1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. TH588 hydrochloride

TH588 hydrochloride 

Cat. No.: HY-12814A
Handling Instructions

TH588 hydrochloride is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM).

For research use only. We do not sell to patients.

TH588 hydrochloride Chemical Structure

TH588 hydrochloride Chemical Structure

CAS No. : 1640282-30-9

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Description

TH588 hydrochloride is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM).

In Vitro

TH588 (2-10μM; 7-10 days) selectively and effectively kills U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC50s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: U2OS, HeLa, MDA-MB-231, MCF-7, SW480, SW620, VH10, HDFn cells
Concentration: 2, 4, 6, 8, 10 μM
Incubation Time: 7–10 days
Result: Selectively and effectively killed U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC50s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM, respectively, but was less toxic to several primary or immortalized cells.
In Vivo

TH588 (30 mg/kg; s.c.; once daily for 35 days) reduces tumour growth in SW480 xenograft cancer model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5-6 weeks female SCID mice (SW480 xenograft cancer model)[1]
Dosage: 30 mg/kg
Administration: Subcutaneous injection (s.c.); once daily for 35 days
Result: Reduced tumour growth in SW480 xenograft cancer model.
Molecular Weight

331.63

Formula

C₁₃H₁₃Cl₃N₄

CAS No.

1640282-30-9

SMILES

NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC3CC3)=N1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TH588TH 588TH-588DNA/RNA SynthesisInhibitorinhibitorinhibit

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TH588 hydrochloride
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HY-12814A
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