Rivulariapeptolides 1121 

Rivulariapeptolides 1121 is a high potent and selective serine protease inhibitor with IC₅₀ values of 35.52 nM, 13.24 nM and 48.05 nM for chymotrypsin, elastase and proteinase K, respectively^[1].

IC50: 35.52 nM (chymotrypsin); 13.24 nM (elastase) and 48.05 nM (proteinase K)^[1].

Rivulariapeptolides 1121 (0-3 μM, 40 min) has high potency and distinct selectivity with IC₅₀ values of 35.52 nM, 13.24 nM and 48.05 nM for chymotrypsin, elastase and proteinase K, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1122.31

C₅₆H₈₃N₉O₁₅

CCCC(N1[C@H](C(N[C@H](C(N[C@H](C(N/C(C(N[C@H]2CC[C@@H](O)[N@@]3C2=O)=O)=C\C)=O)[C@@H](C)OC([C@H](C(C)C)NC([C@H](CC4=CC=C(O)C=C4)N(C([C@@H]3CC(C)C)=O)C)=O)=O)=O)[C@H](OC([C@@H]5CCCN5C(CCC)=O)=O)C)=O)CCC1)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Raphael Reher, et al. Native metabolomics identifies the rivulariapeptolide family of protease inhibitors. Nat Commun. 2022 Aug 8;13(1):4619.  [Content Brief]