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PSY

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By Targets:	Biochemical Assay Reagents (2) Drug Derivative (2) Endogenous Metabolite (3) Factor Xa (2) Phospholipase (1) PKC (3) Reference Standards (1)
By Research Areas:	Cancer (4) Metabolic Disease (2) Neurological Disease (4)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136490

Psychosine Galactosylsphingosine	PKC	Neurological Disease Cancer
Psychosine (Galactosylsphingosine), a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease . Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell types including, most relevantly to globoid cell leukodystrophy (GLD), oligodendrocytes. Psychosine causes cell death at least in part via apoptosis. Psychosine also is an inhibitor of PKC .

HY-136490S

Psychosine-d5 Galactosylsphingosine-d₅	PKC	Neurological Disease Cancer
Psychosine-d₅ is deuterium labeled Psychosine. Psychosine, a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell.

HY-113236

p-Synephrine 2 Publications Verification	Endogenous Metabolite	Others
p-Synephrine is an organic compound, found in multiple biofluids, such as urine and blood.

HY-136490S1

Psychosine-d7 Galactosylsphingosine-d₇	PKC	Neurological Disease Cancer
Psychosine-d₇ is deuterium labeled Psychosine. Psychosine, a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell

HY-142975

N-Pentadecanoyl-psychosine C15 Galactosylceramide (d18:1/15:0); GalCer(d18:1/15:0)	Endogenous Metabolite	Others
N-Pentadecanoyl-psychosine is a glycolipid that can be used in membrane adhesion studies .

HY-166257

Lyso-sulfatide (bovine) PSYchosine 3′-O-sulfate; PSYchosine 3′-sulfate	Biochemical Assay Reagents Factor Xa	Metabolic Disease
Lyso-sulfatide (bovine) is a phospholipid component derived from sphingolipid catabolism and a potent factor Xa inhibitor and anticoagulant. Lyso-sulfatide (bovine) binds directly to factor Xa and inhibits prothrombin activation mediated by the prothrombinase complex, thereby prolonging factor Xa-induced plasma clotting time and suppressing thrombin generation. Lyso-sulfatide (bovine) serves as a reliable lipid membrane mimic for studying cell membrane structure, function, and molecular interactions .

HY-113236R

p-Synephrine (Standard)	Endogenous Metabolite Reference Standards	Others
p-Synephrine (Standard) is the analytical standard of p-Synephrine. This product is intended for research and analytical applications. p-Synephrine is an organic compound, found in multiple biofluids, such as urine and blood.

HY-N12398

Psychotridine	Others	Neurological Disease
Psychotridine is a natural alkaloid isolated from Psychotria colorata, reveals an analgesic activity in nervous system and an inhibitory efficacy towards platelet aggregation .

HY-158736

Lyso-sulfatide (bovine) ammonium PSYchosine 3′-O-sulfate ammonium; PSYchosine 3′-sulfate ammonium	Phospholipase	Cancer
Lyso-sulfatide (bovine) ammonium, a derivative of the glycosphingolipid sulfatide, acts as an extracellular signal regulating the migration of a neural precursor cell line (B35 neuroblastoma cells) by rapidly promoting process retraction and cell rounding .

HY-N19280

Psychotrine	Others	Others
Psychotrine is an ipecac alkaloid found in the dried roots of Cephaelis acuminata .

HY-164158

N,N-Dimethyl psychosine	Drug Derivative	Others
N,N-Dimethyl psychosine is a derivative of Psychosine (HY-136490). N,N-Dimethyl psychosine can be used as an internal standard compound to quantify Psychosine in alkaline-treated lipid extracts .

HY-165180

Lyso-sulfatide (bovine) sodium PSYchosine 3′-O-sulfate sodium; PSYchosine 3′-sulfate sodium	Biochemical Assay Reagents Factor Xa	Metabolic Disease
Lyso-sulfatide (bovine) sodium is a phospholipid component derived from sphingolipid catabolism and a potent factor Xa inhibitor and anticoagulant. Lyso-sulfatide (bovine) sodium binds directly to factor Xa and inhibits prothrombin activation mediated by the prothrombinase complex, thereby prolonging factor Xa-induced plasma clotting time and suppressing thrombin generation. Lyso-sulfatide (bovine) sodium serves as a reliable lipid membrane mimic for studying cell membrane structure, function, and molecular interactions .

HY-175138

N-Glycine galactosylsphingosine (d18:1) N-Glycine PSYchosine	Drug Derivative	Others
N-Glycine galactosylsphingosine (d18:1) (N-Glycine psychosine) is a glycinated form of galactosylsphingosine (HY-136490) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113236

p-Synephrine 2 Publications Verification	Alkaloids Citrus × aurantium Linnaeus Monophenols Classification of Application Fields Other Diseases Rutaceae Phenols Plants Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
p-Synephrine is an organic compound, found in multiple biofluids, such as urine and blood.

HY-113236R

p-Synephrine (Standard)	Alkaloids Structural Classification Citrus × aurantium Linnaeus Monophenols Other Alkaloids Rutaceae Phenols Plants Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
p-Synephrine (Standard) is the analytical standard of p-Synephrine. This product is intended for research and analytical applications. p-Synephrine is an organic compound, found in multiple biofluids, such as urine and blood.

HY-N12398

Psychotridine	Alkaloids Psychotria forsteriana A.Gray Rubiaceae Plants Indole Alkaloids Source Classification	Others
Psychotridine is a natural alkaloid isolated from Psychotria colorata, reveals an analgesic activity in nervous system and an inhibitory efficacy towards platelet aggregation .

HY-N19280

Psychotrine	Structural Classification Alkaloids Carapichea ipecacuanha (Brot.) L.Andersson Rubiaceae Plants Isoquinoline Alkaloids Source Classification	Others
Psychotrine is an ipecac alkaloid found in the dried roots of Cephaelis acuminata .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702308

	GPR65 Protein, Human (Cell-Free, His) PSYchosine receptor; G-protein coupled receptor 65; T-cell death-associated gene 8 protein	Human	E. coli Cell-free
	GPR65 Protein, a receptor for psychosine (PSY) and related glycosphingolipids, is vital in immune responses. It preserves lysosome function, aiding phagocytosis for intracellular bacteria clearance. GPR65's involvement in activation-induced cell death or T-cell differentiation suggests its potential regulatory role in immune processes. GPR65 Protein, Human (Cell-Free, His) is the recombinant human-derived GPR65 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-136490S

Psychosine-d5
Psychosine-d₅ is deuterium labeled Psychosine. Psychosine, a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell.

HY-136490S1

Psychosine-d7
Psychosine-d₇ is deuterium labeled Psychosine. Psychosine, a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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PSY

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