1. Cell Cycle/DNA Damage
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  3. TH287 hydrochloride

TH287 hydrochloride 

Cat. No.: HY-16965A
Handling Instructions

TH287 hydrochloride is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 hydrochloride is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 hydrochloride could act as a chemotherapeutic agent for cancer research.

For research use only. We do not sell to patients.

TH287 hydrochloride Chemical Structure

TH287 hydrochloride Chemical Structure

CAS No. : 1638211-05-8

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Description

TH287 hydrochloride is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 hydrochloride is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 hydrochloride could act as a chemotherapeutic agent for cancer research[1].

IC50 & Target

IC50: 0.8 nM (MTH1)[1]

In Vitro

TH287 (1-10 μM; 24 h) selectively and effectively kills U2OS and other cancer cell lines, but is considerably less toxic to several primary or immortalized cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TH287 (5 mg/kg; i.p.) exhibits Cmax of 0.82 μM and tmax of 0.5 h in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

305.59

Formula

C₁₁H₁₁Cl₃N₄

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
TH287 hydrochloride
Cat. No.:
HY-16965A
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