2. Signaling Pathways
  3. Immunology/Inflammation
  4. Mucin

Mucin

Mucin is a class of high molecular weight glycoproteins that play crucial roles in protecting and lubricating mucosal surfaces. Mucin is characterized by a large number of O-glycosylated serine and threonine residues. Mucin can be classified into secreted mucins and membrane bounded mucins. For example, MUC1 is often overexpressed in many cancers and can interact with cell surface receptors and extracellular matrix components, affecting cell adhesion, migration and signal transduction. MUC2 is the main component of intestinal mucus, forming a physical barrier to protect the intestinal epithelium from pathogens and toxins. Different mucin subtypes have distinct expression patterns and functions in various tissues and organs. Mucin can also interact with microorganisms, participating in the regulation of the host-microbe interaction[1][2].

Mucin Isoform Specific Products:

Mucin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P99634
    Gatipotuzumab
    		99.204%
    Gatipotuzumab (PankoMab) is a humanized monoclonal antibody which recognizes the tumor-specific epitope of mucin-1 (TA-MUC1). Gatipotuzumab reveals a potent tumor-specific antibody-dependent cell cytotoxicity (ADCC).
    Gatipotuzumab
  • HY-177442
    DS-3939a
    		Inhibitor 99.15%
    DS-3939a (DS-3939) is an anti-TA-MUC1 (tumor-associated mucin-1) antibody-drug conjugate (ADC). DS-3939a consists of a humanized anti-TA-MUC1 IgG1 monoclonal antibody Gatipotuzumab ( HY-P99634), a stable and cleavable tetrapeptide-based linker (Gly-Gly-Phe-Gly), and a DNA topoisomerase I inhibitor payload (DXd) (HY-13631D), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). DS-3939a inhibits the growth of TA-MUC1-positive cancer cells (CFPAC-1, NCI-H2110) by inducing DNA damage and apoptosis. DS-3939a exhibits significant antitumor activity in a variety of TA-MUC1-expressing advanced solid tumors. DS-3939a can be used for the study of TA-MUC1-expressing advanced cancers.
    DS-3939a
  • HY-160109
    Ac5GalNTGc
    		98.54%
    Ac5GalNTGc is a potent, peracetylated C-2 thioglycolyl-substituted GalNAc analog that efficiently inhibits mucin-type O-glycan biosynthesis. Ac5GalNTGc reduces leukocyte sialyl-Lewis-X expression and inhibits L-/P-selectin mediated rolling under flow, as well as P-selectin dependent leukocyte-platelet adhesion. Ac5GalNTGc exhibits anti-inflammatory activity in a thioglycollate-induced acute peritonitis model. Ac5GalNTGc can be used for studies of O-glycan/mucin biology, inflammation, and related translational research.
    Ac5GalNTGc
  • HY-B0264
    Guaifenesin
    		99.86%
    Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough.
    Guaifenesin
  • HY-P99237
    Sofituzumab
    		Inhibitor
    Sofituzumab (MMUC 1206A) is an anti-MUC16 antibody with a Kd of 0.3-0.9 nM. Sofituzumab can bind multiple adjacent antibody molecules to the repeat sequences of the same MUC16 molecule. Sofituzumab exhibits no anti-tumor activity in the HPAC pancreatic adenocarcinoma xenograft model.
    Sofituzumab
  • HY-W746270
    Guaimesal
    Guaimesal is a new antiphlogistic and mucus-regulating agent. Guaimesal improves bronchitis symptoms.
    Guaimesal
  • HY-P992091
    Nacolomab
    		Inhibitor
    Nacolomab is an anti-human monoclonal antibody targeting MUC1/CD227. Nacolomab can be used for the research of cancer.
    Nacolomab
  • HY-P992131
    Sacomitatug
    		Inhibitor
    Sacomitatug is a humanized IgG1-κ monoclonal antibody targeting mucin 1 (MUC1). Sacomitatug exerts anti-tumor effects by blocking MUC1-mediated tumor proliferation signals and activating immune effectors.
    Sacomitatug
  • HY-P99732
    Minretumomab
    		Inhibitor
    Minretumomab (CC-49) is a murine monoclonal antibody against TAG-72 (tumor-associated glycoprotein 72). Minretumomab is used in cancer and immunity research.
    Minretumomab
  • HY-NP159
    House Dust Mite Extract, from D.farinae
    		Activator
    House Dust Mite Extract, from D.farinae is a house dust mite allergen extract derived from Dermatophagoides farinae. House Dust Mite Extract, from D.farinae significantly increases the levels of cytokines (IL-4, IL-5, IL-6) in bronchoalveolar lavage fluid. House Dust Mite Extract, from D.farinae upregulates the overexpression of MUC5AC. House Dust Mite Extract, from D.farinae induces allergic asthma and pulmonary inflammation.
    House Dust Mite Extract, from D.farinae
  • HY-P99591
    Sontuzumab
    		Inhibitor 99.66%
    Sontuzumab (AS1402) is a humanizedised IgG1κ MUC1 specific monoclonal antibody. Sontuzumab binds the extracellular MUC1 peptide sequence PDTR with a Kd of ~1 nM. Sontuzumab can be used for the research of breast cancer.
    Sontuzumab
  • HY-P2508
    MUC1, mucin core
    MUC1, mucin core is the region of the MUC1 mucin core. MUC1 is a type I transmembrane glycoprotein, and is overexpressed and aberrantly glycosylated in carcinoma cells. MUC1, mucin core protein binds to domain 1 of ICAM-1.
    MUC1, mucin core
  • HY-N1510
    Kaempferol 3-O-gentiobioside
    		Inhibitor 99.88%
    Kaempferol 3-O-gentiobioside is an orally active flavonoid, with a Ka value of 57 µM against human NOTCH1 and an IC50 value of 50 μM against α-glucosidase. Kaempferol 3-O-gentiobioside inhibits the NOTCH signaling pathway. It downregulates the expression of TLR4 and NLRP3, and suppresses the activation and nuclear translocation of NF-κB. Kaempferol 3-O-gentiobioside inhibits the expression of MUC5AC, reduces nitrite and ROS levels, and attenuates excessive mucus secretion. It exhibits antibacterial activity, reducing the formation and growth of MRSA biofilms. Kaempferol 3-O-gentiobioside blocks the TGF-β/ALK5/Smad signaling pathway and inhibits epithelial-mesenchymal transition. It suppresses the proliferation, migration, invasion and metastatic growth of tumor cells. Kaempferol 3-O-gentiobioside alleviates airway inflammation and mucus hypersecretion in mice with allergic asthma. It reduces the volume of ovarian cancer xenografts in mice. Kaempferol 3-O-gentiobioside can be used in research related to allergic asthma, diabetes, MRSA infection, breast cancer, gastric cancer and ovarian cancer.
    Kaempferol 3-O-gentiobioside
  • HY-168973
    Fexlamose
    		Inhibitor 99.93%
    Fexlamose (AER-01) is a thiol-modified carbohydrate agent with mucolytic property. Fexlamose cleaves disulfides to cause mucolysis. Fexlamose can be used for researchs of chronic obstructive pulmonary disease (COPD) and muco-obstructive lung diseases (MOLD).
    Fexlamose
  • HY-P99962
    Surzebiclimab
    Surzebiclimab (BGB-A425) is a humanized IgG1-variant monoclonal antibody against T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). Surzebiclimab binds to the extracellular domain of human Tim-3 with high affinity (KD=0.36 nM) and specificity. Surzebiclimab can be used in research of cancer.
    Surzebiclimab
  • HY-171270
    Clivatuzumab-MMAE
    		98.71%
    Clivatuzumab-MMAE is an antibody-drug conjugate (ADC) (Clivatuzumab antibody (HY-P99968), Linker: VC linker, Payload: MMAE (HY-15162)). Anetumab is a humanized anti-mucin monoclonal antibody.
    Clivatuzumab-MMAE
  • HY-P99968
    Clivatuzumab
    		Inhibitor ≥99.0%
    Clivatuzumab is a humanized anti-mucin monoclonal antibody targeting an epitope in the MUC1 antigen expressed in most pancreatic cancers.
    Clivatuzumab
  • HY-P99362
    Ensituximab
    		Inhibitor 99.93%
    Ensituximab (NEO-102; NPC-1C) is a chimeric monoclonal IgG1 antibody targeting a variant of MUC5AC. Ensituximab shows specificity to colorectal and pancreatic cancer.
    Ensituximab
  • HY-P990831
    Anti-MUC1/CD227 Antibody (C595 (NCRC48))
    		Inhibitor
    Anti-MUC1/CD227 Antibody (C595 (NCRC48)) is a kind of mouse IgG3 κ chimeric antibody inhibitor, targeting to human MUC1/CD227. Anti-MUC1/CD227 Antibody (C595 (NCRC48)) specifically recognizes and binds to the MUC1 protein, which is overexpressed and abnormally glycosylated on the surface of tumor cells, thereby precisely killing cancer cells. Anti-MUC1/CD227 Antibody (C595 (NCRC48)) can be used for the researches of cancer, such as ovarian cancer.
    Anti-MUC1/CD227 Antibody (C595 (NCRC48))
  • HY-P0280
    MUC5AC motif peptide
    		98.97%
    MUC5AC motif peptide is a 16-amino acid fragment of mucin 5.
    MUC5AC motif peptide
Cat. No. Product Name / Synonyms Application Reactivity
Mucin Isoform Comparison

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