serines

By Targets:	5-HT Receptor (1) Adrenergic Receptor (1) Akt (1) Amino Acid Derivatives (79) Anaplastic lymphoma kinase (ALK) (2) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (2) Antifolate (3) Apoptosis (20) ASCT (3) ATM/ATR (2) Aurora Kinase (1) Autophagy (6) Bacterial (10) Bcl-2 Family (4) Beta-lactamase (4) Biochemical Assay Reagents (2) c-Fms (1) c-Kit (1) c-Met/HGFR (2) Calcineurin (1) Caspase (3) Cathepsin (7) CDK (8) Complement System (2) COX (3) Dengue virus (1) Dipeptidyl Peptidase (2) Dopamine Transporter (1) EAAT (2) EGFR (1) Elastase (3) Endogenous Metabolite (27) Eukaryotic Initiation Factor (eIF) (1) FAAH (6) Factor Xa (5) FAK (2) Flavivirus (4) FLT3 (1) Fluorescent Dye (3) Fungal (2) GCGR (2) GSK-3 (2) HCV (2) HCV Protease (2) HDAC (1) HPV (1) HSP (2) IGF-1R (1) IKK (3) Influenza Virus (2) Insulin Receptor (2) Interleukin Related (1) Isotope-Labeled Compounds (21) JAK (1) LIM Kinase (LIMK) (1) Liposome (8) Lipoxygenase (1) MAGL (6) MAP4K (9) MAPKAPK2 (MK2) (2) mGluR (2) Mixed Lineage Kinase (2) MNK (1) Mucin (1) NF-κB (4) NO Synthase (1) PAI-1 (5) PD-1/PD-L1 (1) PDGFR (1) Penicillin-binding protein (PBP) (1) Phosphatase (4) Phosphoglycerate Dehydrogenase (PHGDH) (7) Phospholipase (2) Pim (1) PKA (2) PKC (1) Prolyl Endopeptidase (PREP) (1) PROTACs (2) Protease Activated Receptor (PAR) (3) Proteasome (1) Ras (2) RIP kinase (6) SARS-CoV (6) Ser/Thr Protease (54) SGK (2) SHMT (5) Small Interfering RNA (siRNA) (2) SRPK (2) Thrombin (4) TMV (2) TNF Receptor (3) VEGFR (2) Virus Protease (4) Wnt (1)
By Research Areas:	Cancer (113) Cardiovascular Disease (17) Endocrinology (4) Infection (34) Inflammation/Immunology (44) Metabolic Disease (29) Neurological Disease (25)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W005308

*N-BOC-DL-serine* methyl ester**	Amino Acid Derivatives	Cancer
N-BOC-DL-serine methyl ester is a Serine derivative. N-BOC-DL-serine methyl ester is used for the synthesis of α,β-dehydro-α-amino acid. N-BOC-DL-serine methyl ester is also used for the synthesis of anti-cancer agent, such as quinazolinone derivative that inhibits PI3K activity, and tricyclic pyrolopyranopyridines that inhibits protein kinase activity .

HY-W048674

Fmoc-Ser(Ac)-OH Fmoc-O-acetyl-L-serine	Amino Acid Derivatives	Infection
Fmoc-Ser(Ac)-OH (Fmoc-O-acetyl-L-serine) is a Serine derivative. Fmoc-Ser(Ac)-OH can be used for the preparation of broad-spectrum coronavirus membrane fusion inhibitor .

HY-153433

Serine Hydrolase inhibitor-21	Others	Neurological Disease
Serine Hydrolase inhibitor-21 (compound 8), a pyridine, is a serine hydrolase inhibitor with a K_i of 429 nM for BuChE. Serine Hydrolase inhibitor-21 has the potential for Alzheimer's disease research .

HY-W039102

N-Fmoc-N,O-dimethyl-L-serine	Amino Acid Derivatives	Cancer
N-Fmoc-N,O-dimethyl-L-serine is a serine derivative that can be used for coibamide A synthesis. Coibamide A is a marine natural product with potent antiproliferative activity against human cancer cells .

HY-P2942

Chymotrypsinogen	Ser/Thr Protease	Inflammation/Immunology
Chymotrypsinogen is an inactive precursor of Chymotrypsin (HY-108910). Chymotrypsin is a serine protease produced by the pancreas .

HY-147278

Manusiran

Small Interfering RNA (siRNA) Ser/Thr Protease Others

Manusiran is a potent TMPRSS6 (transmembrane protease serine 6) synthesis reducer .
HY-147278A

Manusiran sodium

Ser/Thr Protease Small Interfering RNA (siRNA) Others

Manusiran sodium is a potent TMPRSS6 (transmembrane protease serine 6) synthesis reducer .

Manusiran	Small Interfering RNA (siRNA) Ser/Thr Protease	Others
Manusiran is a potent TMPRSS6 (transmembrane protease serine 6) synthesis reducer .

Manusiran sodium	Ser/Thr Protease Small Interfering RNA (siRNA)	Others
Manusiran sodium is a potent TMPRSS6 (transmembrane protease serine 6) synthesis reducer .

HY-108904

Urokinase, Human urine Urokinase-type plasminogen activator; Uronase; Win 22005; Win-Kinase	Ser/Thr Protease	Cardiovascular Disease Cancer
Urokinase (peptidolytic) (EC 3.4.21.73) is a serine protease, an inactive form (zymogen) of the serine protease plasminogen. Activation of plasmin triggers a proteolytic cascade reaction, which in turn participates in thrombolysis or extracellular matrix degradation, implicated in vascular disease and cancer-related research .

HY-119759

Lipoxamycin

Fungal Infection

Lipoxamycin is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC₅₀ of 21 nM .

Lipoxamycin	Fungal	Infection
Lipoxamycin is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC₅₀ of 21 nM .

HY-139097

C12-Sphingosine	Others	Others
C12-Sphingosine is a short-chain Sphingosine homologue. C12-Sphingosine inhibits serine palmitoyltransferase activity in primary cultured cerebellar cells .

HY-E70194

Endoproteinase Glu-C V8 protease; Glu-C	Ser/Thr Protease	Others
Endoproteinase GluC (V8 protease) is a serine proteinase. Endoproteinase GluC is able to hydrolyze some serpins and all classes of mammalian immunoglobulins .

HY-147404

Tilpisertib fosmecarbil GS 5290	Ser/Thr Protease	Inflammation/Immunology
Tilpisertib fosmecarbil is a potent serine/threonine kinase inhibitor. Tilpisertib fosmecarbil has anti-inflammatory activity .

HY-E70200

Recombinant Kex2 protease	Ser/Thr Protease	Others
Recombinant Kex2 protease is a membrane-bound, Ca ²⁺-dependent serine protease. Recombinant Kex2 protease specifically recognize and cleave the carboxyl-terminal peptide bonds of dibasic amino acids .

HY-18522

AA26-9	Phospholipase	Metabolic Disease
AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. AA26-9 targets included serine peptidases, lipases, amidases, esterases, and thioesterases. AA26-9 shows inhibitory activity against approximately 1/3 of the 40+ serine hydrolases detected in immortalized T cell lines .

HY-119759A

Lipoxamycin hemisulfate

Fungal Infection

Lipoxamycin hemisulfate is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC₅₀ of 21 nM .
HY-18544

AA38-3

MAGL FAAH Metabolic Disease

AA38-3 is a serine hydrolase (SH) inhibitor. AA38-3 can inhibit three SHs, ABHD6, ABHD11, and FAAH .

Lipoxamycin hemisulfate	Fungal	Infection
Lipoxamycin hemisulfate is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC₅₀ of 21 nM .

AA38-3	MAGL FAAH	Metabolic Disease
AA38-3 is a serine hydrolase (SH) inhibitor. AA38-3 can inhibit three SHs, ABHD6, ABHD11, and FAAH .

HY-N4332

Rivulariapeptolides 1121	Ser/Thr Protease	Infection Cancer
Rivulariapeptolides 1121 is a high potent and selective serine protease inhibitor with IC₅₀ values of 35.52 nM, 13.24 nM and 48.05 nM for chymotrypsin, elastase and proteinase K, respectively .

HY-P4243

Dansyl-Glu-Gly-Arg-Chloromethylketone	Ser/Thr Protease	Others
Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor, and inhibits serine/threonine proteases. Dansyl-Glu-Gly-Arg-Chloromethylketone inhibits activated porcine factor IX .

HY-113013

Hydroxypyruvic acid β-Hydroxypyruvic acid; 3-Hydroxypyruvic acid	Endogenous Metabolite	Metabolic Disease
Hydroxypyruvic acid (β-Hydroxypyruvic acid) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.

HY-W174279

Tyrphostin 8	EGFR Ras Phosphatase	Metabolic Disease
Tyrphostin 8 is a tyrosine kinase, with an IC₅₀ of 560 μM for EGFR kinase. Tyrphostin 8 is also a GTPase inhibitor. Tyrphostin 8 can inhibit the protein serine/threonine phosphatase calcineurin (IC₅₀=21 μM) .

HY-10865

LY2183240 2 Publications Verification	FAAH Autophagy	Neurological Disease
LY2183240 is a highly potent blocker of anandamide uptake (IC₅₀= 270 pM; K_i=540 nM). LY2183240 is a potent, covalent inhibitor of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) with an IC₅₀ of 12.4 nM. LY2183240 inactivates FAAH by carbamylation of the enzyme's serine nucleophile. LY2183240 also inhibits several other brain serine hydrolases with IC₅₀s of 5.3, 0.09, 8.2 nM for MAG lipase, bh6 and KIAA1363, respectively .

HY-113013A

Hydroxypyruvic acid lithium hydrate β-Hydroxypyruvic acid lithium hydrate; 3-Hydroxypyruvic acid lithium hydrate	Endogenous Metabolite	Metabolic Disease
Hydroxypyruvic acid lithium hydrate (β-Hydroxypyruvic acid lithium hydrate) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid lithium hydrate is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid lithium hydrate is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.

HY-P2990

Enteropeptidase TMPRSS15	Ser/Thr Protease	Metabolic Disease
Enteropeptidase (TMPRSS15), a type II transmembrane serine protease and a physiological activator of trypsinogen. Enteropeptidase is associated with the brush border membrane (BBM) of the enterocytes in the upper small intestine. Trypsinogen is the primary substrate for Enteropeptidase. Enteropeptidase is involved in digestion in humans and animals .

HY-145263

VD2173	Ser/Thr Protease	Cancer
VD2173 is a side chain cyclized macrocyclic peptide inhibitor of *HGF-activating serine* proteases. VD2173 potently inhibits matriptase and hepsin**. VD2173 can be used for the research of lung cancer .

HY-N4331

Rivulariapeptolides 1185	Ser/Thr Protease	Infection Cancer
Rivulariapeptolides 1185 is a high potent and selective serine protease inhibitor with IC₅₀ values of 13.17 nM, 23.59 nM and 55.26 nM for chymotrypsin, elastase and proteinase K, respectively .

HY-N4333

Rivulariapeptolides 988	Ser/Thr Protease	Infection Cancer
Rivulariapeptolides 988 is a high potent and selective serine protease inhibitor with IC₅₀ values of 95.46 nM, 15.29 nM and 85.50 nM for chymotrypsin, elastase and proteinase K, respectively .

HY-134616

Ulinastatin 1 Publications Verification Uristatin	Ser/Thr Protease Apoptosis	Neurological Disease Inflammation/Immunology
Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects .

HY-163347

FXIIa-IN-3	Others	Cardiovascular Disease
FXIIa-IN-3 (Compound 8) is a potent and selective Factor XIIa (FXIIa) inhibitor, with an IC₅₀ of 0.045 μM. FXIIa-IN-3 also exhibits a substantial margin of selectivity against related serine proteases, including FXIa, FXa, and FIXa. FXIIa-IN-3 can be used for the research of thromboembolic diseases .

HY-W141825

N-Acetyl-DL-phenylalanine β-naphthyl ester	Fluorescent Dye	Infection Metabolic Disease
N-Acetyl-DL-phenylalanine β-naphthyl ester is an aromatic amino acid ester, which functions as a chromogenic substrate for chymotrypsin and microbial serine proteases such as subtilisin .

HY-101962

HNMPA	Insulin Receptor	Metabolic Disease
HNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities

HY-123542

ONO-3403	Ser/Thr Protease Apoptosis	Cancer
ONO-3403 is an orally active serine protease inhibitor. ONO-3403 inhibits the production of TNF-α and nitric oxide induced by LPS. ONO-3403 inhibits the cell growth and induces the apoptosis, and has an antitumor effect on malignant tumors .

HY-P2974

Elastase, Porcine pancreas EC 3.2.1.35; Pancreatopeptidase E	Elastase	Metabolic Disease
Elastase, Porcine pancreas (EC 3.2.1.35) is a single polypeptide chain of 240 amino acid residues, derived from pig pancreas. Elastase, Porcine pancreas is a serine protease that can hydrolyze proteins and polypeptide. Elastase from porcine pancreas can induce emphysema in hamsters .

HY-136069

Xeruborbactam QPX7728	Bacterial	Infection
Xeruborbactam (QPX7728) is a potent, ultra-broad-spectrum boronic acid beta-lactamase inhibitor. Xeruborbactam inhibits key serine and metallo beta-lactamases at a nano molar range .

HY-148072

MM3122	SARS-CoV	Infection
MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC₅₀ value of 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells .

HY-136072

Xeruborbactam disodium QPX7728 disodium	Bacterial	Infection
Xeruborbactam (QPX7728) disodium is a potent, ultra-broad-spectrum boronic acid beta-lactamase inhibitor. Xeruborbactam disodium inhibits key serine and metallo beta-lactamases at a nano molar range .

HY-12834A

MK2-IN-1 hydrochloride 3 Publications Verification	MAPKAPK2 (MK2) HSP	Cancer
MK2-IN-1 hydrochloride (compound 1) is a potent and selecitve MAPKAPK2 (MK2) inhibitor with an IC₅₀ of 0.11 uM for MK2 and an EC₅₀ of 0.35 uM for pHSP27. MK2-IN-1 hydrochloride impaires the phosphorylation level of serine residues in the Tfcp2l1 protein .

HY-12834

MK2-IN-1	MAPKAPK2 (MK2) HSP	Cancer
MK2-IN-1 (compound 1) is a potent and selecitve MAPKAPK2 (MK2) inhibitor with an IC₅₀ of 0.11 uM for MK2 and an EC₅₀ of 0.35 uM for pHSP27. MK2-IN-1 impaires the phosphorylation level of serine residues in the Tfcp2l1 protein .

HY-103463

SA57	FAAH MAGL	Neurological Disease
SA57 is a potent, selective FAAH inhibitor with IC₅₀s of 3.2 nM and 1.9 nM for mouse and human FAAH. SA57 also inhibits the 2-arachidonoylglycerol hydrolases MAGL (IC₅₀s of 410 nM and 1.4 μM for mouse and human MAGL) and mouse α/β-hydrolase domain-containing protein 6 (mABHD6; IC₅₀ of 850 nM), but not other brain serine hydrolases .

HY-161094

Metallo-β-lactamase-IN-12	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-12 is a dual inhibitor of metal β-lactamases (MβLs (NDM-1, IMP-1)) and serine β-lactamases (SβLs (OXA-48, KPC-2)), with IC₅₀ values of 0.64 μM, 1.32 μM, 1.01 μM, and 0.57 μM, respectively. Metallo-β-lactamase-IN-12 has antibacterial activity .

HY-145860

PHGDH-IN-2	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
PHGDH-IN-2 is a potent and NAD ⁺ competitive PHGDH inhibitor with an IC₅₀ of 5.2 µM. PHGDH-IN-2 inhibits the serine synthetic pathway in MDA-MB-468 cells. PHGDH-IN-2 inhibits the growth of PHGDH-dependent cancer cells .

HY-18234

Leupeptin	Ser/Thr Protease Virus Protease Cathepsin	Infection Inflammation/Immunology
Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits *serine, cysteine* and threonine proteases. Leupeptin inhibits M ^pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity .

HY-125351

SPT-IN-1	Others	Metabolic Disease
SPT-IN-1 (compound 1) is an orally active and potent SPT (serine palmitoyl transferase) inhibitor, with an IC₅₀ of 5.19 nM for hSPT1. SPT-IN-1 can be used for type 2 diabetes and dyslipidemia research .

HY-124379

TPCK 1 Publications Verification L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK	Ser/Thr Protease HPV	Inflammation/Immunology Cancer
TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is a potent serine protease inhibitor that reacts with the retinoblastoma protein (RB)-binding core of HPV-18 E7 protein and abolish its RB-binding capability. TPCK is able to modify E7 protein in live keratinocytes following its addition to the culture medium .

HY-137458

Vevorisertib ARQ 751	Akt Ser/Thr Protease	Cancer
Vevorisertib (ARQ 751) is an orally active, potent and selective pan-AKT serine/threonine kinase inhibitor against AKT1 (IC₅₀=0.55 nM), AKT2 (IC₅₀=0.81 nM), and AKT3 (IC₅₀=1.31 nM). Vevorisertib, as a single agent or in combination with other anti-cancer agents, can be used for the research of solid tumors with PIK3CA / AKT / PTEN mutations .

HY-18234A

Leupeptin hemisulfate 25+ Cited Publications	Cathepsin Ser/Thr Protease Virus Protease	Infection Inflammation/Immunology
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits *serine, cysteine* and threonine proteases. Leupeptin hemisulfate inhibits M ^pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity .

HY-N0650S7

*L-Serine-d2* (-)-Serine-d₂; (S)-Serine-d₂	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
L-Serine-d₂ is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S8

*L-Serine-d3* (-)-Serine-d₃; (S)-Serine-d₃	Endogenous Metabolite	Cancer
L-Serine-d₃ is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S11

*L-Serine-d7* (-)-Serine-d₇; (S)-Serine-d₇	Isotope-Labeled Compounds Endogenous Metabolite
L-Serine-d₇ is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-W718796

*DL-Serine-15N*	Isotope-Labeled Compounds TMV	Cancer
DL-Serine- ¹⁵N is ¹⁵N-labeled DL-Serine (HY-Y0507) DL-Serine, a fundamental metabolite, is a mixture of D-Serine and L-Serine. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV).

HY-N0650S1

*L-Serine-13C* (-)-Serine-¹³C; (S)-Serine-¹³C	Endogenous Metabolite	Cancer
L-Serine- ¹³C is the ¹³C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

Cat. No.	Product Name

HY-L164

Serine/Threonine Kinase Inhibitor Library

1267 Compounds compounds

Protein serine/threonine kinases (PSKs) are protein kinases that use ATP as a high-energy donor molecule to transfer phosphate groups to serine/threonine residues of target protein. As an important signal transduction regulator, serine/threonine kinases can affect the function of target proteins by disrupting enzyme activity or binding of target proteins to other proteins. Serine/threonine kinases are involved in the regulation of immune response, cell proliferation, differentiation, apoptosis and other physiological processes. Serine/threonine kinase inhibitors are an important class of compounds that have been widely studied in cancer, chronic inflammation, autoimmune diseases, aging and other diseases.

MCE designs a unique collection of 1267 serine/threonine kinase inhibitors, mainly targeting the receptor PKA, Akt, PKC, MAPK/ERK, etc, which is an effective tool for development and research of anti-cancer, anti-chronic inflammatory diseases, anti-autoimmune diseases and anti-aging compounds.

HY-L081

Phosphatase Inhibitor Library

132 compounds

Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc.

Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action.

MCE supplies a unique collection of 132 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.

HY-L024

Histone Modification Research Compound Library

614 compounds

A histone modification, a covalent post-translational modification (PTM) to histone proteins, includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation, etc. In general, histone modifications are catalyzed by specific enzymes that act predominantly at the histone N-terminal tails involving amino acids such as lysine or arginine, as well as serine, threonine, tyrosine, etc. The PTMs made to histones can impact gene expression by altering chromatin structure or recruiting histone modifiers. Histone modifications act in diverse biological processes such as transcriptional activation/inactivation, chromosome packaging, and DNA damage/repair. Deregulation of histone modification contributes to many diseases, including cancer and autoimmune diseases.

MCE owns a unique collection of 614 bioactive compounds targeting Epigenetic Reader Domain, HDAC, Histone Acetyltransferase, Histone Demethylase, Histone Methyltransferase, Sirtuin, etc. Histone Modification Research Compound Library is a useful tool for histone modification research and drug screening.

HY-L018

TGF-beta/Smad Compound Library

223 compounds

The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc.

MCE designs a unique collection of 223 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.

Cat. No.	Product Name	Type

HY-W141825

N-Acetyl-DL-phenylalanine β-naphthyl ester	Chromogenic Substrates
N-Acetyl-DL-phenylalanine β-naphthyl ester is an aromatic amino acid ester, which functions as a chromogenic substrate for chymotrypsin and microbial serine proteases such as subtilisin .

Cat. No.	Product Name	Type

HY-141613

*1,2-Dioleoyl-sn-glycero-3-phospho-L-serine* sodium** DOPS-NA	Drug Delivery
1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium is a ubstitute for Phosphoserine/phosphatidylserine. 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium can be used in lipid mixtures with DOPC and DOPE as effective nontoxic and nonviral DNA vectors .

HY-N4254

Distearoylphosphatidylserine DSPS	Drug Delivery
Distearoylphosphatidylserine (DSPS) acts as a monolayer. Phosphatidylserine is a phospholipid with a polar serine found in phosphoester linkage to diacylglycerol .

HY-108910

Chymotrypsin EC 3.4.21.1; Chymotrypsin A	Biochemical Assay Reagents
Chymotrypsin (Chymotrypsin A) is a serine protease produced by the pancreas. Chymotrypsin cleaves protein chains at the carboxyl side of aromatic amino acids .

HY-P2990

Enteropeptidase TMPRSS15	Biochemical Assay Reagents
Enteropeptidase (TMPRSS15), a type II transmembrane serine protease and a physiological activator of trypsinogen. Enteropeptidase is associated with the brush border membrane (BBM) of the enterocytes in the upper small intestine. Trypsinogen is the primary substrate for Enteropeptidase. Enteropeptidase is involved in digestion in humans and animals .

HY-E70178

Protein O-Glucosyltransferase 1 EC:2.4.2.63; POGLUT1	Enzyme Substrates
Protein O-Glucosyltransferase 1 is a glucosyltransferase. Protein O-Glucosyltransferase 1 modifies Notch signaling by adding glucose to serine residues in Notch .

HY-P2729

Subtilisin EC 3.4.21.14	Biochemical Assay Reagents
Subtilisin, or rubinase, is a bacterial serine protease. Subtilisin can be used as a detergent additive with thermal stability, pH tolerance, and calcium dependent stability .

HY-P2948

*Protein serine/threonine kinase* Ser/Thr protein kinase	Biochemical Assay Reagents
Protein serine/threonine kinase (Ser/Thr protein kinase) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P2986

D-Amino acid oxidase	Biochemical Assay Reagents
D-Amino acid oxidase is an enzyme to metabolize exogenous D-amino acids in animals for detoxifying action. D-Amino acid oxidase also modulates the level of D-serine in brain .

HY-E70078

Cystathionine β-synthase	Biochemical Assay Reagents
Cystathionine β-synthase is an enzyme that catalyzes the condensation of serine and homocysteine to water and cystathionine. Cystathionine β-synthase is a prominent enzyme for the production of hydrogen sulfide (H₂S) .

HY-W087937

Benzamidine hydrochloride hydrate 2 Publications Verification Benzenecarboximidamide hydrochloride hydrate	Biochemical Assay Reagents
Benzamidine (Benzenecarboximidamide) hydrochloride hydrate is a reversible competitive *trypsin-like serine* proteases inhibitor with K_i**s of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively .

HY-155909

m-PEG-NHS ester (MW 3400) mPEG-SC (MW 3400); mPEG-Succinimidyl ester (MW 3400)	Drug Delivery
m-PEG-NHS ester (MW 3400) can be used to modify active molecules and improve their antigenicity, immunogenicity, and help prepare injection preparations. The modification of serine protease lumbrokinase (LK) by m-PEG-NHS ester does not affect its strong fibrinolytic and thrombolytic activities, and has good application prospects.

HY-155909A

m-PEG-NHS ester (MW 1000) mPEG-SC (MW 1000); mPEG-Succinimidyl ester (MW 1000)	Drug Delivery
m-PEG-NHS ester (MW 1000) can be used to modify active molecules and improve their antigenicity, immunogenicity, and help prepare injection preparations. The modification of serine protease lumbrokinase (LK) by m-PEG-NHS ester does not affect its strong fibrinolytic and thrombolytic activities, and has good application prospects.

HY-155909B

m-PEG-NHS ester (MW 550) mPEG-SC (MW 550); mPEG-Succinimidyl ester (MW 550)	Drug Delivery
m-PEG-NHS ester (MW 550) can be used to modify active molecules and improve their antigenicity, immunogenicity, and help prepare injection preparations. The modification of serine protease lumbrokinase (LK) by m-PEG-NHS ester does not affect its strong fibrinolytic and thrombolytic activities, and has good application prospects.

HY-155909C

m-PEG-NHS ester (MW 350) mPEG-SC (MW 350); mPEG-Succinimidyl ester (MW 350)	Drug Delivery
m-PEG-NHS ester (MW 350) can be used to modify active molecules and improve their antigenicity, immunogenicity, and help prepare injection preparations. The modification of serine protease lumbrokinase (LK) by m-PEG-NHS ester does not affect its strong fibrinolytic and thrombolytic activities, and has good application prospects.

HY-W591424

m-PEG-NHS ester (MW 2000) mPEG-SC (MW 2000); mPEG-Succinimidyl ester (MW 2000)	Drug Delivery
m-PEG-NHS ester (MW 2000) can be used to modify active molecules and improve their antigenicity, immunogenicity, and help prepare injection preparations. The modification of serine protease lumbrokinase (LK) by m-PEG-NHS ester does not affect its strong fibrinolytic and thrombolytic activities, and has good application prospects.

HY-108717

Proteinase K 5 Publications Verification Protease K	Biochemical Assay Reagents
Proteinase K (Protease K) is a nonspecific serine protease that is useful for general digestion of proteins. Proteinase K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Proteinase K can be use for promoting methods of viral nucleic acid extraction, and detection .

HY-P2969

Complement factor I	Biochemical Assay Reagents
Complement factor I is a serine protease that downregulates complement activity in the fluid phase and/or on cell surfaces in conjunction with one of its cofactors, factor H (FH), complement receptor 1 (CR1/CD35), C4 binding protein (C4BP) or membrane cofactor protein (MCP/CD46) .

HY-E70018

Picornain 3C

Biochemical Assay Reagents

Picornain 3C is a protease found in picornaviruses, which cleaves peptide bonds of non-terminal sequences. Picornain 3C is an intermediate between the serine peptidase chymotrypsin and the cysteine peptidase papain. Picornain 3C shows endopeptidase activity by selectively cleaving Gln-Gly bonds in the polyprotein of poliovirus and with substitution of Glu for Gln, and Ser or Thr for Gly in other picornaviruses .

HY-129047

Trypsin

4 Publications Verification

Biochemical Assay Reagents

Trypsin is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin activates PAR2 and PAR4. Trypsin induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin also promotes cell proliferation and differentiation. Trypsin can be used in the research of wound healing and neurogenic inflammation .

Cat. No.	Product Name	Target	Research Area

HY-W005308

*N-BOC-DL-serine* methyl ester**	Amino Acid Derivatives	Cancer
N-BOC-DL-serine methyl ester is a Serine derivative. N-BOC-DL-serine methyl ester is used for the synthesis of α,β-dehydro-α-amino acid. N-BOC-DL-serine methyl ester is also used for the synthesis of anti-cancer agent, such as quinazolinone derivative that inhibits PI3K activity, and tricyclic pyrolopyranopyridines that inhibits protein kinase activity .

HY-W003903A

Methyl benzyl-L-serinate

Peptides Others

Methyl benzyl-L-serinate is a serine derivative.

HY-W048674

Fmoc-Ser(Ac)-OH Fmoc-O-acetyl-L-serine	Amino Acid Derivatives	Infection
Fmoc-Ser(Ac)-OH (Fmoc-O-acetyl-L-serine) is a Serine derivative. Fmoc-Ser(Ac)-OH can be used for the preparation of broad-spectrum coronavirus membrane fusion inhibitor .

HY-P4706

Boc-Ala-Ala-pNA

Peptides Others

Boc-Ala-Ala-pNA is a serine peptidase

HY-P2942

Chymotrypsinogen	Ser/Thr Protease	Inflammation/Immunology
Chymotrypsinogen is an inactive precursor of Chymotrypsin (HY-108910). Chymotrypsin is a serine protease produced by the pancreas .

HY-W039102

N-Fmoc-N,O-dimethyl-L-serine	Amino Acid Derivatives	Cancer
N-Fmoc-N,O-dimethyl-L-serine is a serine derivative that can be used for coibamide A synthesis. Coibamide A is a marine natural product with potent antiproliferative activity against human cancer cells .

HY-P4484

Suc-AAPK-pNA

Peptides Others

Suc-AAPK-pNA is a chromogenic substrate for the determination of serine/threonine kinase activity and enzyme kinetic parameters .

HY-P4243

Dansyl-Glu-Gly-Arg-Chloromethylketone	Ser/Thr Protease	Others
Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor, and inhibits serine/threonine proteases. Dansyl-Glu-Gly-Arg-Chloromethylketone inhibits activated porcine factor IX .

HY-P2990

Enteropeptidase TMPRSS15	Ser/Thr Protease	Metabolic Disease
Enteropeptidase (TMPRSS15), a type II transmembrane serine protease and a physiological activator of trypsinogen. Enteropeptidase is associated with the brush border membrane (BBM) of the enterocytes in the upper small intestine. Trypsinogen is the primary substrate for Enteropeptidase. Enteropeptidase is involved in digestion in humans and animals .

HY-18234

Leupeptin	Ser/Thr Protease Virus Protease Cathepsin	Infection Inflammation/Immunology
Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits *serine, cysteine* and threonine proteases. Leupeptin inhibits M ^pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity .

HY-W053678

Benzyl-L-serine

Peptides Others

Benzyl-L-serine is a serine derivative .
HY-131894

DL-Serine hydroxamate

Amino Acid Derivatives Others

DL-Serine hydroxamate is a serine derivative .
HY-Z0711

L-Serine isopropyl ester hydrochloride

Amino Acid Derivatives Others

L-Serine isopropyl ester hydrochloride is a serine derivative .
HY-W009908

O-Benzyl-D-serine

Amino Acid Derivatives Others

O-Benzyl-D-serine is a serine derivative .
HY-W010156

O-(tert-Butyl)-L-serine

Amino Acid Derivatives Others

O-(tert-Butyl)-L-serine is a serine derivative .
HY-W002294

(tert-Butoxycarbonyl)-D-serine

Amino Acid Derivatives Others

(tert-Butoxycarbonyl)-D-serine is a serine derivative .
HY-W004064

N-Boc-O-Benzyl-D-serine

Amino Acid Derivatives Others

N-Boc-O-Benzyl-D-serine is a serine derivative .
HY-W142081

N-(2,4-Dinitrophenyl)-L-serine

Amino Acid Derivatives Others

N-(2,4-Dinitrophenyl)-L-serine is a serine derivative .
HY-W011354

O-tert-Butyl-N-carbobenzoxy-L-serine methyl ester

Amino Acid Derivatives Others

O-tert-Butyl-N-carbobenzoxy-L-serine methyl ester is a serine derivative .
HY-W013793

(((9H-Fluoren-9-yl)methoxy)carbonyl)-D-serine

Amino Acid Derivatives Others

(((9H-Fluoren-9-yl)methoxy)carbonyl)-D-serine is a serine derivative .
HY-W008977

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(phenylmethyl)-L-serine

Amino Acid Derivatives Others

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(phenylmethyl)-L-serine is a serine derivative .

HY-124081

N-Oleoyl-L-serine	Apoptosis	Metabolic Disease
N-Oleoyl-L-Serine is an endogenous amide of long-chain fatty acids with ethanolamine (N-acyl amides). N-Oleoyl-L-Serine is a lipid regulator of bone remodeling and stimulates osteoclast apoptosis. N-Oleoyl-L-Serine can be used for antiosteoporotic drug discovery development .

HY-W022226

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(phenylmethyl)-D-serine

Amino Acid Derivatives Others

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(phenylmethyl)-D-serine is a serine derivative .
HY-W072598

N-(tert-Butoxycarbonyl)-O-(tetrahydro-2H-pyran-2-yl)-L-serine

Amino Acid Derivatives Others

N-(tert-Butoxycarbonyl)-O-(tetrahydro-2H-pyran-2-yl)-L-serine is a serine derivative .

HY-W048693

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-O-(tert-butyldimethylsilyl)-L-serine	Amino Acid Derivatives	Others
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-O-(tert-butyldimethylsilyl)-L-serine is a serine derivative .

HY-W053702

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-O-trityl-D-serine

Amino Acid Derivatives Others

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-O-trityl-D-serine is a serine derivative .

HY-P5455

S3 Fragment	LIM Kinase (LIMK)	Others
S3 Fragment is a biological active peptide. (This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.)

HY-W008113

Boc-L-Homoserine

Amino Acid Derivatives Others

Boc-L-Homoserine is a serine derivative .
HY-W012967

L-Isoserine

Amino Acid Derivatives Others

L-Isoserine is a serine derivative .
HY-32688

Boc-Ser-OMe

Amino Acid Derivatives Others

Boc-Ser-OMe is a serine derivative .
HY-W017788

Boc-D-Homoserine

Amino Acid Derivatives Others

Boc-D-Homoserine is a serine derivative .
HY-W007720

Fmoc-Ser-OH

Amino Acid Derivatives Others

Fmoc-Ser-OH is a serine derivative .
HY-W007842

Z-Ser-OH

Amino Acid Derivatives Others

Z-Ser-OH is a serine derivative .
HY-W008179

Z-Ser-OMe

Amino Acid Derivatives Others

Z-Ser-OMe is a serine derivative .
HY-W041867

Boc-Ser-OtBu

Amino Acid Derivatives Others

Boc-Ser-OtBu is a serine derivative .
HY-W011443

Z-Ser-OtBu

Amino Acid Derivatives Others

Z-Ser-OtBu is a serine derivative .
HY-W041991

Fmoc-Ser-Obzl

Amino Acid Derivatives Others

Fmoc-Ser-Obzl is a serine derivative .
HY-W035886

Benzyl D-serinate hydrochloride

Amino Acid Derivatives Others

Benzyl D-serinate hydrochloride is a serine derivative .
HY-W016996

H-Ser-OEt.HCl

Amino Acid Derivatives Others

H-Ser-OEt.HCl is a serine derivative .
HY-22297

Fmoc-Ser-OtBu

Amino Acid Derivatives Others

Fmoc-Ser-OtBu is a serine derivative .

HY-W142092

N-Acetyl-DL-serine	Bacterial	Others
N-Acetyl-DL-serine is a hydrophobic amino acid that is synthesized in the body and can be found as a free form or as a salt with malonate, phosphate, or acetate. N-Acetyl-DL-serine has antimicrobial activity against Bacillus cereus and Staphylococcus aureus. N-Acetyl-DL-serine has also been used for the immobilization of DNA fragments on solid surfaces and can be used for protein synthesis and optical detection of DNA strands .

HY-W009770

H-Ser(tBu)-OMe.HCl

Amino Acid Derivatives Others

H-Ser(tBu)-OMe.HCl is a serine derivative .
HY-79877

Boc-Ser(Tos)-OMe

Amino Acid Derivatives Others

Boc-Ser(Tos)-OMe is a serine derivative .
HY-W007941

Fmoc-Ser(tBu)-OH

Amino Acid Derivatives Others

Fmoc-Ser(tBu)-OH is a serine derivative .
HY-W008308

H-Ser(Bzl)-OH

O-Benzyl-L-serine
Amino Acid Derivatives Others

H-Ser(Bzl)-OH is a serine derivative .
HY-W042010

H-D-Ser-OEt.HCl

Amino Acid Derivatives Others

H-D-Ser-OEt.HCl is a serine derivative .
HY-W008958

Fmoc-MeSer(Bzl)-OH

Amino Acid Derivatives Others

Fmoc-MeSer(Bzl)-OH is a serine derivative .
HY-W011255

Z-Ser(Bzl)-OH

Amino Acid Derivatives Others

Z-Ser(Bzl)-OH is a serine derivative .
HY-W011992

H-Ser(Bzl)-OMe.HCl

Amino Acid Derivatives Others

H-Ser(Bzl)-OMe.HCl is a serine derivative .
HY-W012104

Z-D-Ser-OH

Amino Acid Derivatives Others

Z-D-Ser-OH is a serine derivative .

Cat. No.	Product Name

HY-K0023

Phosphatase Inhibitor Cocktail III

205+ Cited Publications

Phosphatase Inhibitor Cocktail III effectively inhibits serine/threonine and alkaline phosphatases.

HY-K0021

Phosphatase Inhibitor Cocktail I 350+ Cited Publications
Phosphatase Inhibitor Cocktail I effectively inhibits alkaline phosphatases and serine/threonine protein phosphatases such as PP1 and PP2A.

HY-KE7057

O-Glycosidase
O-Glycosidase is highly specific and can release Galβ1-3GalNAc from serine, threonine residues or as part of a glycopeptide or glycoprotein. Applied to glycoprotein biosynthesis analysis, O-glycan bioactive protein O-glycosylation detection and binding site analysis.

Cat. No.	Product Name	Target	Research Area

HY-P99050

Sutimlimab	Complement System	Cardiovascular Disease Inflammation/Immunology
Sutimlimab, a first-in-class complement protein component 1, s subcomponent (C1s) inhibitor, can be used for the research of cold agglutinin disease. C1s is a serine protease which cleaves C4 and C2 to form the C3 convertase .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113013

Hydroxypyruvic acid β-Hydroxypyruvic acid; 3-Hydroxypyruvic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Hydroxypyruvic acid (β-Hydroxypyruvic acid) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.

HY-119759

Lipoxamycin	Infection Structural Classification Microorganisms Antifungal Classification of Application Fields Antibiotics Source classification Disease Research Disease Research Fields Other Antibiotics	Fungal
Lipoxamycin is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC₅₀ of 21 nM .

HY-N4332

Rivulariapeptolides 1121	Natural Products Microorganisms Source classification	Ser/Thr Protease
Rivulariapeptolides 1121 is a high potent and selective serine protease inhibitor with IC₅₀ values of 35.52 nM, 13.24 nM and 48.05 nM for chymotrypsin, elastase and proteinase K, respectively .

HY-113013A

Hydroxypyruvic acid lithium hydrate β-Hydroxypyruvic acid lithium hydrate; 3-Hydroxypyruvic acid lithium hydrate	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Hydroxypyruvic acid lithium hydrate (β-Hydroxypyruvic acid lithium hydrate) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid lithium hydrate is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid lithium hydrate is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.

HY-N4331

Rivulariapeptolides 1185	Natural Products Microorganisms Source classification	Ser/Thr Protease
Rivulariapeptolides 1185 is a high potent and selective serine protease inhibitor with IC₅₀ values of 13.17 nM, 23.59 nM and 55.26 nM for chymotrypsin, elastase and proteinase K, respectively .

HY-N4333

Rivulariapeptolides 988	Natural Products Microorganisms Source classification	Ser/Thr Protease
Rivulariapeptolides 988 is a high potent and selective serine protease inhibitor with IC₅₀ values of 95.46 nM, 15.29 nM and 85.50 nM for chymotrypsin, elastase and proteinase K, respectively .

HY-18234A

Leupeptin hemisulfate Maximum Cited Publications 29 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Cathepsin Ser/Thr Protease Virus Protease
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits *serine, cysteine* and threonine proteases. Leupeptin hemisulfate inhibits M ^pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity .

HY-N0650

L-Serine 3 Publications Verification Serine	Structural Classification Classification of Application Fields Anti-aging Source classification Endocrine diseases Amino acids Endogenous metabolite Microorganisms Disease markers Nervous System Disorder Disease Research Fields Cardiovascular System Disorder Cancer	Endogenous Metabolite Bacterial
L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-15129

O-Phospho-L-serine L-Serine O-phosphate; L-SOP	Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite	mGluR Endogenous Metabolite
O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2 .

HY-101409A

*O-Acetyl-L-serine* hydrochloride**	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
O-Acetyl-L-serine hydrochloride is an endogenous metabolite.

HY-15130

DL-O-Phosphoserine	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
DL-O-Phosphoserine, a normal metabolite in human biofluid, is an ester of serine and phosphoric acid.

HY-101409

O-Acetylserine O-Acetyl-L-serine	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Other Diseases Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
O-Acetylserine (O-Acetyl-L-serine) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants.

HY-126034

3,4-Dichloroisocoumarin	Structural Classification Animals Source classification Coumarins Phenylpropanoids	Ser/Thr Protease
3,4-Dichloroisocoumarin is a potent *serine-protease* inhibitor that inhibits chymotrypsin-like activity .

HY-139568

Deutarserine CTP-692	Structural Classification Neurological Disease Classification of Application Fields Source classification Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Deutarserine is a deuterium modified analog of endogenous D-serine (CTP 692), which is used in the research of adults with schizophrenia .

HY-N4330

Rivulariapeptolides 1155	Natural Products Microorganisms Source classification	Ser/Thr Protease
Rivulariapeptolides 1155 is a potent serine protease inhibitor with IC₅₀s of 41.84, 4.94, 56.54 nM for chymotrypsin, elastase, prpteinase K, respectively .

HY-134222A

N-Acetylserine N-Acetyl-L-serine	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N-Acetylserine (N-Acetyl-L-serine) can bind to CysB apoprotein. N-acetylserine is the physiological inducer of cysteine biosynthesis. N-Acetylserine can stimulate in vitro cysJIH transcription .

HY-P0219

Microcystin-LA	Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	Phosphatase
Microcystin LA, a natural toxin, exerts its cytotoxic exects by inhibiting the serine-threonine protein phosphatases PP1 and PP2A with IC₅₀s of 0.3 and 0.3 nM, respectively .

HY-N10223

Phostriecin	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Inflammation/Immunology Disease Research Fields Other Antibiotics	Antibiotic Phosphatase
Phostriecin is an antitumor antibiotic produced by Streptomyces pulveraceus. Phostriecin is a strong inhibitor of type 2A (PP2A) and a weak inhibitor of type 1 (PP1) serine/threonine protein phosphatases with IC₅₀s of 3.2 nM and 131 μM, respectively. Phostriecin has the potential for the research of cancer .

HY-N1996

Chebulagic acid 2 Publications Verification	Classification of Application Fields Combretaceae Source classification Phenols Polyphenols Terminalia chebula Retz. Plants Inflammation/Immunology Disease Research Fields	COX Lipoxygenase SARS-CoV Influenza Virus
Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis. Chebulagic acid is a *M2 serine* to asparagine 31 mutation (S31N) inhibitor and influenza antiviral. Chebulagic acid also against SARS-CoV-2 viral replication with an EC₅₀** of 9.76 μM.

HY-N6798

Myriocin 4 Publications Verification Thermozymocidin; ISP-I	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	HCV Antibiotic
Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC₅₀ of 3.5 µg/mL for inhibiting HCV infection .

Cat. No.	Product Name	Chemical Structure

HY-N0650S8

*L-Serine-d3*
L-Serine-d₃ is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S11

*L-Serine-d7*
L-Serine-d₇ is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S1

L-Serine-13C

L-Serine- ¹³C is the ¹³C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S7

*L-Serine-d2*
L-Serine-d₂ is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-W718796

*DL-Serine-15N*
DL-Serine- ¹⁵N is ¹⁵N-labeled DL-Serine (HY-Y0507) DL-Serine, a fundamental metabolite, is a mixture of D-Serine and L-Serine. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV).

HY-N0650S10

L-Serine-15N

L-Serine- ¹⁵N is the ¹⁵N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-Y0507S

*DL-Serine-2,3,3-d3*
DL-Serine-2,3,3-d₃ is the deuterium labeled DL-Serine. DL-Serine, a fundamental metabolite, is a mixture of D-Serine and L-Serine. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV)[1].

HY-N0650S

*L-Serine-13C3*
L-Serine- ¹³C₃ is the ¹³C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S2

*L-Serine-1-13C*
L-Serine-1- ¹³C is the ¹³C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S4

*L-Serine-2-13C*
L-Serine-2- ¹³C is the ¹³C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S5

*L-Serine-13C3,15N*
L-Serine- ¹³C₃, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S9

*L-Serine-15N,d3*
L-Serine- ¹⁵N,d₃ is the deuterium and ¹⁵N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S6

*L-Serine1-13C,15N*
L-Serine1- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-N0650S12

*L-Serine-d3,15n*
L-Serine- ¹⁵N,d₃ is the deuterium and ¹⁵N labeled L-Serine[1]. L-Serine ((-)-Serine;(S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation[2].

HY-N0650S3

*L-Serine-13C3,15N,d3*
L-Serine- ¹³C₃, ¹⁵N,d₃ is the deuterium, ¹³C-, and 15-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-15129S

*O-Phospho-L-serine-13C3,15N*
O-Phospho-L-serine- ¹³C₃, ¹⁵N is the ¹³C- and ¹⁵N-labeled O-Phospho-L-serine. O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2[1].

HY-100808S

D-Serine-d3

D-Serine-d₃ ((R)-Serine-d₃) is a deuterium labeled D-Serine (HY-100808). D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration .

HY-115435S

1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine-d54 sodium

1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine-d₅₄ (sodium) is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine.

HY-146820S

*1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phospho-L-serine-d7 sodium*
1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phospho-L-serine-d₇ (sodium) is deuterium labeled 1-Pentadecanoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (sodium).

HY-146861S

*1-Pentadecanoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-d5 sodium*
1-Pentadecanoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-d₅ (sodium) is deuterium labeled 1-Pentadecanoyl-2-hydroxy-sn-glycero-3-phospho-L-serine (sodium).

HY-146864S

*1-Nonadecanoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-d5 sodium*
1-Nonadecanoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-d₅ (sodium) is deuterium labeled 1-Nonadecanoyl-2-hydroxy-sn-glycero-3-phospho-L-serine (sodium).

HY-146865S

*1-Heptadecanoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-d5 sodium*
1-Heptadecanoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-d₅ (sodium) is deuterium labeled 1-Heptadecanoyl-2-hydroxy-sn-glycero-3-phospho-L-serine (sodium).

HY-146866S

*1-Heptadecanoyl-2-docosatetraenoyl-sn-glycero-3-phospho- L-serine-d5 sodium*
1-Heptadecanoyl-2-docosatetraenoyl-sn-glycero-3-phospho- L-serine-d₅ (sodium) is deuterium labeled 1-Heptadecanoyl-2-docosatetraenoyl-sn-glycero-3-phospho- L-serine (sodium).

HY-146868S

*1-Heptadecanoyl-2-oleoyl-sn-glycero-3-phospho- L-serine-d5 sodium*
1-Heptadecanoyl-2-oleoyl-sn-glycero-3-phospho- L-serine-d₅ (sodium) is deuterium labeled 1-Heptadecanoyl-2-oleoyl-sn-glycero-3-phospho- L-serine (sodium).

HY-146869S

*1-Heptadecanoyl-2-palmitoleoyl-sn-glycero-3-phospho- L-serine-d5 sodium*
1-Heptadecanoyl-2-palmitoleoyl-sn-glycero-3-phospho- L-serine-d₅ (sodium) is deuterium labeled 1-Heptadecanoyl-2-palmitoleoyl-sn-glycero-3-phospho- L-serine (sodium).

HY-146870S

*1-Heptadecanoyl-2-myristoleoyl-sn-glycero-3-phospho- L-serine-d5 sodium*
1-Heptadecanoyl-2-myristoleoyl-sn-glycero-3-phospho- L-serine-d₅ (sodium) is deuterium labeled 1-Heptadecanoyl-2-myristoleoyl-sn-glycero-3-phospho- L-serine (sodium).

HY-146867S

*1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero-3-phospho- L-serine-d5 sodium*
1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero-3-phospho- L-serine-d₅ (sodium) is deuterium labeled 1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero-3-phospho- L-serine (sodium).

HY-W007941S1

Fmoc-Ser(tBu)-OH-15N

Fmoc-Ser(tBu)-OH- ¹⁵N is the ¹⁵N labeled Fmoc-Ser(tBu)-OH[1]. Fmoc-Ser(tBu)-OH is a serine derivative[2].

HY-B0190S1

Nafamostat formate salt-13C6
Nafamostat formate salt- ¹³C₆ is the ¹³C labeled Nafamostat[1]. Nafamostat, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis. Nafamostat blocks activation of SARS-CoV-2[2][3][4][5].

HY-136433S

N,N'-Dinitrosopiperazine-d8
N,N'-Dinitrosopiperazine-d₈ is the deuterium labeled N,N'-Dinitrosopiperazine[1]. N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine;DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568[2].

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Remarks

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

serines

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Natural
Products