2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. MTH1-IN-2

MTH1-IN-2 is a MutT homolog 1 (MTH1) inhibitor extracted from patent WO2016135138A1, Compound (6), MTH1-IN-2 can be used for the research of cancer. Anti-tumor activity.

For research use only. We do not sell to patients.

MTH1-IN-2 Chemical Structure

MTH1-IN-2 Chemical Structure

CAS No. : 901044-91-5

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MTH1-IN-2 Related Antibodies

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Description

MTH1-IN-2 is a MutT homolog 1 (MTH1) inhibitor extracted from patent WO2016135138A1, Compound (6), MTH1-IN-2 can be used for the research of cancer. Anti-tumor activity[1].

IC50 & Target

MTH1[1]
In Vitro

The enzyme human MTH1 is a 2-hydroxy-dATP diphosphatase. MTH1 specifically assists RAS-induced tumors in preventing tumor- suppressive effects such as senescence whilst enabling maintenance and progression of the tumor. MTH1 inhibition helps impairing tumor growth by abrogating mitogenic signaling, epithelial-mesenchymal transition (EMT), a hallmark of progressing and aggressive tumors, anoikis inhibition and PI3K/Akt-mediated pro-survival signaling. MTH1 inhibitors induce oxidative DNA lesions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MTH1-IN-2 Related Antibodies
Molecular Weight

469.55

Formula

C24H27N3O5S
CAS No.
SMILES

O=C(C1=CNC2=C(C=C(S(=O)(NC3=CC=CC(OC)=C3)=O)C=C2)C1=O)NC4C(C)CCCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MTH1-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MTH1-IN-2901044-91-5DNA/RNA SynthesisMutThomologMTH1cancerRASEMTDNAInhibitorinhibitorinhibit

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