Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
M1 microglia
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "M1 microglia" in MCE Product Catalog:
13
Category:
Amaranthaceae Plants Endogenous metabolite Disease Research Fields Inflammation/Immunology Achyranthes bidentata Steroids
Target:
Target:
Research Areas:
YL-365 is a potent and selective GPR34 antagonist with an IC50 of 17 nM. YL-365 binds to a portion of the orthosteric binding pocket of GPR34 and induces allosteric changes that stabilize the receptor in an inactive conformation. YL-365 down-regulates expression of the proinflammatory gene iNOS in M1 microglia and suppresses proinflammatory responses. YL-365 reduces mechanical allodynia in a dose-dependent manner in a mouse model of neuropathic pain. YL-365 can be used for the research of neuropathic pain .
Cat. No.: HY-N2909
CAS No.: 58115-31-4
Category:
Alkaloids Other Alkaloids Plants Umbelliferae Disease Research Fields Inflammation/Immunology Carphephorus corymbosus (Nutt.) Torr. & A.Gray
Target:
Cat. No.: HY-P4111
CAS No.: 1318232-11-9
Target:
Research Areas:
Cat. No.: HY-P11315
Target:
Research Areas:
Cat. No.: HY-155762
CAS No.: 2968412-77-1
Research Areas:
Anti-neuroinflammation agent 1 is a potent anti-neuroinflammation agent that regulates polarization BV2 microglia cells from M1 phenotype to M2 phenotype .
Cat. No.: HY-P992512
Target:
Research Areas:
Cat. No.: HY-182096
Cat. No.: HY-182096A
Cat. No.: HY-182096B
Cat. No.: HY-182096C
Cat. No.: HY-155949
CAS No.: 931305-29-2
Research Areas:
Bt354 is an orally active STAT3 inhibitor with IC50 values of 4.6 μM (DU145), 6.5 μM (MDA-MB-435) and 7.2 μM (MDA-MB-231), respectively. Bt354 induces cell cycle arrest and apoptosis, and downregulates epithelial-mesenchymal transition-related genes. Bt354 exhibits anti-angiogenic and anti-inflammatory activities, attenuates the polarization of M1 microglia and A1 astrocytes, suppresses inflammasome-related signaling pathways, and alleviates mechanical hyperalgesia and thermal hyperalgesia. Bt354 can be used in research related to glioblastoma multiforme, triple-negative breast cancer, prostate cancer and neuropathic pain .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
