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OGT+inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (6) OGT (10)
By Research Areas:	Cancer (1) Metabolic Disease (7)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119738

OSMI-1 Maximum Cited Publications 42 Publications Verification	OGT Acyltransferase	Metabolic Disease
OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC₅₀ value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .

HY-114361

OSMI-4 25+ Cited Publications	OGT Acyltransferase	Metabolic Disease
OSMI-4 is a low nanomolar O-GlcNAc transferase *(OGT)* inhibitor, with an EC₅₀ of 3 μM in cells.

HY-136282

ST045849 OGT-IN-2	Acyltransferase OGT	Metabolic Disease
ST045849 (OGT-IN-2) is a small-molecule *OGT* inhibitor with an IC₅₀ of 30 μM against sOGT and 53 μM against ncOGT. ST045849 is applicable to research on metabolism-related diseases .

HY-148113

PG 34	OGT	Others
PG 34 is a weak O-GlcNAc transferase (OGT) inhibitor (IC₅₀=68 μM), and a close structural analog of OSMI-1 (HY-119738) .

HY-135784

OSMI-2 1 Publications Verification	OGT Acyltransferase	Metabolic Disease
OSMI-2 (Compound 1b) is a cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-2 increases detained intron splicing in cells .

HY-101548

OGT-IN-1	OGT	Metabolic Disease
OGT-IN-1 (Compound 5) is a potent *OGT* inhibitor. OGT-IN-1 inhibits sOGT and ncOGT with IC₅₀s of 27 and 10 μM, respectively .

HY-149552

Ac4-5SGlcNAc	OGT	Cancer
Ac4-5SGlcNAc is an O-GlcNAc transferase (OGT) inhibitor. Ac4-5SGlcNAc converts intracellularly to UDP-5SGlcNAc, which competes with native UDP-GlcNAc (HY-148596) to block OGT catalytic activity, reduces cellular UDP-GlcNAc pools, and limits global protein O-GlcNAcylation. Ac4-5SGlcNAc reduces OGA levels via feedback, alters lectin signal intensities and glycan-related band masses. Ac4-5SGlcNAc can be used for the research of breast cancer .

HY-125278

OGT-IN-4	OGT	Others
OGT-IN-4 (compound 4a) is an O-GlcNAc transferase (OGT) inhibitor with a K_d of 8 nM. OGT-IN-4 can be utilized in OGT related research .

HY-119738A

(Rac)-OSMI-1	OGT Acyltransferase	Metabolic Disease
(Rac)-OSMI-1 is the racemate of OSMI-1. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC₅₀ value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .

HY-135785

OSMI-3	OGT Acyltransferase	Metabolic Disease
OSMI-3 (Compound 2b) is a potent, long-lasting, and cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-3 increases detained intron splicing in cells .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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OGT+inhibitor

Inhibitors & Agonists