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Results for "

MTH1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (9)
By Research Areas:	Cancer (8)

12

Inhibitors & Agonists

1

Natural
Products

1

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

BAY-707	DNA/RNA Synthesis	Cancer
BAY-707 is a substrate-competitive, highly potent and selective inhibitor of *MTH1(NUDT1)* with an IC₅₀ of 2.3 nM. BAY-707 has a good pharmacokinetic (PK) profile to other MTH1 compounds and is well-tolerated in mice, but shows a clear lack of in vitro or in vivo anticancer efficacy ^[1].

(S)-Crizotinib
(S)-Crizotinib is a potent and selective MTH1 (mutT homologue) inhibitor with an IC₅₀ of 330 nM. (S)-Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single strand breaks, activates DNA repair in human colon carcinoma cells, and effectively suppresses tumour growth in animal models ^[1].

MTH1-IN-2	DNA/RNA Synthesis	Cancer
MTH1-IN-2 is a MutT homolog 1 (MTH1) inhibitor extracted from patent WO2016135138A1, Compound (6), MTH1-IN-2 can be used for the research of cancer. Anti-tumor activity ^[1].

aTAG 2139 CFT-2139	DNA/RNA Synthesis	Others
aTAG 2139 (CFT-2139) is an aTAG-based *MTH1* fusion protein degrader with a DC₅₀ value of 1.1 nM. aTAG 2139 has a Ki value of 2.1 nM for MTH1 ^[1].

aTAG 4531 CFT-4531	DNA/RNA Synthesis	Cancer
aTAG 4531 (CFT-4531) is a potent, selective, and onmechanism tool degrader of *MTH1* with DC₅₀ value of 0.28 nM and K_i value of 1.8 nM. degradation activity is due to the intricate formation of the ternary complex between the MTH1 aTAG, CRBN E3 ligase, and aTAG tool degrader ^[1].

TH287 2 Publications Verification	DNA/RNA Synthesis	Cancer
TH287 is a potent and selective inhibitor of *MTH1, with an IC₅₀* of 0.8 nM. TH287 is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 could act as a chemotherapeutic agent for cancer research ^[1].

TH287 hydrochloride	DNA/RNA Synthesis	Cancer
TH287 hydrochloride is a potent and selective inhibitor of *MTH1, with an IC₅₀* of 0.8 nM. TH287 hydrochloride is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 hydrochloride could act as a chemotherapeutic agent for cancer research ^[1].

TH588 1 Publications Verification	DNA/RNA Synthesis	Cancer
TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the *MTH1* (IC₅₀= 5 nM).

HY-12814A

TH588 hydrochloride

TH588 hydrochloride is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC₅₀= 5 nM).

TH5427 hydrochloride	DNA/RNA Synthesis	Cancer
TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC₅₀=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells ^[1].

aTAG 2139-NEG	Others	Others
aTAG 2139-NEG (Compound 23) binds to MTH1 and has no degradative activity with a Ki value of 2.0 nM. aTAG 2139-NEG serves as aTAG 2139 negative control ^[1].

3-Isomangostin	DNA/RNA Synthesis	Cancer
3-Isomangostin, extracted from Garciniamangostana.L. shell, is a potent MutT homologue 1 (MTH1) inhibitor with an IC₅₀ value of 52 nM. 3-Isomangostin would be an attractive chemical tool for the development of anticancer agents ^[1].

Cat. No.	Compare	Product Name	Species	Source

	MTH1 Protein, Human (His) Oxidized purine nucleoside triphosphate hydrolase; Nudix motif 1; NUDT1; MTH1	Human	E. coli
	The MTH1 protein functions as an oxidative purine nucleoside triphosphohydrolase and is essential for the protection of cellular nucleotide pools. It catalyzes the hydrolysis of oxidized purine nucleoside triphosphates (such as 2-oxo-dATP and 8-oxo-dGTP), preventing their incorporation into DNA and avoiding base pair transversions. MTH1 Protein, Human (His) is the recombinant human-derived MTH1 protein, expressed by E. coli , with N-His labeled tag. The total length of MTH1 Protein, Human (His) is 156 a.a., with molecular weight of ~20.2 kDa.

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