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Notoginseng

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By Targets:	Akt (1) Amyloid-β (4) Apoptosis (5) Autophagy (2) Bcl-2 Family (1) Caspase (1) COX (1) Drug Derivative (1) Endogenous Metabolite (3) HIF/HIF Prolyl-Hydroxylase (2) Interleukin Related (1) JNK (2) LXR (1) MMP (1) NF-κB (3) NO Synthase (1) p38 MAPK (1) Reference Standards (3) Src (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (5) Inflammation/Immunology (5) Metabolic Disease (3) Neurological Disease (7)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0044

Ginsenoside Re 4 Publications Verification Ginsenoside B2; Panaxoside Re; Sanchinoside Re	Amyloid-β NF-κB JNK Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Ginsenoside Re (Ginsenoside B2) is an extract from Panax notoginseng. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.

HY-N0615

Notoginsenoside R1 2 Publications Verification Sanchinoside R1; Sanqi glucoside R1	Amyloid-β Apoptosis	Others
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H₂O₂-induced oxidative damage in PC12 cells .

HY-N1477

Dencichine Dencichin; ODAP	HIF/HIF Prolyl-Hydroxylase	Neurological Disease
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.

HY-N0905

Ginsenoside Rh4	Bcl-2 Family Caspase Apoptosis Autophagy Endogenous Metabolite	Cancer
Ginsenoside Rh4 is a rare saponin obtained from Panax notoginseng. Ginsenoside Rh4 activates Bax, caspase 3, caspase 8, and caspase 9. Ginsenoside Rh4 also induces autophagy.

HY-N0046

Notoginsenoside Fe Notoginseng triterpenes; Ginsenoside Mb	Apoptosis Src	Neurological Disease Metabolic Disease Cancer
Notoginsenoside Fe (Notoginseng triterpenes; Ginsenoside Mb) is a saponin with anti-obesity and anti-neuroblastoma activities. Notoginsenoside Fe can be isolated from leaves of Panax notoginseng. Notoginsenoside Fe specifically activates paraventricular nucleus neurons in the hypothalamus, effectively reducing body weight, improving fasting blood glucose and protecting liver function by decreasing food intake, increasing resting metabolic rate and enhancing energy expenditure. Notoginsenoside Fe also inhibits the c-Src signaling pathway, blocks the proliferation and viability of human neuroblastoma cells, while improving mitochondrial dysfunction and alleviating apoptosis. Notoginsenoside Fe can be used in studies related to diet-induced obesity and neuroblastoma .

HY-N0167

Gynostemma Extract 1 Publications Verification Ginsenoside C-Mx1; Gypenoside IX	p38 MAPK Akt NF-κB COX Interleukin Related NO Synthase	Metabolic Disease Inflammation/Immunology
Gynostemma Extract (Gypenoside IX) is a triterpenoid saponin. Gynostemma Extract can be isolated from Panax notoginseng. Gynostemma Extract reduces NFκB nuclear translocation and transcriptional activity by inhibiting the p38 MAPK/Akt/NFκB signaling pathway. Gynostemma Extract reduces the expression of cytokines (COX-2, IL-6) and the production of NO. Gynostemma Extract has anti-inflammatory activity. Gynostemma Extract can be used in the study of liver injury and neuroinflammation .

HY-N2531

Notoginsenoside Fc	Autophagy	Cardiovascular Disease
Notoginsenoside Fc, a protopanaxadiol- (PPD-) type saponin isolated from the leaves of Panax notoginseng, effectively counteracts platelet aggregation. Notoginsenoside Fc can accelerate reendothelialization following vascular injury in diabetic rats by promoting autophagy .

HY-N2503

Ginsenoside F4	Apoptosis MMP	Inflammation/Immunology
Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis . Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues .

HY-N2530

Notoginsenoside Fa	Others	Neurological Disease
Notoginsenoside Fa, a protopanaxadiol (ppd)-type saponin isolated from P. notoginseng, could possibly activate and recover the function of degenerated brain .

HY-N10151

Notoginsenoside R3	Others	Cardiovascular Disease
Notoginsenoside R3 is an active principle components of P. notoginseng. Notoginsenoside R3 act as a signaling molecule that is associated with various physiological effects. P. notoginseng and its components are used as traditional Chinese medicine for cardiovascular disease .

HY-N4305

Notoginsenoside FP2	Others	Cardiovascular Disease
Notoginsenoside FP2, a dammarane-Type Bisdesmoside isolated from the Fruit Pedicels of Panax notoginseng, has potential to treat cardiovascular disease .

HY-N11226

Ginsenoside Ra0	Others	Others
Ginsenoside Ra0 (compound 17) is a dammarane-type saponin that can be isolated from Panax notoginseng .

HY-N5019

Notoginsenoside S	Others	Others
Notoginsenoside S is a compound isolated from Panax notoginseng.

HY-N16751

Notoginsenoside D	Others	Metabolic Disease
Notoginsenoside D is a dammarane-type triterpene oligoglycoside. Notoginsenoside D can be isolated from the dried roots of Panax notoginseng (BURK.) F. H. CHEN. Notoginsenoside D can be used in the research of liver injury .

HY-N16791

Vinaginsenoside R7	Others	Others
Vinaginsenoside R7 is a triterpenoid saponin found in Panax vietnamensis and Panax notoginseng .

HY-N2049

20(R)-Notoginsenoside R2	Others	Neurological Disease
20(R)-Notoginsenoside R2 is an isolated notoginsenoside from Panax notoginseng .

HY-N6030

(Rac)-Dencichine (Rac)-Dencichin; (Rac)-ODAP	HIF/HIF Prolyl-Hydroxylase	Others
(Rac)-Dencichine ((Rac)-Dencichin) is the racemate of Dencichin. Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity .

HY-185104

Ginsenoside C-K hexapropionate ester	LXR	Cardiovascular Disease
Ginsenoside C-K hexapropionate ester (Structure 2) is a selective agonist of LXRα, with no significant activation effect on LXRβ. Ginsenoside C-K hexapropionate ester upregulates the expression of downstream genes such as ABCA1 by activating LXRα, promoting reverse cholesterol transport, and reducing lipid deposition in macrophage-derived foam cells. It can be used in the research of atherosclerosis. Ginsenoside C-K hexapropionate ester is a derivative synthesized from ginsenoside Compound K, an active metabolite of Panax notoginseng saponins, by modification with propionic anhydride .

HY-N6581

Notoginsenoside T5	Others	Cardiovascular Disease Cancer
Notoginsenoside T5 is a dammarane 61 glycoside. Notoginsenoside T5 is isolated from the acidic deglycosylation of saponins from the roots of P. 62 notoginseng .

HY-N2530R

Notoginsenoside Fa (Standard)	Reference Standards Others	Neurological Disease
Notoginsenoside Fa (Standard) is the analytical standard of Notoginsenoside Fa. This product is intended for research and analytical applications. Notoginsenoside Fa, a protopanaxadiol (ppd)-type saponin isolated from P. notoginseng, could possibly activate and recover the function of degenerated brain .

HY-N0044R

Ginsenoside Re (Standard) Ginsenoside B2(Standard); Panaxoside Re(Standard); Sanchinoside Re (Standard)	Reference Standards Amyloid-β NF-κB JNK Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Ginsenoside Re (Standard) is the analytical standard of Ginsenoside Re. This product is intended for research and analytical applications. Ginsenoside Re (Ginsenoside B2) is an extract from Panax notoginseng. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.

HY-N18670

*Panax notoginseng* extract**	Others	Others
Panax notoginseng extract is derived from the stems and leaves of Panax notoginseng, a plant belonging to the Araliaceae family. Its main active ingredient is notoginsenoside (PNS), among which notoginsenoside Rb1, notoginsenoside Rg1, and notoginsenoside R1 are present in high amounts and can be used for skin conditioning in functional cosmetics.

HY-N0615R

Notoginsenoside R1 (Standard) Sanchinoside R1 (Standard); Sanqi glucoside R1 (Standard)	Reference Standards Amyloid-β Apoptosis	Others
Notoginsenoside R1 (Standard) is the analytical standard of Notoginsenoside R1. This product is intended for research and analytical applications. Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells .

HY-N17972

Floranotoginsenoside D	Others	Others
Floranotoginsenoside D (Compound 4) is a dammarane-type triterpene saponin found in the flowers of Panax notoginseng .

HY-N18382

5,6-Didehydroginsenoside Rb1	Others	Others
5,6-Didehydroginsenoside Rb1 is a dammarane-type saponin. 5,6-Didehydroginsenoside Rb1 can be isolated from the dried roots of Panax notoginseng .

HY-N4263

5,6-Didehydroginsenoside Rd	Others	Inflammation/Immunology
5,6-Didehydroginsenoside Rd is a dammarane-type saponin isolated from the dried roots of Panax notoginseng .

HY-N17404

Pseudoginsenoside-RT3	Drug Derivative	Others
Pseudoginsenoside-RT3 is a natural product that can be found in Panax notoginseng?(Burkill) F. H. Chen ex C. H. Chow.

HY-N1569

Pteroside D (3S)-Pteroside D	Others	Others
Pteroside D ((3S)-Pteroside D) is a Alkaloids product that can be isolated from the roots of Panax notoginseng (Burk.)F.H.Chen .

Cat. No.	Product Name	Target	Research Area

HY-P1936

Cyclo(Gly-L-Pro)	Peptides	Others
Cyclo(Gly-L-Pro) is a Alkaloids product that can be isolated from the roots of Panax notoginseng (Burk.)F.H.Chen .

HY-P5751

Cyclo(Ile-Val)	Peptides	Others
Cyclo(Ile-Val) is a Alkaloids product that can be isolated from the roots of Panax notoginseng (Burk.)F.H.Chen .

Ginsenoside Re 4 Publications Verification Ginsenoside B2; Panaxoside Re; Sanchinoside Re	Panax ginseng C. A. Meyer Triterpenes Neurological Disease Classification of Application Fields Terpenoids Plants Endogenous metabolite Disease Research Fields Araliaceae Source Classification Cancer	Amyloid-β NF-κB JNK Endogenous Metabolite
Ginsenoside Re (Ginsenoside B2) is an extract from Panax notoginseng. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.

Notoginsenoside R1 2 Publications Verification Sanchinoside R1; Sanqi glucoside R1	Triterpenes Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Araliaceae Source Classification	Amyloid-β Apoptosis
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H₂O₂-induced oxidative damage in PC12 cells .

Dencichine Dencichin; ODAP	Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Amino acids Plants Araliaceae Source Classification	HIF/HIF Prolyl-Hydroxylase
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.

Ginsenoside Rh4	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification Cancer	Bcl-2 Family Caspase Apoptosis Autophagy Endogenous Metabolite
Ginsenoside Rh4 is a rare saponin obtained from Panax notoginseng. Ginsenoside Rh4 activates Bax, caspase 3, caspase 8, and caspase 9. Ginsenoside Rh4 also induces autophagy.

Notoginsenoside Fe Notoginseng triterpenes; Ginsenoside Mb	Triterpenes Structural Classification Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Araliaceae Source Classification	Apoptosis Src
Notoginsenoside Fe (Notoginseng triterpenes; Ginsenoside Mb) is a saponin with anti-obesity and anti-neuroblastoma activities. Notoginsenoside Fe can be isolated from leaves of Panax notoginseng. Notoginsenoside Fe specifically activates paraventricular nucleus neurons in the hypothalamus, effectively reducing body weight, improving fasting blood glucose and protecting liver function by decreasing food intake, increasing resting metabolic rate and enhancing energy expenditure. Notoginsenoside Fe also inhibits the c-Src signaling pathway, blocks the proliferation and viability of human neuroblastoma cells, while improving mitochondrial dysfunction and alleviating apoptosis. Notoginsenoside Fe can be used in studies related to diet-induced obesity and neuroblastoma .

Gynostemma Extract 1 Publications Verification Ginsenoside C-Mx1; Gypenoside IX	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Plants Endogenous metabolite Gynostemma pentaphyllum (Thunb.) Makino Disease Research Fields Source Classification Cancer	p38 MAPK Akt NF-κB COX Interleukin Related NO Synthase
Gynostemma Extract (Gypenoside IX) is a triterpenoid saponin. Gynostemma Extract can be isolated from Panax notoginseng. Gynostemma Extract reduces NFκB nuclear translocation and transcriptional activity by inhibiting the p38 MAPK/Akt/NFκB signaling pathway. Gynostemma Extract reduces the expression of cytokines (COX-2, IL-6) and the production of NO. Gynostemma Extract has anti-inflammatory activity. Gynostemma Extract can be used in the study of liver injury and neuroinflammation .

Cyclo(Gly-L-Pro)	Alkaloids Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Plants Araliaceae Source Classification	Others
Cyclo(Gly-L-Pro) is a Alkaloids product that can be isolated from the roots of Panax notoginseng (Burk.)F.H.Chen .

Notoginsenoside Fc	Cardiovascular Disease Triterpenes Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification	Autophagy
Notoginsenoside Fc, a protopanaxadiol- (PPD-) type saponin isolated from the leaves of Panax notoginseng, effectively counteracts platelet aggregation. Notoginsenoside Fc can accelerate reendothelialization following vascular injury in diabetic rats by promoting autophagy .

Ginsenoside F4	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	Apoptosis MMP
Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis . Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues .

Notoginsenoside Fa	Triterpenes Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Terpenoids Plants Araliaceae Source Classification	Others
Notoginsenoside Fa, a protopanaxadiol (ppd)-type saponin isolated from P. notoginseng, could possibly activate and recover the function of degenerated brain .

Notoginsenoside R3	Cardiovascular Disease Triterpenes Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification	Others
Notoginsenoside R3 is an active principle components of P. notoginseng. Notoginsenoside R3 act as a signaling molecule that is associated with various physiological effects. P. notoginseng and its components are used as traditional Chinese medicine for cardiovascular disease .

Notoginsenoside FP2	Cardiovascular Disease Triterpenes Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification	Others
Notoginsenoside FP2, a dammarane-Type Bisdesmoside isolated from the Fruit Pedicels of Panax notoginseng, has potential to treat cardiovascular disease .

Ginsenoside Ra0	Triterpenes Structural Classification Tetracyclic Triterpenoids Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Terpenoids Plants Araliaceae Source Classification	Others
Ginsenoside Ra0 (compound 17) is a dammarane-type saponin that can be isolated from Panax notoginseng .

Notoginsenoside S	Triterpenes Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Araliaceae Source Classification	Others
Notoginsenoside S is a compound isolated from Panax notoginseng.

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Notoginseng

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