Rivulariapeptolides 1185 

Rivulariapeptolides 1185 is a high potent and selective serine protease inhibitor with IC₅₀ values of 13.17 nM, 23.59 nM and 55.26 nM for chymotrypsin, elastase and proteinase K, respectively^[1].

IC50: 13.17 nM (chymotrypsin); 23.59 nM (elastase) and 55.26 nM (proteinase K)^[1].

Rivulariapeptolides 1185 (0-3 μM, 40 min) has high potency and distinct selectivity with IC₅₀ values of 13.17 nM, 23.59 nM and 55.26 nM for chymotrypsin, elastase and proteinase K, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1186.39

C₆₁H₈₇N₉O₁₅

CCCC(N1[C@H](C(N[C@H](C(N[C@H](C(NC(C(N[C@H]2CC[C@@H](O)[N@@]3C2=O)=O)CC(C)C)=O)[C@@H](C)OC([C@H](C(C)C)NC([C@H](CC4=CC=C(O)C=C4)N(C([C@@H]3CC5=CC=CC=C5)=O)C)=O)=O)=O)[C@H](OC([C@@H]6CCCN6C(CCC)=O)=O)C)=O)CCC1)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Raphael Reher, et al. Native metabolomics identifies the rivulariapeptolide family of protease inhibitors. Nat Commun. 2022 Aug 8;13(1):4619.  [Content Brief]