1. Metabolic Enzyme/Protease
  2. Ser/Thr Protease
    PAI-1
  3. ZK824190

ZK824190 

Cat. No.: HY-126361
Handling Instructions

ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.

For research use only. We do not sell to patients.

ZK824190 Chemical Structure

ZK824190 Chemical Structure

CAS No. : 2254001-81-3

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Description

ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively[1].

IC50 & Target

IC50: 237 nM (uPA), 1600 nM (tPA), 1850 nM (Plasmin)[1]

In Vivo

ZK824190 (2 mg/kg; PO) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h)[1].

Animal Model: Rats with experimental autoimmune encephalomyelitis (EAE) model[1]
Dosage: 2 mg/kg (Pharmacokinetic Analysis)
Administration: PO
Result: Oral availability F = 55%; Cmax= 0.64 g/mL and AUC = 2.2 h*g/mL; T1/2=2.8 h.
Molecular Weight

414.40

Formula

C₂₂H₂₀F₂N₂O₄

CAS No.

2254001-81-3

SMILES

CC[[email protected]@H](OC1=NC(OC2=CC(C3=CC=CC(CN)=C3)=CC=C2)=C(F)C=C1F)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ZK824190ZK 824190ZK-824190Ser/Thr ProteasePAI-1Serine proteasesSerine endopeptidasesThreonine proteasesPlasminogen activator inhibitor-1uPAUrokinaseSerineproteaseplasminogenmultiple sclerosisInhibitorinhibitorinhibit

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ZK824190
Cat. No.:
HY-126361
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