1. Anti-infection
  2. Fungal
  3. Lipoxamycin

Lipoxamycin 

Cat. No.: HY-119759
Handling Instructions

Lipoxamycin is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM.

For research use only. We do not sell to patients.

Lipoxamycin Chemical Structure

Lipoxamycin Chemical Structure

CAS No. : 32886-15-0

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Description

Lipoxamycin is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM[1][2].

IC50 & Target

Serine palmitoyltransferase[1]

In Vitro

Lipoxamycin has antifungal activity against a panel of humanpathogenic fungi with better potency against some of the Candida species (MIC values, 0.25-16 µg/mL). Cryptococcus neoformans is the most sensitive organism, followed by various species of Candida. Other filamentous fungi are sensitive to the Lipoxamycin in disk diffusion assays[1].
Lipoxamycin has a long alkyl chain and an amino-containing polar head group. Lipoxamycin is on the same order of potency as the sphingofungins and also have potent activity against the mammalianenzyme[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Lipoxamycin is highly toxic in mice when applied subeutaneously or topically. Toxicity may be mechanism based, since studies with a Chinese hamster ovary cell mutant have shown that the serine palmitoyltransferase is an essential enzymein mammalian cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

372.50

Formula

C₁₉H₃₆N₂O₅

CAS No.
SMILES

O=C(N(O)CCC(CCCCCCC(CCCC(C)C)=O)=O)[[email protected]@H](N)CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

LipoxamycinFungalAntifungalyeastsserinepalmitoyltransferasemammalianInhibitorinhibitorinhibit

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