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SPT-IN-1 

Cat. No.: HY-125351
Handling Instructions

SPT-IN-1 (compound 1) is an orally active and potent SPT (serine palmitoyl transferase) inhibitor, with an IC50 of 5.19 nM for hSPT1. SPT-IN-1 can be used for type 2 diabetes and dyslipidemia research.

For research use only. We do not sell to patients.

SPT-IN-1 Chemical Structure

SPT-IN-1 Chemical Structure

CAS No. : 1933533-18-6

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Description

SPT-IN-1 (compound 1) is an orally active and potent SPT (serine palmitoyl transferase) inhibitor, with an IC50 of 5.19 nM for hSPT1. SPT-IN-1 can be used for type 2 diabetes and dyslipidemia research[1].

IC50 & Target

IC50: 5.19 nM (hSPT1)[1]

In Vitro

SPT-IN-1 (compound 1) exhibits a dose-dependent inhibition of C14-serine incorporation into ceramide in MCF-7 cells, with EC50 of 0.98 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SPT-IN-1 (compound 1) (Sprague Dawley rats, 0-60 mg/kg, Orally, twice daily for 7 days) dose-dependently reduces plasma ceramides, reduces triglycerides and raises HDL in cholesterol/cholic acid fed rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

364.44

Formula

C22H24N2O3

CAS No.
SMILES

CCCCCCC(C1=CN2C=CN=C2C(C3=CC=C(CC(O)=O)C=C3)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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SPT-IN-1
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HY-125351
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