1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. MTH1-IN-2

MTH1-IN-2 

Cat. No.: HY-135967
Handling Instructions

MTH1-IN-2 is a MutT homolog 1 (MTH1) inhibitor extracted from patent WO2016135138A1, Compound (6), MTH1-IN-2 can be used for the research of cancer. Anti-tumor activity.

For research use only. We do not sell to patients.

MTH1-IN-2 Chemical Structure

MTH1-IN-2 Chemical Structure

CAS No. : 901044-91-5

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Description

MTH1-IN-2 is a MutT homolog 1 (MTH1) inhibitor extracted from patent WO2016135138A1, Compound (6), MTH1-IN-2 can be used for the research of cancer. Anti-tumor activity[1].

IC50 & Target

MTH1[1]

In Vitro

The enzyme human MTH1 is a 2-hydroxy-dATP diphosphatase. MTH1 specifically assists RAS-induced tumors in preventing tumor- suppressive effects such as senescence whilst enabling maintenance and progression of the tumor. MTH1 inhibition helps impairing tumor growth by abrogating mitogenic signaling, epithelial-mesenchymal transition (EMT), a hallmark of progressing and aggressive tumors, anoikis inhibition and PI3K/Akt-mediated pro-survival signaling. MTH1 inhibitors induce oxidative DNA lesions[1].

Molecular Weight

469.55

Formula

C₂₄H₂₇N₃O₅S

CAS No.

901044-91-5

SMILES

O=C(C1=CNC2=C(C=C(S(=O)(NC3=CC=CC(OC)=C3)=O)C=C2)C1=O)NC4C(C)CCCC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

MTH1-IN-2DNA/RNA SynthesisMutThomologMTH1cancerRASEMTDNAInhibitorinhibitorinhibit

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