1609960-30-6

TH287 Chemical Structure
1609960-30-6

Chemical Structure

TH287

  • CAS No.: 1609960-30-6
  • Formula:C11H10Cl2N4
  • Molecular Weight:269.13

IUPAC Name: 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine

InChIKey: URWCXPXBBITYLR-UHFFFAOYSA-N

SMILES: NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1

Biological Activity: TH287 is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 could act as a chemotherapeutic agent for cancer research[1].

Cat. No. Product Name Purity Description Pricing
HY-16965 		TH287 98.99% TH287 is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 could act as a chemotherapeutic agent for cancer research.
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