic effect when combined with immune checkpoint inhibitors such as anti-PD1 .

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