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NAD(P)H quinone oxidoreductase 1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Quinone Reductase (8) Aminotransferases (Transaminases) (1) Caspase (2) DNA Alkylator/Crosslinker (2) Isotope-Labeled Compounds (1) Keap1-Nrf2 (2) Mitochondrial Metabolism (2) PDHK (2) Reference Standards (2)
By Research Areas:	Cancer (7) Metabolic Disease (3) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Quinone Reductase Endoplasmic Reticulum Oxidoreductase 1 (ERO1) NADPH Oxidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0645

Dicoumarol 10+ Cited Publications Dicumarol	Quinone Reductase PDHK	Cancer
Dicoumarol is an inhibitor of both **NAD(P)H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC₅₀**s of 0.37 and 19.42 μM, respectively.

HY-128895

KL1333 1 Publications Verification	Quinone Reductase Mitochondrial Metabolism	Metabolic Disease
KL1333, a derivative of β-lapachone, is an orally available *NAD+* modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures .

HY-13543

Tretazicar CB 1954	Quinone Reductase DNA Alkylator/Crosslinker	Cancer
Tretazicar (CB 1954), an antitumor proagent, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) .

HY-103667

2-HBA 3 Publications Verification	Quinone Reductase Caspase	Cancer
2-HBA is a potent inducer of **NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10**.

HY-W975966

CPDT	Keap1-Nrf2	Neurological Disease
CPDT is an orally active and highly potent inducer of phase 2 enzymes and an activator of Nrf2. The activities of key phase 2 enzymes, including glutathione S-transferase, NAD(P)H:quinone:oxidoreductase 1 and glutamate cysteine synthetase, and levels of glutathione were elevated by CPDT in rat bladder in vivo and in cultured bladder cells in vitro [2].

HY-169842

NSC 645827	Quinone Reductase	Cancer
NSC 645827 is an inhibitor for **NAD(P)H: quinone oxidoreductase 1 (NQO1) with an IC₅₀** of 0.7 μM .

HY-171035

PRL-295	Quinone Reductase Keap1-Nrf2 Aminotransferases (Transaminases)	Metabolic Disease
PRL-295 is an orally active inhibitor targeting Keap1-Nrf2 interaction. PRL-295 increases the thermal stability of Keap1 and disrupts its interaction with Nrf2, thereby activating the Nrf2-dependent transcriptional target NAD(P)H:quinone oxidoreductase 1 (NQO1). PRL-295 protects against Acetaminophen (HY-66005)-induced liver injury in mice .

HY-N0645S

Dicoumarol-d8 Dicumarol-d₈	Isotope-Labeled Compounds PDHK	Cancer
Dicoumarol-d₈ (Dicumarol-d₈) is the deuterium labeled Dicoumarol. Dicoumarol is an inhibitor of both NAD(P)H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC₅₀s of 0.37 and 19.42 μM, respectively.

HY-13543R

Tretazicar (Standard) CB 1954 (Standard)	DNA Alkylator/Crosslinker Reference Standards	Cancer
Tretazicar (Standard) is the analytical standard of Tretazicar. This product is intended for research and analytical applications. Tretazicar (CB 1954), an antitumor proagent, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) .

HY-128895A

KL1333 hydrochloride	Mitochondrial Metabolism Quinone Reductase	Metabolic Disease
KL1333 hydrochloride is an orally active NAD ⁺ modulator that reacts with **NAD(P)H:quinone oxidoreductase 1 (NQO1*) as a substrate, leading to increased intracellular NAD* ⁺ levels through NADH oxidation. Elevated NAD ⁺ levels trigger activation of SIRT1 and AMPK, and subsequently activate PGC-1α. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) fibroblasts. KL1333 hydrochloride protects against cisplatin-induced ototoxicity in mouse cochlear cultures .

HY-103667R

2-HBA (Standard)	Quinone Reductase Reference Standards Caspase	Cancer
2-HBA (Standard) is the analytical standard of 2-HBA (HY-103667). This product is intended for research and analytical applications. 2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.

Dicoumarol 10+ Cited Publications Dicumarol	Melilotus officinalis (L.) Pall. Classification of Application Fields Leguminosae Coumarins Phenylpropanoids Plants Disease Research Fields Biological Pesticide Research Source Classification Cancer Agricultural Research	Quinone Reductase PDHK
Dicoumarol is an inhibitor of both **NAD(P)H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC₅₀**s of 0.37 and 19.42 μM, respectively.

Dicoumarol-d8
Dicoumarol-d₈ (Dicumarol-d₈) is the deuterium labeled Dicoumarol. Dicoumarol is an inhibitor of both NAD(P)H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC₅₀s of 0.37 and 19.42 μM, respectively.

Host:	Rabbit (2)
Reactivity:	Human (2) Mouse (2) Rat (2)
Application:	IHC-P (2) ICC/IF (1) IP (1) WB (2) ELISA (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810413

	NQO2 Antibody (YA9728) DHQV, DIA6, EC 1.10.99.2, MGC94180, NAD(P)H dehydrogenase quinone 2, NAD(P)H menadione oxidoreductase 1 dioxin inducible 2, NAD(P)H menadione oxidoreductase 2 dioxin inducible, NMOR2, NQO 2, NQO2	WB, IHC-P	Human, Rat, Mouse
	NQO2 Antibody (YA9728) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to NQO2.

HY-P86526

	NQO1 Antibody (YA6218) NQO1; DIA4; NMOR1; NAD; P; H dehydrogenase [quinone] 1; Azoreductase; DT-diaphorase; DTD; Menadione reductase; NAD; P; H:quinone oxidoreductase 1; Phylloquinone reductase; quinone reductase 1; QR1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	NQO1 Antibody (YA6218) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NQO1.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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