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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

TIM-3 Antibody

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Tim3 (13) Mucin (1) PD-1/PD-L1 (2)
By Research Areas:	Cancer (11) Inflammation/Immunology (4)

Inhibitors & Agonists

Inhibitory Antibodies

Antibodies

Targets Recommended: Tim3 ADC Antibody Antibody-Drug Conjugates (ADCs) Antibody-Oligonucleotide Conjugates (AOCs) ADC Linker PROTAC-Linker Conjugates for PAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99044

Sabatolimab 1 Publications Verification MBG453	Tim3	Inflammation/Immunology
Sabatolimab (MBG453) is a high-affinity, humanized, IgG4 (S228P) antibody targeting *TIM-3, an inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab is a potential immunosuppression agent that can target TIM-3* on immune and myeloid cells .

HY-P990821

Anti-Mouse TIM-3 Antibody (RMT3-23)	Tim3	Inflammation/Immunology
Anti-Mouse TIM-3 Antibody (RMT3-23) is a kind of rat-derived anti-mouse *TIM-3* IgG2a antibody inhibitor. Anti-Mouse TIM-3 Antibody (RMT3-23) blocks Tim-3 binding to phosphatidylserine (PtdSer) and carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1). Anti-Mouse TIM-3 Antibody (RMT3-23) inhibits phagocytosis of apoptotic cells in peritoneal exudate Mac1+ cells. Anti-Mouse TIM-3 Antibody (RMT3-23) can be used for the researches of inflammation and immunology, such as rheumatoid arthritis .

HY-P99827

Cobolimab TSR-022; GSK4069889	Tim3	Cancer
Cobolimab (TSR-022) is an anti-TIM-3 monoclonal antibody. Cobolimab mediates the internalization of TIM3 with an IC₅₀ value of 0.4464 nM. Cobolimab has potential application in solid tumors and non-small cell lung cancer (NSCLC) .

HY-P990004

Anti-Mouse TIM-3 Antibody (B8.2C12)	Tim3	Inflammation/Immunology Cancer
Anti-Mouse TIM-3 Antibody (B8.2C12) is an anti-mouse *TIM-3* IgG1 monoclonal antibody. Anti-Mouse TIM-3 Antibody (B8.2C12) can block the binding of Tim-3 with Phosphatidylserine (PtdSer) and CEACAM1 without interfering with the binding to Galectin-9. Anti-Mouse TIM-3 Antibody (B8.2C12) can inhibit tumor growth and activate tumor infiltrating CD8 ⁺ T cells. Anti-Mouse TIM-3 Antibody (B8.2C12) can be used for studying cancer such as breast cancer and colon cancer and constructing experimental autoimmune encephalomyelitis (EAE) models .

HY-P99962

Surzebiclimab BGB-A425	Mucin	Cancer
Surzebiclimab (BGB-A425) is a humanized IgG1-variant monoclonal antibody against T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). Surzebiclimab binds to the extracellular domain of human Tim-3 with high affinity (K_D=0.36 nM) and specificity. Surzebiclimab can be used in research of cancer .

HY-P991396

LY-3321367	Tim3	Cancer
LY-3321367 is a human monoclonal antibody (mAb) targeting *TIM-3/HAVCR2/CD366*. LY-3321367 can be used in solid tumors research .

HY-P991449

LY3415244	PD-1/PD-L1 Tim3	Cancer
LY3415244 is a human bispecific antibody (bsAb) targeting B7-H1/PD-L1/CD274 & TIM-3/HAVCR2/CD366. LY3415244 can be used in advanced solid tumors research .

HY-P991198

M6903	Tim3	Cancer
M6903 is a humanized monoclonal IgG2 antibody targeting T cell immunoglobulin and mucin domain-3 (TIM-3) (KD for human TIM-3 is 2.3 nM). M6903 binds to *TIM-3, blocking the binding of TIM-3* to phosphatidylserine (PtdSer), carcinoembryonic antigen cell adhesion-related molecule 1 (CEACAM1), and galectin 9 (Gal-9), thus relieving TIM-3-mediated T cell inhibition and exerting the activities of activating antigen-specific T cells and enhancing anti-tumor immunity. M6903 is promising for research of cancers .

HY-P991395

TQB2618	Tim3	Cancer
TQB2618 is a human IgG4 monoclonal antibody (mAb) targeting *TIM-3/HAVCR2/CD366*. TQB2618 activates immune cell function and induces significant anti-tumor activity when used in combination with anti-PD-1 agents .

HY-P991397

Sym023	Tim3	Cancer
Sym023 is a human monoclonal antibody (mAb) targeting *TIM-3/HAVCR2/CD366*. Sym023 enhances immunostimulatory and anti-tumor activities. Sym023 can be used in Non-small cell lung cancer, Solid tumors and Lymphoma research .

HY-P990716

Sabestomig AZD7789	PD-1/PD-L1 Tim3	Inflammation/Immunology
Sabestomig (AZD7789) is a monovalent bispecific antibody targeting PD-1 and *TIM-3. Sabestomig binds to PD-1 and an epitope in the TIM-3* IgV domain outside the phosphatidylserine-binding cleft, thereby precisely regulating immune responses. Sabestomig promotes IL-2 production, efferocytosis and cross-presentation of tumor antigens, and enhances the release of anti-tumor T cell cytokines, cytotoxicity, and secretion of IFN-γ. Sabestomig inhibits the growth of solid tumors, prolongs the duration of tumor suppression, and significantly enhances anti-tumor responses following anti-PD-1 therapy. Sabestomig has been used in studies related to non-small cell lung cancer and classical Hodgkin lymphoma .

HY-P992460

SHR-1702	Tim3	Cancer
SHR-1702 is a monoclonal antibody targeting *TIM-3, which specifically binds to and blocks the TIM-3* signaling pathway. SHR-1702 restores the function of immune cells and inhibits the proliferation process of malignant cells. SHR-1702 is mainly used in relevant research on acute myeloid leukemia and myelodysplastic syndromes .

HY-P992398

LBL-003	Tim3	Cancer
LBL-003 is a fully human monoclonal antibody targeting *TIM-3*. LBL-003 can be used for cancer research.

HY-P992454

S095018	Tim3	Cancer
S095018 (Sym023) is a human IgG2-type inhibitor targeting T cell immunoglobulin and *TIM-3. S095018 competitively blocks the binding of multiple ligands such as Gal-9 and phosphatidylserine to TIM-3. S095018 stimulates the anti-tumor activity of T cells, dendritic cells and macrophages, and exhibits good safety both as a monotherapy and in combination with the anti-PD-1* antibody Sym021. S095018 also induces an increase in the density of CD8 ⁺T cells in the tumor microenvironment, and upregulates gene signatures associated with IFN-γ signaling, antigen presentation and T cell activation. S095018 can be used for the research of advanced/metastatic recurrent biliary tract cancer .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99044

Sabatolimab 1 Publications Verification MBG453	Tim3	Inflammation/Immunology
Sabatolimab (MBG453) is a high-affinity, humanized, IgG4 (S228P) antibody targeting *TIM-3, an inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab is a potential immunosuppression agent that can target TIM-3* on immune and myeloid cells .

HY-P990821

Anti-Mouse TIM-3 Antibody (RMT3-23)	Tim3	Inflammation/Immunology
Anti-Mouse TIM-3 Antibody (RMT3-23) is a kind of rat-derived anti-mouse *TIM-3* IgG2a antibody inhibitor. Anti-Mouse TIM-3 Antibody (RMT3-23) blocks Tim-3 binding to phosphatidylserine (PtdSer) and carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1). Anti-Mouse TIM-3 Antibody (RMT3-23) inhibits phagocytosis of apoptotic cells in peritoneal exudate Mac1+ cells. Anti-Mouse TIM-3 Antibody (RMT3-23) can be used for the researches of inflammation and immunology, such as rheumatoid arthritis .

HY-P99827

Cobolimab TSR-022; GSK4069889	Tim3	Cancer
Cobolimab (TSR-022) is an anti-TIM-3 monoclonal antibody. Cobolimab mediates the internalization of TIM3 with an IC₅₀ value of 0.4464 nM. Cobolimab has potential application in solid tumors and non-small cell lung cancer (NSCLC) .

HY-P990004

Anti-Mouse TIM-3 Antibody (B8.2C12)	Tim3	Inflammation/Immunology Cancer
Anti-Mouse TIM-3 Antibody (B8.2C12) is an anti-mouse *TIM-3* IgG1 monoclonal antibody. Anti-Mouse TIM-3 Antibody (B8.2C12) can block the binding of Tim-3 with Phosphatidylserine (PtdSer) and CEACAM1 without interfering with the binding to Galectin-9. Anti-Mouse TIM-3 Antibody (B8.2C12) can inhibit tumor growth and activate tumor infiltrating CD8 ⁺ T cells. Anti-Mouse TIM-3 Antibody (B8.2C12) can be used for studying cancer such as breast cancer and colon cancer and constructing experimental autoimmune encephalomyelitis (EAE) models .

HY-P99962

Surzebiclimab BGB-A425	Mucin	Cancer
Surzebiclimab (BGB-A425) is a humanized IgG1-variant monoclonal antibody against T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). Surzebiclimab binds to the extracellular domain of human Tim-3 with high affinity (K_D=0.36 nM) and specificity. Surzebiclimab can be used in research of cancer .

HY-P991396

LY-3321367	Tim3	Cancer
LY-3321367 is a human monoclonal antibody (mAb) targeting *TIM-3/HAVCR2/CD366*. LY-3321367 can be used in solid tumors research .

HY-P991449

LY3415244	PD-1/PD-L1 Tim3	Cancer
LY3415244 is a human bispecific antibody (bsAb) targeting B7-H1/PD-L1/CD274 & TIM-3/HAVCR2/CD366. LY3415244 can be used in advanced solid tumors research .

HY-P991198

M6903	Tim3	Cancer
M6903 is a humanized monoclonal IgG2 antibody targeting T cell immunoglobulin and mucin domain-3 (TIM-3) (KD for human TIM-3 is 2.3 nM). M6903 binds to *TIM-3, blocking the binding of TIM-3* to phosphatidylserine (PtdSer), carcinoembryonic antigen cell adhesion-related molecule 1 (CEACAM1), and galectin 9 (Gal-9), thus relieving TIM-3-mediated T cell inhibition and exerting the activities of activating antigen-specific T cells and enhancing anti-tumor immunity. M6903 is promising for research of cancers .

HY-P991395

TQB2618	Tim3	Cancer
TQB2618 is a human IgG4 monoclonal antibody (mAb) targeting *TIM-3/HAVCR2/CD366*. TQB2618 activates immune cell function and induces significant anti-tumor activity when used in combination with anti-PD-1 agents .

HY-P991397

Sym023	Tim3	Cancer
Sym023 is a human monoclonal antibody (mAb) targeting *TIM-3/HAVCR2/CD366*. Sym023 enhances immunostimulatory and anti-tumor activities. Sym023 can be used in Non-small cell lung cancer, Solid tumors and Lymphoma research .

HY-P990716

Sabestomig AZD7789	PD-1/PD-L1 Tim3	Inflammation/Immunology
Sabestomig (AZD7789) is a monovalent bispecific antibody targeting PD-1 and *TIM-3. Sabestomig binds to PD-1 and an epitope in the TIM-3* IgV domain outside the phosphatidylserine-binding cleft, thereby precisely regulating immune responses. Sabestomig promotes IL-2 production, efferocytosis and cross-presentation of tumor antigens, and enhances the release of anti-tumor T cell cytokines, cytotoxicity, and secretion of IFN-γ. Sabestomig inhibits the growth of solid tumors, prolongs the duration of tumor suppression, and significantly enhances anti-tumor responses following anti-PD-1 therapy. Sabestomig has been used in studies related to non-small cell lung cancer and classical Hodgkin lymphoma .

HY-P992460

SHR-1702	Tim3	Cancer
SHR-1702 is a monoclonal antibody targeting *TIM-3, which specifically binds to and blocks the TIM-3* signaling pathway. SHR-1702 restores the function of immune cells and inhibits the proliferation process of malignant cells. SHR-1702 is mainly used in relevant research on acute myeloid leukemia and myelodysplastic syndromes .

HY-P992398

LBL-003	Tim3	Cancer
LBL-003 is a fully human monoclonal antibody targeting *TIM-3*. LBL-003 can be used for cancer research.

HY-P992454

S095018	Tim3	Cancer
S095018 (Sym023) is a human IgG2-type inhibitor targeting T cell immunoglobulin and *TIM-3. S095018 competitively blocks the binding of multiple ligands such as Gal-9 and phosphatidylserine to TIM-3. S095018 stimulates the anti-tumor activity of T cells, dendritic cells and macrophages, and exhibits good safety both as a monotherapy and in combination with the anti-PD-1* antibody Sym021. S095018 also induces an increase in the density of CD8 ⁺T cells in the tumor microenvironment, and upregulates gene signatures associated with IFN-γ signaling, antigen presentation and T cell activation. S095018 can be used for the research of advanced/metastatic recurrent biliary tract cancer .

Host:	Mouse (4)
Reactivity:	Human (4)
Application:	IHC-P (1) ICC/IF (3) WB (1) FC (3) ELISA (3)
Isotype:	IgG (1) IgG1 (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84991

	TIM3 Antibody (YA4683) TIM3; CD366; KIM-3; SPTCL; TIMD3; TIM-3; TIMD-3; HAVcr-2; CD366 nanobody; TIM-3 nanobody;	ELISA	Human
	TIM3 Antibody (YA4683) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to TIM3.

HY-P84683

	TIM3 Antibody (YA4380) HAVCR2; CD366; KIM-3; TIMD3; TIM-3; TIMD-3; HAVcr-2	ICC/IF, FC, ELISA	Human
	TIM3 Antibody (YA4380) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TIM3.

HY-P84683A

	TIM3 Antibody (YA4380)(PBS only) HAVCR2; CD366; KIM-3; TIMD3; TIM-3; TIMD-3; HAVcr-2	ICC/IF, FC, ELISA	Human
	TIM3 Antibody (YA4380) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TIM3.

HY-P81703

	TIM3 Antibody (YA1448) 1 Publications Verification CD366 Antibody; FLJ14428 Antibody; HAVcr-2 Antibody; Havcr2 Antibody; HAVR2_HUMAN Antibody; Hepatitis A virus cellular receptor 2 Antibody; Kidney injury molecule 3 Antibody; KIM 3 Antibody; KIM3 Antibody; T cell immunoglobulin and mucin domain containing 3 Antibody; T cell immunoglobulin mucin 3 Antibody; T-cell immunoglobulin and mucin domain-containing protein 3 Antibody; T-cell immunoglobulin mucin family member 3 Antibody; T-cell immunoglobulin mucin receptor 3 Antibody; T-cell membrane protein 3 Antibody; TIM 3 Antibody; TIM-3 Antibody; TIM3 Antibody; TIMD-3 Antibody; TIMD3 Antibody;	WB, IHC-P, ICC/IF, FC	Human
	TIM3 Antibody (YA1448) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to TIM3.

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