2412985-00-1
2412985-00-1
Chemical Structure
aTAG 4531
Synonym(s): CFT-4531
- CAS No.: 2412985-00-1
- Formula:C46H39F2N9O7
- Molecular Weight:867.85
InChIKey: BNHRIFMLKOQTPS-UHFFFAOYSA-N
SMILES: O=C(C1=C(F)C=C(C2=CC3=C(NC4=CC=CC=C4)C(C(NC5CC5)=O)=CN=C3C=C2F)C=C1)NCCCCN6N=NC(COC7=CC=CC(C(N8C9C(NC(CC9)=O)=O)=O)=C7C8=O)=C6
Biological Activity: aTAG 4531 (CFT-4531) is a potent, selective, and onmechanism tool degrader of MTH1 with DC50 value of 0.28 nM and Ki value of 1.8 nM. The degradation activity is due to the intricate formation of the ternary complex between the MTH1 aTAG, CRBN E3 ligase, and aTAG tool degrader[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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aTAG 4531 | 99.1% | aTAG 4531 (CFT-4531) is a potent, selective, and onmechanism tool degrader of MTH1 with DC50 value of 0.28 nM and Ki value of 1.8 nM. The degradation activity is due to the intricate formation of the ternary complex between the MTH1 aTAG, CRBN E3 ligase, and aTAG tool degrader. | ||||||||||||||||||||
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References
Keywords
