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Sabestomig

(Synonyms: AZD7789)
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Based on 1 Customer Validation

Sabestomig (AZD7789) is a monovalent bispecific antibody targeting PD-1 and TIM-3. Sabestomig binds to PD-1 and an epitope in the TIM-3 IgV domain outside the phosphatidylserine-binding cleft, thereby precisely regulating immune responses. Sabestomig promotes IL-2 production, efferocytosis and cross-presentation of tumor antigens, and enhances the release of anti-tumor T cell cytokines, cytotoxicity, and secretion of IFN-γ. Sabestomig inhibits the growth of solid tumors, prolongs the duration of tumor suppression, and significantly enhances anti-tumor responses following anti-PD-1 therapy. Sabestomig has been used in studies related to non-small cell lung cancer and classical Hodgkin lymphoma.

For research use only. We do not sell to patients.

  • Purity: 98.33%
  • CAS No.: 2648346-74-9
  • Molecular Weight:146.032 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Sabestomig
  • Experimental Validation Results for Sabestomig
  • Experimental Validation Results for Sabestomig
  • Sabestomig Chemical Structure
    Sabestomig Chemical Structure
CAS No.: 2648346-74-9
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Sabestomig Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    IgG1-lambda-kappa

  • 1/16

    Immobilized PD-1 Protein, Human (HEK293, His, HY-P7396) can bind Sabestomig. The EC50 for this effect is 23.46 ng/mL.

  • 1/16

    Immobilized TIM-3/HAVCR2 Protein, Human (HEK293, His HY-P70482) can bind Sabestomig. The EC50 for this effect is 32.83 ng/mL.

  • Sabestomig Chemical Structure
    1/16
  • Sabestomig
  • Immobilized PD-1 Protein, Human (HEK293, His, HY-P7396) can bind Sabestomig. The EC50 for this effect is 23.46 ng/mL.
  • Immobilized TIM-3/HAVCR2 Protein, Human (HEK293, His HY-P70482) can bind Sabestomig. The EC50 for this effect is 32.83 ng/mL.
  • IgG1-lambda-kappa