Menin-MLL inhibitor MI-2 dihydrochloride
Based on 4 publication(s) in Google Scholar
Menin-MLL inhibitor MI-2 dihydrochloride is a competitive and selective Menin-MLL interaction inhibitor with an IC50 value of 446 nM and a Ki value of 158 nM. Menin-MLL inhibitor MI-2 dihydrochloride downregulates the expression of target genes such as HOXA9 and MEIS1, inhibits proliferation of leukemia cells and induces apoptosis and differentiation. Menin-MLL inhibitor MI-2 dihydrochloride is proming for rasearch of MLL-rearranged acute leukemias (e.g., AML, ALL).
For research use only. We do not sell to patients.
- Formula: C18H27Cl2N5S2
- Molecular Weight:448.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Menin-MLL inhibitor MI-2 dihydrochloride
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Biological Activity
Description
Chemical Information
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Molecular Weight 448.48
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Formula C18H27Cl2N5S2
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SMILES
CCCC1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(C)(S4)C.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Cell Syst
A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations. [Abstract]2018 Apr 25;6(4):424-443.e7. PMID: 29655704 -
Molecules
Modulatory Effect of Curcumin on Expression of Methyltransferase/Demethylase in Colon Cancer Cells: Impact on wt p53, mutp53 and c-Myc. [Abstract]2025 Jul 22;30(15):3054. PMID: 40807229 -
Oncol Lett
Mucosa‑associated lymphoid tissue lymphoma translocation protein 1 inhibitor, MI‑2, attenuates non‑small cell lung cancer cell proliferation, migration and invasion, and promotes apoptosis by suppressing the JNK/c‑JUN pathway. [Abstract]2024 Jul 30;28(4):465. PMID: 39119234 -
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Menin-MLL inhibitor MI-2 dihydrochloride Related Classifications
HY-15222A Related Classifications
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