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Cat. No.: HY-134921

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MI-nc dihydrochloride

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MI-nc dihydrochloride is a weak inhibitor of the Menin-MLL fusion protein interaction with an IC₅₀ of 193 μM. MI-nc dihydrochloride can be used as a negative control compound of MI-2.

For research use only. We do not sell to patients.

Purity: 99.9%
CAS No.: 1934302-23-4
Formula: C₁₄H₁₈Cl₂N₆S₂
Molecular Weight:405.37

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

MI-nc dihydrochloride Chemical Structure

CAS No.: 1934302-23-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

MI-nc dihydrochloride is a weak inhibitor of the Menin-MLL fusion protein interaction with an IC₅₀ of 193 μM. MI-nc dihydrochloride can be used as a negative control compound of MI-2^[1].

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Chemical Information

CAS No. 1934302-23-4
Appearance Solid
Molecular Weight 405.37
Formula C₁₄H₁₈Cl₂N₆S₂
Color Off-white to light yellow
SMILES

CCC1=CC2=C(N3CCN(C4=NN=CS4)CC3)N=CN=C2S1.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Grembecka J, et al. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat Chem Biol. 2012;8(3):277-284. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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MI-nc dihydrochloride

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Biological Activity

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Calculators

Help & FAQs

MI-nc dihydrochloride Related Classifications

HY-134921 Related Classifications