1. Anti-infection
  2. Fungal
  3. Lipoxamycin

Lipoxamycin 

Cat. No.: HY-119759
Handling Instructions

Lipoxamycin is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM.

For research use only. We do not sell to patients.

Lipoxamycin Chemical Structure

Lipoxamycin Chemical Structure

CAS No. : 32886-15-0

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Description

Lipoxamycin is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM[1][2].

IC50 & Target

Serine palmitoyltransferase[1]

In Vitro

Lipoxamycin has antifungal activity against a panel of humanpathogenic fungi with better potency against some of the Candida species (MIC values, 0.25-16 µg/mL). Cryptococcus neoformans is the most sensitive organism, followed by various species of Candida. Other filamentous fungi are sensitive to the Lipoxamycin in disk diffusion assays[1].
Lipoxamycin has a long alkyl chain and an amino-containing polar head group. Lipoxamycin is on the same order of potency as the sphingofungins and also have potent activity against the mammalianenzyme[1].

In Vivo

Lipoxamycin is highly toxic in mice when applied subeutaneously or topically. Toxicity may be mechanism based, since studies with a Chinese hamster ovary cell mutant have shown that the serine palmitoyltransferase is an essential enzymein mammalian cells[1].

Molecular Weight

372.50

Formula

C₁₉H₃₆N₂O₅

CAS No.

32886-15-0

SMILES

O=C(N(O)CCC(CCCCCCC(CCCC(C)C)=O)=O)[[email protected]@H](N)CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

LipoxamycinFungalAntifungalyeastsserinepalmitoyltransferasemammalianInhibitorinhibitorinhibit

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Lipoxamycin
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