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  2. Fungal
  3. Lipoxamycin hemisulfate

Lipoxamycin hemisulfate 

Cat. No.: HY-119759A Purity: 98.69%
Handling Instructions

Lipoxamycin hemisulfate is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM.

For research use only. We do not sell to patients.

Lipoxamycin hemisulfate Chemical Structure

Lipoxamycin hemisulfate Chemical Structure

CAS No. : 11075-87-9

Size Price Stock Quantity
5 mg USD 750 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1300 In-stock
Estimated Time of Arrival: December 31
25 mg USD 2500 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Lipoxamycin hemisulfate:

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Description

Lipoxamycin hemisulfate is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM[1][2].

IC50 & Target

Serine palmitoyltransferase[1]

In Vitro

Lipoxamycin has antifungal activity against a panel of humanpathogenic fungi with better potency against some of the Candida species (MIC values, 0.25-16 µg/mL). Cryptococcus neoformans is the most sensitive organism, followed by various species of Candida. Other filamentous fungi are sensitive to the Lipoxamycin in disk diffusion assays[1].
Lipoxamycin has a long alkyl chain and an amino-containing polar head group. Lipoxamycin is on the same order of potency as the sphingofungins and also have potent activity against the mammalianenzyme[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Lipoxamycin is highly toxic in mice when applied subeutaneously or topically. Toxicity may be mechanism based, since studies with a Chinese hamster ovary cell mutant have shown that the serine palmitoyltransferase is an essential enzymein mammalian cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

421.54

Formula

C₁₉H₃₆N₂O₅.₁/₂H₂O₄S

CAS No.
SMILES

OC[[email protected]@H](C(N(O)CCC(CCCCCCC(CCCC(C)C)=O)=O)=O)N.OS(O)(=O)=O.[1/2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 40 mg/mL (94.89 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3723 mL 11.8613 mL 23.7225 mL
5 mM 0.4745 mL 2.3723 mL 4.7445 mL
10 mM 0.2372 mL 1.1861 mL 2.3723 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 4 mg/mL (9.49 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.69%

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Keywords:

Lipoxamycin hemisulfateFungalAntifungalyeastsserinepalmitoyltransferasemammalianhemisulfateInhibitorinhibitorinhibit

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Lipoxamycin hemisulfate
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HY-119759A
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