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Receptor-interacting protein kinase 1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	RIP kinase (11) Necroptosis (2)
By Research Areas:	Cancer (3) Infection (1) Inflammation/Immunology (8) Neurological Disease (4)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Targets Recommended: RIP kinase

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-114371

Eclitasertib DNL-758; SAR-443122	RIP kinase	Inflammation/Immunology
Eclitasertib (DNL-758) is a potent receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC₅₀ of 0.0375 µΜ .

HY-114492

GSK547 GSK'547	RIP kinase	Cancer
GSK547 (GSK'547) is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIPK1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer .

HY-148297

Ocadusertib LY3871801; R 552	RIP kinase	Inflammation/Immunology
Ocadusertib is a potent *Serine/Threonine kinase* receptor-interacting protein kinase 1 (RIPK1)** inhibitor .

HY-18901

RIPK1-IN-4	RIP kinase	Inflammation/Immunology
RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC₅₀s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase .

HY-148382

RI-962	RIP kinase Necroptosis	Neurological Disease Inflammation/Immunology
RI-962 is a potent and selective receptor-interacting protein kinase 1 (RIPK1) inhibitor. RI-962 inhibits RIPK1 with an IC₅₀ value of 35.0 nM. RI-962 can be used for the research of nervous system diseases and inflammatory diseases .

HY-162880

RIPK1-IN-24	RIP kinase	Inflammation/Immunology
RIPK1-IN-24 is a receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC₅₀ value of 1.3 μM. RIPK1-IN-24 can be used for research on inflammatory diseases .

HY-114492A

(Rac)-GSK547	RIP kinase	Cancer
(Rac)-GSK547 is the racemate of GSK547. GSK547 is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer .

HY-173574

RIPK1-IN-31	RIP kinase	Infection Neurological Disease Inflammation/Immunology
RIPK1-IN-31 (Compound 36) is a selective allosteric modulator of RIPK1 (receptor-interacting protein kinase 1) with an IC₅₀ value of 16 nM. RIPK1-IN-31 is promising for research of infectious, autoimmune, and neurodegenerative diseases .

HY-162237

RIPK1-IN-22	RIP kinase	Inflammation/Immunology
RIPK1-IN-13 (compound 28) is a selective inhibitor for receptor-interacting serine/threonine-protein kinase 1 (RIPK1), the inhibitory activity is measured by ADP-Glo Kinase Assay with a pK_i of 7.66. RIPK1-IN-13 inhibits human leukaemia cells U937 with a pIC₅₀ of 7.2 .

HY-161911

Necroptosis-IN-5	Necroptosis RIP kinase	Neurological Disease Inflammation/Immunology Cancer
Necroptosis-IN-5 (Compound 26) is an orally active necroptosis inhibitor. Necroptosis-IN-5 also exhibits potent inhibitory activity against receptor-interacting protein kinase 1 (RIPK1). Necroptosis-IN-5 can be used to study necroptosis-related inflammatory diseases, neurodegenerative diseases, and cancers .

HY-162928

RIPK1-IN-26	RIP kinase	Neurological Disease
RIPK1-IN-26 (Compound 8a) is a potent receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitor with cell anti-necroptosis potency. RIPK1-IN-26 demonstrats good metabolic stability and good binding specificity in mice. RIPK1-IN-26 is promising for research of PET imaging probe development and neurodegenerative disorders .

Species:	Human (1) Rat (1) Mouse (1) Cynomolgus (2) Dog (1)
Tag:	His (2) GST (5)
Source:	Sf9 insect cells (5) E. coli (1)

Cat. No.	Compare	Nombre del producto	Species	Source	Image

HY-P701768

	RIPK1 Protein, Human (sf9, His, GST) RIPK1; Receptor-interacting serine/threonine-protein kinase 1; Cell death protein RIP; Receptor-interacting protein 1; RIP-1	Human	Sf9 insect cells
	RIPK1 protein is a serine-threonine kinase that centrally regulates TNF-mediated apoptosis, necroptosis, and inflammatory pathways. Functionally, it plays a kinase-dependent role in the regulation of cell death and a kinase-independent scaffolding function in the control of inflammatory signaling and cell survival. RIPK1 Protein, Human (sf9, His, GST) is the recombinant human-derived RIPK1 protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.

HY-P704200

	RIPK1 Protein, Mouse (C-His) Ripk1; Rinp; Rip; Receptor-interacting serine/threonine-protein kinase 1; EC 2.7.11.1; Cell death protein RIP; Receptor-interacting protein 1; RIP-1	Mouse	E. coli
	RIPK1 Protein, Mouse (C-His) is the recombinant mouse-derived RIPK1 protein, expressed by E. coli, with C-6*His tag.

HY-P702936

	RIPK1 Protein, Cynomolgus (Active, sf9, GST) Receptor interacting serine/threonine kinase 1; RIPK1	Cynomolgus	Sf9 insect cells
	RIPK1 Protein, Cynomolgus (Active, sf9, GST) is the recombinant cynomolgus-derived RIPK1, expressed by Sf9 insect cells , with N-GST labeled tag. ,

HY-P703063

	RIPK1 Protein, Canine (Active, sf9, GST) Receptor interacting serine/threonine kinase 1; RIPK1	Dog	Sf9 insect cells
	RIPK1 Protein, Canine (Active, sf9, GST) is the recombinant dog-derived RIPK1, expressed by Sf9 insect cells , with GST labeled tag.

HY-P702935

	RIPK1 Protein, Rat (Active, sf9, GST) Receptor interacting serine/threonine kinase 1 Imported; Ripk1	Rat	Sf9 insect cells
	RIPK1 Protein, Rat (Active, sf9, GST) is the recombinant rat-derived RIPK1, expressed by Sf9 insect cells , with N-GST labeled tag. ,

HY-P703061

	RIPK1 Protein, Cynomolgus (Active, 373a.a, sf9, GST) Receptor interacting serine/threonine kinase 1; RIPK1	Cynomolgus	Sf9 insect cells
	RIPK1 Protein, Cynomolgus (Active, 373a.a, sf9, GST) is the recombinant cynomolgus-derived RIPK1, expressed by Sf9 insect cells , with GST labeled tag.

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Host:	Rabbit (2)
Reactivity:	Human (2) Rat (1) Mouse (1)
Application:	WB (2) FC (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Nombre del producto	Application	Reactivity	Image

HY-P80313

	RIP Antibody (YA091) RIP1, RIPK1, Receptor-interacting protein kinase 1	WB, FC	Human
	RIP Antibody (YA091) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RIP.

HY-P810740

	Cleaved-RIP (Asp324) Antibody (YA9983) RIP, RIP1, RIPK1, Receptor-interacting serine/threonine-protein kinase 1, Cell death protein RIP, Receptor-interacting protein 1, RIP-1	WB	Human, Mouse, Rat
	Cleaved-RIP (Asp324) Antibody (YA9983) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to Cleaved-RIP (Asp324).

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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