1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. TH287

TH287 

Cat. No.: HY-16965 Purity: 98.14%
Handling Instructions

TH287 is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 could act as a chemotherapeutic agent for cancer research.

For research use only. We do not sell to patients.

TH287 Chemical Structure

TH287 Chemical Structure

CAS No. : 1609960-30-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 83 In-stock
Estimated Time of Arrival: December 31
5 mg USD 75 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 480 In-stock
Estimated Time of Arrival: December 31
100 mg USD 800 In-stock
Estimated Time of Arrival: December 31
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500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of TH287:

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Description

TH287 is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 could act as a chemotherapeutic agent for cancer research[1].

IC50 & Target

IC50: 0.8 nM (MTH1)[1]

In Vitro

TH287 (1-10 μM; 24 h) selectively and effectively kills U2OS and other cancer cell lines, but is considerably less toxic to several primary or immortalized cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TH287 (5 mg/kg; i.p.) exhibits Cmax of 0.82 μM and tmax of 0.5 h in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

269.13

Formula

C₁₁H₁₀Cl₂N₄

CAS No.

1609960-30-6

SMILES

NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (371.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7157 mL 18.5784 mL 37.1568 mL
5 mM 0.7431 mL 3.7157 mL 7.4314 mL
10 mM 0.3716 mL 1.8578 mL 3.7157 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.29 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.29 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TH287TH 287TH-287DNA/RNA SynthesisInhibitorinhibitorinhibit

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TH287
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HY-16965
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