2. Apoptosis
  3. Apoptosis
  4. 2DG-ODDA

2DG-ODDA is a 2-deoxyglucose (2-DG) (HY-13966) derivative with potent antitumor activity. 2DG-ODDA induces apoptosis, and reduces ATP production. 2DG-ODDA is taken up through both fatty acid and glucose transporters and is cleaved by α-Mannosidase (HY-P2950), releases 2DG to inhibit N-glycosylation and disrupt cellular metabolism. 2DG-ODDA inhibits tumor growth in a 4T1 mouse model. 2DG-ODDA can be used for the research of triple-negative breast cancer (TNBC).

For research use only. We do not sell to patients.

2DG-ODDA

2DG-ODDA Chemical Structure

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2DG-ODDA Related Antibodies

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Description

2DG-ODDA is a 2-deoxyglucose (2-DG) (HY-13966) derivative with potent antitumor activity. 2DG-ODDA induces apoptosis, and reduces ATP production. 2DG-ODDA is taken up through both fatty acid and glucose transporters and is cleaved by α-Mannosidase (HY-P2950), releases 2DG to inhibit N-glycosylation and disrupt cellular metabolism. 2DG-ODDA inhibits tumor growth in a 4T1 mouse model. 2DG-ODDA can be used for the research of triple-negative breast cancer (TNBC)[1].

In Vitro

2DG-ODDA (80 μM; 24 h) demonstrates significant reduction in glycolysis-based, mithochondrial and total ATP production in 4T1 TNBC cells, indicating that it disrupts mitochondrial metabolism in addition to glycolysis.[1].
2DG-ODDA (400 μM; 24 h) induces apoptosis in 4T1 TNBC cells[1].
2DG-ODDA (24 h) shows cytotoxicity in 4T1 TNBC cells with an IC50 of ~85 μM, which is a 16-fold improvement over 2DG (IC50 = ~1.34 mM)[1].
2DG-ODDA (85 μM; 24 h) is taken up through both CD36 (fatty acid transporter) and glucose transporters and is cleaved by α-Mannosidase, releasing 2DG to inhibit N-glycosylation and disrupt cellular metabolism[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2DG-ODDA Related Antibodies

Apoptosis Analysis[1]

Cell Line: 4T1 TNBC cells
Concentration: 400 μM
Incubation Time: 24 h
Result: Induced a marked increase in late-apoptotic populations.
In Vivo

2DG-ODDA (7.5 mg/kg; s.c.; three times weekly for 2 weeks) suppresses tumor growth in a 4T1 TNBC mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice subcutaneously inoculated with 4T1 cells[1]
Dosage: 7.5 mg/kg
Administration: s.c.; three times weekly for 2 weeks
Result: Significantly attenuated tumor progression, with final mean tumor volumes ~40% lower than both control groups.
Showed no treatment-related weight loss or clinical signs of adverse events.
Molecular Weight

561.71

Formula

C28H51NO10
SMILES

O=C(N[C@H](CO[C@H]1O[C@H](CO)[C@@H](O)[C@@H](O)C1)C(OC)=O)CCCCCCCCCCCCCCCCC(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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2DG-ODDA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2DG-ODDAApoptosisATP productionfatty acid transportcytotoxic effectsmetabolic vulnerabilitiesserum albuminglucose transportmitochondrial functiondual-transporter uptakeapoptosistumor growth suppressioncancer therapeuticglycolytic inhibitionmetabolic flux analysistriple-negative breast cancerα-mannosidasesInhibitorinhibitorinhibit

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