Cat. No.: HY-N6845

3-Isomangostin

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Based on 1 Customer Validation

3-Isomangostin, extracted from Garciniamangostana.L. shell, is a potent MutT homologue 1 (MTH1) inhibitor with an IC₅₀ value of 52 nM. 3-Isomangostin would be an attractive chemical tool for the development of anticancer agents.

For research use only. We do not sell to patients.

Purity: 99.70%
CAS No.: 19275-46-8
Formula: C₂₄H₂₆O₆
Molecular Weight:410.46

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

3-Isomangostin Chemical Structure

CAS No.: 19275-46-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
ASPC1	IC₅₀	>100 μM Compound: 12b	Cytotoxicity against human AsPC1 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against human AsPC1 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]
B16-F10	IC₅₀	>100 μM Compound: 12b	Cytotoxicity against mouse B16F10 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against mouse B16F10 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]
HeLa S3	IC₅₀	>10 μM Compound: 28	Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
HepG2	IC₅₀	>10 μM Compound: 28	Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
HT-29	ED₅₀	4.9 μM Compound: 4	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 19839614]
HT-29	IC₅₀	>10 μM Compound: 28	Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
KB	IC₅₀	>10 μM Compound: 28	Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
MCF7	IC₅₀	>10 μM Compound: 28	Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
MDA-MB-231	IC₅₀	>100 μM Compound: 12b	Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]
NCI-H460	IC₅₀	>100 μM Compound: 12b	Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]
SW-620	IC₅₀	>100 μM Compound: 12b	Cytotoxicity against human SW620 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against human SW620 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]

Chemical Information

CAS No. 19275-46-8
Appearance Solid
Molecular Weight 410.46
Formula C₂₄H₂₆O₆
Color Off-white to light yellow
SMILES

C/C(C)=C\CC1=C2C(OC3=C(C(O)=C4C(OC(C)(C)CC4)=C3)C2=O)=CC(O)=C1OC
Structure Classification
- Phenols
- Polyphenols
- Phenols
- Xanthones
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (243.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4363 mL

12.1815 mL

24.3629 mL

5 mM

0.4873 mL

2.4363 mL

4.8726 mL

10 mM

0.2436 mL

1.2181 mL

2.4363 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (6.09 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (6.09 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yokoyama T, et al. Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening. Eur J Med Chem. 2019 Apr 1;167:153-160. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4363 mL	12.1815 mL	24.3629 mL	60.9073 mL
	5 mM	0.4873 mL	2.4363 mL	4.8726 mL	12.1815 mL
	10 mM	0.2436 mL	1.2181 mL	2.4363 mL	6.0907 mL
	15 mM	0.1624 mL	0.8121 mL	1.6242 mL	4.0605 mL
	20 mM	0.1218 mL	0.6091 mL	1.2181 mL	3.0454 mL
	25 mM	0.0975 mL	0.4873 mL	0.9745 mL	2.4363 mL
	30 mM	0.0812 mL	0.4060 mL	0.8121 mL	2.0302 mL
	40 mM	0.0609 mL	0.3045 mL	0.6091 mL	1.5227 mL
	50 mM	0.0487 mL	0.2436 mL	0.4873 mL	1.2181 mL
	60 mM	0.0406 mL	0.2030 mL	0.4060 mL	1.0151 mL
	80 mM	0.0305 mL	0.1523 mL	0.3045 mL	0.7613 mL
	100 mM	0.0244 mL	0.1218 mL	0.2436 mL	0.6091 mL

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3-Isomangostin

Cell Cycle/DNA Damage Compound Library

Natural Product Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Phenols Library

Traditional Chinese Medicine Active Compound Library

Food-Sourced Compound Library

Anti-Cancer Natural Product Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Metabolite Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

3-Isomangostin

Cell Cycle/DNA Damage Compound Library

Natural Product Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Phenols Library

Traditional Chinese Medicine Active Compound Library

Food-Sourced Compound Library

Anti-Cancer Natural Product Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Metabolite Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

3-Isomangostin Related Classifications

Cat. No.: HY-N6845