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Cat. No.: HY-163168

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aTAG 4531

(Synonyms: CFT-4531)

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Based on 1 Customer Validation

aTAG 4531 (CFT-4531) is a potent, selective, and onmechanism tool degrader of MTH1 with DC₅₀ value of 0.28 nM and K_i value of 1.8 nM. The degradation activity is due to the intricate formation of the ternary complex between the MTH1 aTAG, CRBN E3 ligase, and aTAG tool degrader.
(Pink: MTH1 ligand (HY-134725); Blue: Cereblon ligand (HY-126457); Black: linker (HY-108374)).

For research use only. We do not sell to patients.

Purity: 99.1%
CAS No.: 2412985-00-1
Formula: C₄₆H₃₉F₂N₉O₇
Molecular Weight:867.85

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

aTAG 4531 Chemical Structure

CAS No.: 2412985-00-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

aTAG 4531 (CFT-4531) is a potent, selective, and onmechanism tool degrader of MTH1 with DC₅₀ value of 0.28 nM and K_i value of 1.8 nM. The degradation activity is due to the intricate formation of the ternary complex between the MTH1 aTAG, CRBN E3 ligase, and aTAG tool degrader^[1]. (Pink: MTH1 ligand (HY-134725); Blue: Cereblon ligand (HY-126457); Black: linker (HY-108374)).

All PROTACs Isoforms :

All DNA/RNA Synthesis Isoforms :

Chemical Information

CAS No. 2412985-00-1
Appearance Solid
Molecular Weight 867.85
Formula C₄₆H₃₉F₂N₉O₇
Color White to off-white
SMILES

O=C(C1=C(F)C=C(C2=CC3=C(NC4=CC=CC=C4)C(C(NC5CC5)=O)=CN=C3C=C2F)C=C1)NCCCCN6N=NC(COC7=CC=CC(C(N8C9C(NC(CC9)=O)=O)=O)=C7C8=O)=C6
Synonyms

CFT-4531
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Veits G K, et al. Development of an AchillesTAG degradation system and its application to control CAR-T activity [J]. Current Research in Chemical Biology, 2021, 1: 100010.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
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Chemical Information
Purity & Documentation
References

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aTAG 4531

All PROTACs Isoforms

All DNA/RNA Synthesis Isoforms