1638211-05-8
Chemical Structure
TH287 hydrochloride
- CAS No.: 1638211-05-8
- Formula:C11H11Cl3N4
- Molecular Weight:305.59
IUPAC Name: 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine hydrochloride
InChIKey: YBLIJWDQSUDCJU-UHFFFAOYSA-N
SMILES: NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1.[H]Cl
Biological Activity: TH287 hydrochloride is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 hydrochloride is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 hydrochloride could act as a chemotherapeutic agent for cancer research[1].
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TH287 hydrochloride | TH287 hydrochloride is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 hydrochloride is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 hydrochloride could act as a chemotherapeutic agent for cancer research. | |||||||||||||||||||||
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Keywords
