1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis

TH287 

Cat. No.: HY-16965 Purity: 97.62%
Handling Instructions

TH287 is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.

For research use only. We do not sell to patients.

TH287 Chemical Structure

TH287 Chemical Structure

CAS No. : 1609960-30-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 83 In-stock
Estimated Time of Arrival: December 31
5 mg USD 75 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 480 In-stock
Estimated Time of Arrival: December 31
100 mg USD 800 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of TH287:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

TH287 is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16. IC50 value: 0.8 nM [1] Target: MTH1 inhibitor TH287 is considered a new target for cancer therapy. TH287 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family. TH287 has been shown to selectively kill a variety of cancer cell lines, but is rapidly metablized, so not as useful for in vivo studies.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 2.7 mg/mL (10.03 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7157 mL 18.5784 mL 37.1568 mL
5 mM 0.7431 mL 3.7157 mL 7.4314 mL
10 mM 0.3716 mL 1.8578 mL 3.7157 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

269.13

Formula

C₁₁H₁₀Cl₂N₄

CAS No.

1609960-30-6

SMILES

NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
TH287
Cat. No.:
HY-16965
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TH287

Cat. No.: HY-16965