1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis

TH588 

Cat. No.: HY-12814 Purity: 99.06%
Handling Instructions

TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1(IC50= 5 nM) in cells.

For research use only. We do not sell to patients.

TH588 Chemical Structure

TH588 Chemical Structure

CAS No. : 1609960-31-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
25 mg USD 168 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 288 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 528 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of TH588:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1(IC50= 5 nM) in cells. IC50 value: 5 nM [1] Target: MTH1 inhibitor TH588 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family or a panel of 87 enzymes, GPCRs, kinases, ion channels and transporter. TH588 has been shown to selectively kill a variety of cancer cell lines and with in vivo activity shown for TH588 in SW480 colorectal and MCF7 breast tumour xenografts.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.3879 mL 16.9394 mL 33.8788 mL
5 mM 0.6776 mL 3.3879 mL 6.7758 mL
10 mM 0.3388 mL 1.6939 mL 3.3879 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

295.17

Formula

C₁₃H₁₂Cl₂N₄

CAS No.

1609960-31-7

SMILES

NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC3CC3)=N1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 16 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
TH588
Cat. No.:
HY-12814
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