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  4. MUC1, mucin core

MUC1, mucin core is the region of the MUC1 mucin core. MUC1 is a type I transmembrane glycoprotein, and is overexpressed and aberrantly glycosylated in carcinoma cells. MUC1, mucin core protein binds to domain 1 of ICAM-1.

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MUC1, mucin core

MUC1, mucin core Chemical Structure

CAS No. : 149205-73-2

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Description

MUC1, mucin core is the region of the MUC1 mucin core. MUC1 is a type I transmembrane glycoprotein, and is overexpressed and aberrantly glycosylated in carcinoma cells. MUC1, mucin core protein binds to domain 1 of ICAM-1[1].

Molecular Weight

1484.70

Formula

C61H101N19O24
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Gly-Val-Thr-Ser-Ala-Pro-Asp-Thr-Arg-Pro-Ala-Pro-Gly-Ser-Thr-Ala
Sequence Shortening

GVTSAPDTRPAPGSTA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (67.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6735 mL 3.3677 mL 6.7354 mL
5 mM 0.1347 mL 0.6735 mL 1.3471 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.6735 mL 3.3677 mL 6.7354 mL 16.8384 mL
5 mM 0.1347 mL 0.6735 mL 1.3471 mL 3.3677 mL
10 mM 0.0674 mL 0.3368 mL 0.6735 mL 1.6838 mL
15 mM 0.0449 mL 0.2245 mL 0.4490 mL 1.1226 mL
20 mM 0.0337 mL 0.1684 mL 0.3368 mL 0.8419 mL
25 mM 0.0269 mL 0.1347 mL 0.2694 mL 0.6735 mL
30 mM 0.0225 mL 0.1123 mL 0.2245 mL 0.5613 mL
40 mM 0.0168 mL 0.0842 mL 0.1684 mL 0.4210 mL
50 mM 0.0135 mL 0.0674 mL 0.1347 mL 0.3368 mL
60 mM 0.0112 mL 0.0561 mL 0.1123 mL 0.2806 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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MUC1, mucin core Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MUC1, mucin core149205-73-2MucinO-glycosylationglycosylatedtransmembraneglycoproteinserinesthreoninesoverexpresscancerICAM-1Inhibitorinhibitorinhibit

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