1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
    GPCR/G Protein
    Metabolic Enzyme/Protease
  2. EGFR
    Ras
    Phosphatase
  3. Tyrphostin 8

Tyrphostin 8 

Cat. No.: HY-W174279
Handling Instructions

Tyrphostin 8 is a tyrosine kinase, with an IC50 of 560 μM for EGFR kinase. Tyrphostin 8 is also a GTPase inhibitor. Tyrphostin 8 can inhibit the protein serine/threonine phosphatase calcineurin (IC50=21 μM).

For research use only. We do not sell to patients.

Tyrphostin 8 Chemical Structure

Tyrphostin 8 Chemical Structure

CAS No. : 3785-90-8

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Description

Tyrphostin 8 is a tyrosine kinase, with an IC50 of 560 μM for EGFR kinase. Tyrphostin 8 is also a GTPase inhibitor. Tyrphostin 8 can inhibit the protein serine/threonine phosphatase calcineurin (IC50=21 μM)[1][2][3].

IC50 & Target[1][3]

EGFR

560 μM (IC50)

calcineuin phosphatase

21 μM (IC50)

In Vitro

Tyrphostin 8 (10-100 μM; pretreated for 20 min) blocks the Carbachol-initiated PKCδ tyrosine phosphorylation and ERK1/2 activation in parotid acinar cells[1].
Tyrphostin 8 (10-100 μM) produces a rapid and large increase in the basal O2 consumption of parotid acinar[1].
Tyrphostin 8 (10-100 μM) reduces the parotid ATP content by ∼90% at the concentration of 100 μM[1].
Tyrphostin 8 increases apical-to-basolateral transport of insulin-transferrin conjugate by enhancing transferrin receptor-mediated transcytosis in filter-grown Caco-2 cell monolayer[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Parotid acinar cells
Concentration: 10, 100 μM
Incubation Time: Pretreated for 20 min
Result: Reduced the increase in tyrosine phosphorylation of PKCδ initiated by carbachol.
Reduced the activation of ERK1/2 by carbachol.
In Vivo

Tyrphostin 8 improves the glucose-lowering effect of Insulin-transferrin in Streptozotocin-induced diabetic rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

170.17

Formula

C₁₀H₆N₂O

CAS No.
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Storage

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Tyrphostin 8
Cat. No.:
HY-W174279
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