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  4. Canine Factor IX

Canine Factor IX is a functional coagulation factor. Canine Factor IX shortens whole blood clotting time and activated partial thromboplastin time, and restores coagulation function. After intramuscular administration via rAAV vector in hemophilia B dogs, Canine Factor IX maintains a sustained circulating level for at least 1 year, partially corrects the hemophilia B phenotype in a dose-dependent manner, and its plasma expression persists for more than 17 months. Canine Factor IX is applicable to relevant research on hemophilia B.

For research use only. We do not sell to patients.

Canine Factor IX

Canine Factor IX Chemical Structure

CAS No. : 9001-28-9

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100 μg In-stock

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Canine Factor IX Related Antibodies

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Description

Canine Factor IX is a functional coagulation factor. Canine Factor IX shortens whole blood clotting time and activated partial thromboplastin time, and restores coagulation function. After intramuscular administration via rAAV vector in hemophilia B dogs, Canine Factor IX maintains a sustained circulating level for at least 1 year, partially corrects the hemophilia B phenotype in a dose-dependent manner, and its plasma expression persists for more than 17 months. Canine Factor IX is applicable to relevant research on hemophilia B[1][2].

In Vitro

Canine Factor IX (104-105 vector particles/cell; 36 h post-transduction) was secreted in biologically active form following transduction of HEK-293 cells with AAV-CMV-cF.IX vector, measurable via ELISA of cell supernatants[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Canine Factor IX Related Antibodies

ELISA Assay[2]

Cell Line: HEK-293 cells
Concentration: 104, 105 vector particles/cell
Incubation Time: 36 h post-transduction
Result: Resulted in detectable secretion of biologically active canine Factor IX into cell supernatants.
In Vivo

Canine Factor IX (1.3 × 1011-8.5 × 1012 vector particles/kg; intramuscular injection; single administration) enables dose-dependent, stable long-term expression of biologically active canine F.IX[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Outbred dogs (male and female; 2, 4, 8 months old; 5.7-20 kg; spontaneous severe hemophilia B with undetectable endogenous F.IX)[2]
Dosage: 1.3 × 1011; 1.1 × 1012; 3.4 × 1012; 3 × 1012; 8.5 × 1012 vector particles/kg
Administration: i.m.; single dose
Result: Was stably expressed in plasma in a dose-dependent manner, reaching up to 69 ng/ml, WBCT and APTT were persistently shortened, immune responses against cFIX were absent or transient, and no local or systemic toxicity was observed.
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Canine Factor IX]
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Canine Factor IX Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Canine Factor IX9001-28-9Biochemical Assay Reagentsprimary canine fibroblast cellshemophilia B caninesrAAV vectorblood coagulation factormammalian cellsHeLa cellsHEK-293 cellsmuscle cellsFIX-deficient plasmaInhibitorinhibitorinhibit

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