1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. TH5427 hydrochloride

TH5427 hydrochloride 

Cat. No.: HY-125209A
Handling Instructions

TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells.

For research use only. We do not sell to patients.

TH5427 hydrochloride Chemical Structure

TH5427 hydrochloride Chemical Structure

CAS No. : 2253744-57-7

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Description

TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells[1].

In Vitro

TH5427 hydrochloride inhibits progestin-dependent nuclear ATP synthesis in breast cancer cells. TH5427 hydrochloride significantly disrupted EGFR and MMTV-luc expression following progestin stimulation. TH5427 hydrochloride abrogates the progestin-dependent proliferation response in T47DWT cells[1].

Molecular Weight

527.79

Formula

C₂₀H₂₁Cl₃N₈O₃

CAS No.

2253744-57-7

SMILES

[H]Cl.O=C(N1C)N(C)C2=C(N(CC3=NN=C(C4=CC=C(Cl)C(Cl)=C4)O3)C(N5CCNCC5)=N2)C1=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TH5427TH 5427TH-5427DNA/RNA SynthesisNUDT5MTH1ATPsynthesischromatinremodelinggeneregulationproliferationbreastcancercellsInhibitorinhibitorinhibit

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TH5427 hydrochloride
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HY-125209A
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