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  4. SPT-IN-1

SPT-IN-1 (compound 1) is an orally active and potent SPT (serine palmitoyl transferase) inhibitor, with an IC50 of 5.19 nM for hSPT1. SPT-IN-1 can be used for type 2 diabetes and dyslipidemia research.

For research use only. We do not sell to patients.

SPT-IN-1 Chemical Structure

SPT-IN-1 Chemical Structure

CAS No. : 1933533-18-6

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Based on 1 publication(s) in Google Scholar

SPT-IN-1 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

SPT-IN-1 (compound 1) is an orally active and potent SPT (serine palmitoyl transferase) inhibitor, with an IC50 of 5.19 nM for hSPT1. SPT-IN-1 can be used for type 2 diabetes and dyslipidemia research[1].

IC50 & Target

IC50: 5.19 nM (hSPT1)[1]
In Vitro

SPT-IN-1 (compound 1) exhibits a dose-dependent inhibition of C14-serine incorporation into ceramide in MCF-7 cells, with EC50 of 0.98 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SPT-IN-1 Related Antibodies
In Vivo

SPT-IN-1 (compound 1) (Sprague Dawley rats, 0-60 mg/kg, Orally, twice daily for 7 days) dose-dependently reduces plasma ceramides, reduces triglycerides and raises HDL in cholesterol/cholic acid fed rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

364.44

Formula

C22H24N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCC(C1=CN2C=CN=C2C(C3=CC=C(CC(O)=O)C=C3)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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SPT-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPT-IN-11933533-18-6Othersorally activeserine palmitoyl transferase (SPT)MCF-7 cellstype 2 diabetesdyslipidemiaInhibitorinhibitorinhibit

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SPT-IN-1
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HY-125351
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