MC-Val-Cit-PAB-dimethylDNA31

製品番号: HY-128905 純度: 99.58%: Data Sheet SDS COA 取扱説明書
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MC-Val-Cit-PAB-dimethylDNA31 is a agent-linker conjugate for ADC with potent antitumor activity by using dimethylDNA31, linked via the ADC linker MC-Val-Cit-PAB. DimethylDNA31 has effective bactericidal activity against persisters and stationary-phase S. aureus.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

MC-Val-Cit-PAB-dimethylDNA31 構造式

CAS 番号 : 1639352-06-9

容量	価格（税別）	在庫状況	数量
1 mg	$480	在庫あり	Estimated Time of Arrival: December 31
5 mg	$1200	在庫あり	Estimated Time of Arrival: December 31
10 mg	$1900	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Drug-Linker Conjugates for ADC アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

Traditional Cytotoxic Agents

分子量

1518.15

分子式

C₇₈H₁₀₁ClN₁₀O₁₉

CAS 番号

1639352-06-9

Appearance

Solid

Color

Light blue to blue

SMILES

O=C(C=CC1=O)N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C2)=CC=C2C[N+](C)(C)C(CC3)CCN3C4=CC(OC(C5=N6)=C(NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@@H]([C@H](C)[C@@H](OC)/C=C/O7)OC(C)=O)=O)C(C8=C5C9=C(O[C@@]7(C)C9=O)C(C)=C8O)=O)=C6C(O)=C4)=O)=O)=O.[Cl-]

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶剤 & 溶解度

体外:

DMSO : 25 mg/mL (16.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6587 mL	3.2935 mL	6.5870 mL
5 mM	0.1317 mL	0.6587 mL	1.3174 mL
10 mM	0.0659 mL	0.3293 mL	0.6587 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.97%

Select Batch:

データシート (271 KB) SDS (252 KB)

COA (251 KB) HNMR (512 KB) RP-HPLC (192 KB) LCMS (96 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.6587 mL	3.2935 mL	6.5870 mL	16.4674 mL
	5 mM	0.1317 mL	0.6587 mL	1.3174 mL	3.2935 mL
	10 mM	0.0659 mL	0.3293 mL	0.6587 mL	1.6467 mL
	15 mM	0.0439 mL	0.2196 mL	0.4391 mL	1.0978 mL