Search Result

Results for "

Persisters

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Asialoglycoprotein Receptor (ASGPR) (1) Autophagy (1) Bacterial (6) Biochemical Assay Reagents (2) Calcium Channel (1) CaMK (1) Cholinesterase (ChE) (1) Drug-Linker Conjugates for ADC (1) Endogenous Metabolite (2) Environmental Pollutants (2) Fungal (1) Histone Demethylase (3) Opioid Receptor (1) Parasite (1) Reference Standards (1) Small Interfering RNA (siRNA) (1) Virus Protease (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (4) Infection (6) Neurological Disease (2)
Oligonucleotides:	siRNA drugs (1) siRNAs (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100421

CPI-455 Maximum Cited Publications 13 Publications Verification	Histone Demethylase	Cancer
CPI-455 is a specific, pan-KDM5 inhibitor with an IC₅₀ of 10 nM for KDM5A. CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents .

HY-100576

NH125 2 Publications Verification	CaMK Autophagy Bacterial Fungal Virus Protease	Infection Cancer
NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII) with an IC₅₀ of 60 nM for eEF-2K. NH125 kills methicillin-resistant S. aureus (MRSA) persisters by interacting with and disrupting membranes .

HY-B1027

4-Nonylphenol polyethoxylate Nonoxynol; Nonoxinol	Environmental Pollutants Biochemical Assay Reagents	Others
4-Nonylphenol polyethoxylate (Nonoxynol) is a non-ionic surfactant. 4-Nonylphenol polyethoxylate forms degradation products including 4-nonylphenol and short ethoxyl chain polyethoxylates. 4-Nonylphenol polyethoxylate generates degradation products that exhibit estrogenic activity, persist in aquatic environments, and bioaccumulate in the food chain .

HY-100421A

CPI-455 hydrochloride Maximum Cited Publications 13 Publications Verification	Histone Demethylase	Cancer
CPI-455 hydrochloride is a specific, pan-KDM5 inhibitor with an IC₅₀ of 10 nM for KDM5A. CPI-455 hydrochloride mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents .

HY-E70541B

Canine Factor IX	Biochemical Assay Reagents	Cardiovascular Disease
Canine Factor IX is a functional coagulation factor. Canine Factor IX shortens whole blood clotting time and activated partial thromboplastin time, and restores coagulation function. After intramuscular administration via rAAV vector in hemophilia B dogs, Canine Factor IX maintains a sustained circulating level for at least 1 year, partially corrects the hemophilia B phenotype in a dose-dependent manner, and its plasma expression persists for more than 17 months. Canine Factor IX is applicable to relevant research on hemophilia B .

HY-Y1718

Tridecanoic acid 1 Publications Verification N-Tridecanoic acid	Endogenous Metabolite Bacterial	Infection
Tridecanoic acid (N-Tridecanoic acid) is a medium-chain saturated fatty acid and inhibitor with no antibacterial activity against enterohemorrhagic E. coli (EHEC). When used in combination with Ciprofloxacin (HY-B0356) or Ampicillin (HY-B0522), Tridecanoic acid suppresses persister formation in exponentially growing E. coli and EHEC, but exerts no inhibitory effect on persister formation induced by Kanamycin (HY-16566) or in stationary-phase cells. Tridecanoic acid inhibits biofilm formation in EHEC. It can be used in the research of bacterial infections .

HY-N16470

Echiumine	Endogenous Metabolite	Others
Echiumine, a pyrrolizidine alkaloid, is a major dehydropyrrolizidine metabolite of Echium plantagineum. Echiumine has significant hepatotoxic activity and can persist intact from honey through to the resulting mead .

HY-146047

Antibacterial agent 94	Bacterial	Infection
Antibacterial agent 94 (compound 5b) is a potent antibacterial agent. Antibacterial agent 94 show antibacterial activities and show the capability of eradicating MRSA persisters. Antibacterial agent 94 has an effect on bacterial membrane. Antibacterial agent 94 interferes in phosphatidylglycerol (PG) synthesis pathway .

HY-128905

MC-Val-Cit-PAB-dimethylDNA31	Drug-Linker Conjugates for ADC	Cancer
MC-Val-Cit-PAB-dimethylDNA31 is a agent-linker conjugate for ADC with potent antitumor activity by using dimethylDNA31, linked via the ADC linker MC-Val-Cit-PAB. DimethylDNA31 has effective bactericidal activity against persisters and stationary-phase S. aureus.

HY-P11106

cCF10	Bacterial	Infection
cCF10 is a peptide sex pheromone. cCF10 induces transfer of the conjugative plasmid pCF10 from plasmid-containing donor cells to plasmid-free recipient cells. cCF10 induces Opp system and enters bacterial cells to inhibit (p)ppGpp accumulation. cCF10 reduces persister cell generation via maintaining the metabolically active state of bacteria .

HY-126336

HM12	Calcium Channel	Cardiovascular Disease Neurological Disease
HM12 is a covalent inhibitor of L-/T-type calcium channels. HM12 can strongly inhibit the Cav1.2 (L-type) and Cav3.2 (T-type) calcium channels, and has selectivity for the N-type channels. HM12 produces an irreversible inhibition that persisted after washout. HM12 can be used to study diseases such as hypertension, pain, epilepsy, etc .

HY-145649A

Zilebesiran sodium AD-85481 sodium; ALN-AGT sodium	Small Interfering RNA (siRNA) Asialoglycoprotein Receptor (ASGPR)	Cardiovascular Disease
Zilebesiran (AD-85481; ALN-AGT) sodium is a long-acting liver-targeted small interfering RNA (siRNA) antihypertensive agent. Zilebesiran sodium binds to the hepatic asialoglycoprotein receptor (ASGPR), activates the RNA-induced silencing complex to degrade hepatic angiotensinogen mRNA, thereby inhibiting the gene expression and synthesis of angiotensinogen. Zilebesiran sodium dose-dependently reduces serum angiotensinogen levels and 24-hour ambulatory blood pressure, with its effect persisting throughout the circadian cycle. Zilebesiran sodium is applicable to research related to hypertension .

HY-B0273B

Sulfadiazine 100 µg/mL in methanol 5+ Cited Publications	Parasite Bacterial Environmental Pollutants	Infection
Sulfadiazine 100 µg/mL in methanol is an orally active sulfonamide antibiotic. Sulfadiazine 100 µg/mL in methanol competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine 100 µg/mL in methanol persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine 100 µg/mL in methanol targets Toxoplasma gondii DHPS enzyme. Sulfadiazine 100 µg/mL in methanol can be used for the research of congenital toxoplasmosis and bacterial infection .

HY-135698

Methocinnamox M-CAM	Opioid Receptor	Neurological Disease
Methocinnamox (M-CAM) a selective and long-acting μ-opioid receptor (MOR) antagonist with a K_i of 0.6 nM. Methocinnamox binds to the orthosteric site of the MOR in a pseudo-irreversible, non-covalent manner, resulting in prolonged receptor blockade that persists until new receptors are synthesized. Methocinnamox acts as a reversible antagonist at both the kappa-opioid receptor (KOR) (K_i = 4.9 nM) and delta-opioid receptor (DOR) (K_i = 2.2 nM), and it exhibits no intrinsic agonist activity at these receptors. Methocinnamox can be used to reverse and prevent opioid overdose and addiction .

HY-161258

Antibacterial agent 181	Bacterial	Infection
Antibacterial agent 181 (Compound 3f) is a potent ciprofloxacin cationic antibacterial agent with low cytotoxicity. The MIC values of Antibacterial agent 181 against Staphylococcus aureus and Escherichia coli are both 2 μg/mL .

HY-16183A

Echothiopate chloride Echothiophate chloride	Cholinesterase (ChE)	Cardiovascular Disease
Echothiophate (Echothiophate) chloride is a highly effective, long-lasting cholinesterase inhibitor employed as a miotic for managing glaucoma. Echothiopate chloride forms a covalent bond with the serine residue at the active site of cholinesterase through its phosphate group, rendering the enzyme permanently inactive and necessitating the synthesis of new enzymes by the cell. Given its irreversible binding to cholinesterase and the extremely slow rate of hydrolysis, the effects of echothiophate can persist for a week or longer. Echothiopate chloride is utilized as an ocular antihypertensive agent in the treatment of chronic glaucoma and, in certain cases, accommodative esotropia.

HY-100421R

CPI-455 (Standard)	Histone Demethylase Reference Standards	Cancer
CPI-455 (Standard) is the analytical standard of CPI-455 (HY-100421). This product is intended for research and analytical applications. CPI-455 is a specific, pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A. CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents .

Cat. No.	Product Name

HY-L003

Apoptosis Compound Library	3,407 compounds
Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions, which is also called programmed cell death (PCD). Apoptosis plays a crucial role in developing and maintaining the health of the body by eliminating old cells, unhealthy cells and unnecessary cells. Too little or too much apoptosis contribute to many diseases. When apoptosis does not work correctly, cells that should be eliminated may persist and become immortal, for example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer's, Huntington's, and Parkinson's disease. MCE designs a unique collection of 3,407 apoptosis-related compounds mainly focusing on the key targets in the apoptosis signaling pathway and can be used in the research of apoptosis signal pathway and related diseases.

Apoptosis Compound Library

3,407 compounds

Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions, which is also called programmed cell death (PCD). Apoptosis plays a crucial role in developing and maintaining the health of the body by eliminating old cells, unhealthy cells and unnecessary cells. Too little or too much apoptosis contribute to many diseases. When apoptosis does not work correctly, cells that should be eliminated may persist and become immortal, for example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer's, Huntington's, and Parkinson's disease.

MCE designs a unique collection of 3,407 apoptosis-related compounds mainly focusing on the key targets in the apoptosis signaling pathway and can be used in the research of apoptosis signal pathway and related diseases.

Cat. No.	Product Name	Target	Research Area