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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
N-Glycosylation
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "N-Glycosylation" in MCE Product Catalog:
Cat. No.: HY-175674
CAS No.: 2763063-40-5
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NGI-235 is an STT3A-selective oligosaccharyltransferase complex OST-A inhibitor. NGI-235 preferentially inhibits OST-A catalytic activity, impairing N-glycosylation of OST-A substrates. NGI-235 causes the hypoglycosylation of both TLR4, GLUT1 and inhibits NF-κB signaling. NGI-235 can be used for the research of inflammation .
Category:
other families Coumarins Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-16304
CAS No.: 27251-84-9
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Human Gut Microbiota Metabolites Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields
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Cat. No.: HY-W010076
CAS No.: 2150-47-2
Methyl 2,4-dihydroxybenzoate is an antifungal agent and plant defense activator. Methyl 2,4-dihydroxybenzoate disrupts the fungal antioxidant system, induces oxidative stress, interferes with N-glycosylation and protein synthesis, inhibits energy metabolism, and impairs transport function. Methyl 2,4-dihydroxybenzoate exhibits potent antifungal activity against the causal agent of banana Panama disease (Fusarium oxysporum f. sp. cubense) . Methyl 2,4-dihydroxybenzoate can also serve as a cosmetic raw material and is used in the synthesis of fine chemical raw materials. Methyl 2,4-dihydroxybenzoate is applicable to research related to Panama disease (Fusarium wilt) .
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Cat. No.: HY-176559
CAS No.: 2823367-88-8
Cat. No.: HY-P991150
CAS No.: 2981477-39-6
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Cat. No.: HY-P4027A
Cat. No.: HY-P4027
CAS No.: 290362-31-1
Cat. No.: HY-E70568
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Protease (O-glycan Cleaving) is recombinantly expressed from E.coli and contains a His tag. Protease (O-glycan Cleaving) is an O-glycan-dependent protease that digests proteins carrying mucin-type O-glycans, including sialylated substrates, glycosylated Ser and Thr residues at the N terminus. Protease (O-glycan Cleaving) digests a variety of O-glycan structures, including sialylated glycosylated core 1 and core 2 structures and Tn antigen. Protease (O-glycan Cleaving) does not digest terminally modified serine or threonine residues, nor does it digest N-glycosylation sites on glycoproteins.
Cat. No.: HY-169003A
CAS No.: 3067185-00-3
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(R,S)-STT3A/B-IN-1 (compound 32), the racemate of STT3A/B-IN-1 (HY-16900), is a STT3A/B inhibitor. (R,S)-STT3A/B-IN-1 inhibits N-Glycosylation. (R,S)-STT3A/B-IN-1 is promising for research of viral diseases, including cancer and neurodegenerative disorders .
Cat. No.: HY-170663
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β-1,4-GALT1-IN-1 (Compound 6) is a β-1,4-GALT1 inhibitor, with an IC50 value of 6.2 μM. β-1,4-GALT1-IN-1 can be used in many pathology investigations such as cancer, autoimmune diseases and viral infections .
Cat. No.: HY-E72111
Human UGT1A9 is a UDP-glucuronosyltransferase. UGT1A9 catalyzes the transfer of glucuronic acid from UDP-glucuronic acid (HY-N7033) to Umbelliferone (HY-N0573), 4-methylumbelliferone (HY-N0187), Scopoletin (HY-N0342), and α-Naphthol. Functional folding of UGT1A9 requires N-glycosylation; the deglycosylated mature protein still retains full activity .
Cat. No.: HY-182914
CAS No.: 2763063-26-7
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NGI‑189 is a selective OST‑A inhibitor. NGI‑189 inhibits the STT3A catalytic subunit of the OST complex and reduces N‑glycosylation of target glycoproteins. NGI‑189 blocks oncogenic and bypass signaling, reduces phosphorylation of EGFR, AKT, p70S6K and S6RP, and induces cell cycle arrest and apoptosis. NGI‑189 markedly suppresses tumor growth and induces tumor regression in non‑small cell lung cancer (NSCLC) xenograft models. NGI‑189 can be used for the research of EGFR‑mutant non‑small cell lung cancer .
Cat. No.: HY-E70069A
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Endo S2 (MS grade) is an IgG-specific endo glycosidase that can hydrolyze the complex N-glycans at the Fc N-glycosylation sites. Endo S2 (MS grade) can hydrolyze the glycosylation modifications following the core GlcNAc of IgG, but its activity is limited for high-mannose type and mixed-type glycans.
Cat. No.: HY-179631
2DG-ODDA is a 2-deoxyglucose (2-DG) (HY-13966) derivative with potent antitumor activity. 2DG-ODDA induces apoptosis, and reduces ATP production. 2DG-ODDA is taken up through both fatty acid and glucose transporters and is cleaved by α-Mannosidase (HY-P2950), releases 2DG to inhibit N-glycosylation and disrupt cellular metabolism. 2DG-ODDA inhibits tumor growth in a 4T1 mouse model. 2DG-ODDA can be used for the research of triple-negative breast cancer (TNBC) .
Cat. No.: HY-182586
CAS No.: 19198-75-5
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Decyl gallate is an antifungal (fungal) agent. Decyl gallate downregulates the expression of the pro-apoptotic (apoptosis) protein Bak, upregulates the expression of the anti-apoptotic protein Bcl-2, and inhibits DNA damage. Decyl gallate disrupts ALG12-mediated N-glycosylation, overactivates the UPR pathway, and simultaneously reduces fungal cell wall enzyme activity, chitin levels, mitochondrial activity, budding ability, cell viability, and host cell adhesion capacity. Decyl gallate reduces inflammatory responses induced by fungal infection and disrupts fungal membrane structure. Decyl gallate can be used in studies related to paracoccidioidomycosis and invasive fungal infections .
Cat. No.: HY-179558
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MS1-96 is an orally active PD-L1 (programmed death-ligand 1) molecular glue degrader. MS1-96 effectively reduced PD-L1 protein levels across multiple colorectal cancer (CRC) cell lines. MS1-96 directly binds to PD-L1 (KD = 2.58 μM) and enhances the interaction between HIP1R and PD-L1, thereby altering the intracellular trafficking of PD-L1 within clathrin-coated vesicles. MS1-96 induces abnormal N-glycosylation of PD-L1, destabilizing the protein and hastening its lysosome-mediated degradation. MS1-96 can be used for the study of colorectal cancer .
Cat. No.: HY-180467A
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Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me (Compound G12) sodium is a disaccharide linker. Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me sodium can be efficiently recognized by the endo-glycosidase Endo-S2 and can be directedly transferred to the conserved N-glycosylation site (Asn297 position) of the antibody's Fc domain through enzymatic catalytic reactions, thereby achieving site-specific modification of the antibody. Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me sodium can be used for for the synthesis of antibody-conjugated drugs (ADCs) .
Cat. No.: HY-180467
CAS No.: 2823367-76-4
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Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me (Compound G12) is a disaccharide linker. Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me can be efficiently recognized by the endo-glycosidase Endo-S2 and can be directedly transferred to the conserved N-glycosylation site (Asn297 position) of the antibody's Fc domain through enzymatic catalytic reactions, thereby achieving site-specific modification of the antibody. Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me can be used for for the synthesis of antibody-conjugated drugs (ADCs) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
