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Results for "

MI-2

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

1

Isotope-Labeled Compounds

5

Antibodies

1

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12276
    MALT1 inhibitor MI-2
    Maximum Cited Publications
    7 Publications Verification

    		 MALT1 Cancer
    MALT1 inhibitor MI-2 is a MALT1 inhibitor (IC50=5.84 μM). MALT1 inhibitor MI-2 binds directly to MALT1, irreversibly suppresses protease function and is accompanied by NF-κB reporter activity suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation. MALT1 inhibitor MI-2 shows nontoxic to animals .
    MALT1 inhibitor MI-2
  • HY-15222
    Menin-MLL inhibitor MI-2
    4 Publications Verification

    		 Epigenetic Reader Domain Apoptosis Cancer
    Menin-MLL inhibitor MI-2 is a competitive and selective Menin-MLL interaction inhibitor with an IC50 value of 446 nM and a Ki value of 158 nM. Menin-MLL inhibitor MI-2 downregulates the expression of target genes such as HOXA9 and MEIS1, inhibits proliferation of leukemia cells and induces apoptosis and differentiation. Menin-MLL inhibitor MI-2 is proming for rasearch of MLL-rearranged acute leukemias (e.g., AML, ALL) .
    Menin-MLL inhibitor MI-2
  • HY-108350
    MI-2-2
    1 Publications Verification

    		 Epigenetic Reader Domain Cancer
    MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (Kd=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation .
    MI-2-2
  • HY-161344
    Z36-MP5

    		IFNAR Cancer
    Z36-MP5 is an Mi-2β-targeted inhibitor, with IC50 of 0.082 μM. Z36-MP5 can reduce Mi-2β ATPase activity and reactivates ISG transcription. Z36-MP5 can stimulate T-cell-mediated cytotoxicity .
    Z36-MP5
  • HY-175600
    MI-2-80

    		IKZF Family Casein Kinase Molecular Glues Cancer
    MI-2-80 is a molecular glue degrader. MI-2-80 induces proteins (such as IKZF1/3 and CSNK1A1) to bind to CRBN, promoting their ubiquitination and degradation .
    MI-2-80
  • HY-15222A
    Menin-MLL inhibitor MI-2 dihydrochloride

    		Epigenetic Reader Domain Apoptosis Cancer
    Menin-MLL inhibitor MI-2 dihydrochloride is a competitive and selective Menin-MLL interaction inhibitor with an IC50 value of 446 nM and a Ki value of 158 nM. Menin-MLL inhibitor MI-2 dihydrochloride downregulates the expression of target genes such as HOXA9 and MEIS1, inhibits proliferation of leukemia cells and induces apoptosis and differentiation. Menin-MLL inhibitor MI-2 dihydrochloride is proming for rasearch of MLL-rearranged acute leukemias (e.g., AML, ALL) .
    Menin-MLL inhibitor MI-2 dihydrochloride
  • HY-B1409S
    Isosorbide dinitrate-13C6

    ISDN-13C6

    		 NO Synthase Cardiovascular Disease
    Isosorbide dinitrate- 13C6 is the 13C labeled Isosorbide dinitrate . Isosorbide dinitrate (ISDN) is an NO donor that prevents LV remodeling and degradation of cardiac function following myocardial infarction (MI) .
    Isosorbide dinitrate-13C6
  • HY-W017982A
    CMIT/MIT (2.0-2.5% in water)

    CMI/MI (2.0-2.5% in water)

    		 Biochemical Assay Reagents Inflammation/Immunology
    CMIT/MIT (CMI/MI) 2.0-2.5% in water is a highly effective preservative, wiht also a skin sensitizing effect. Some regions stipulate that the concentration of CMIT/MIT used must not exceed 0.0015%, and it is prohibited from being used in other cosmetics .
    CMIT/MIT (2.0-2.5% in water)
  • HY-134921
    MI-nc dihydrochloride

    		Epigenetic Reader Domain Cancer
    MI-nc dihydrochloride is a weak inhibitor of the Menin-MLL fusion protein interaction with an IC50 of 193 μM. MI-nc dihydrochloride can be used as a negative control compound of MI-2 .
    MI-nc dihydrochloride
  • HY-108350R
    MI-2-2 (Standard)

    		Reference Standards Epigenetic Reader Domain Cancer
    MI-2-2 (Standard) is the analytical standard of MI-2-2 (HY-108350). This product is intended for research and analytical applications. MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (Kd=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation .
    MI-2-2 (Standard)
  • HY-RS25407
    Chd4 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Chd4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Chd4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Chd4 Rat Pre-designed siRNA Set A
    Chd4 Rat Pre-designed siRNA Set A

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