3785-90-8
3785-90-8
Chemical Structure
Tyrphostin 8
- CAS No.: 3785-90-8
- Formula:C10H6N2O
- Molecular Weight:170.17
IUPAC Name: 2-(4-hydroxybenzylidene)malononitrile
InChIKey: FNCOVSWSZZVFBQ-UHFFFAOYSA-N
SMILES: C1=C(C=CC(=C1)O)C=C(C#N)C#N
Biological Activity: Tyrphostin 8 is a tyrosine kinase, with an IC50 of 560 μM for EGFR kinase. Tyrphostin 8 is also a GTPase inhibitor. Tyrphostin 8 can inhibit the protein serine/threonine phosphatase calcineurin (IC50=21 μM)[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tyrphostin 8 | 98.0% | Tyrphostin 8 is a tyrosine kinase, with an IC50 of 560 μM for EGFR kinase. Tyrphostin 8 is also a GTPase inhibitor. Tyrphostin 8 can inhibit the protein serine/threonine phosphatase calcineurin (IC50=21 μM). | ||||||||||||||||||||
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References
- [1]. Soltoff SP. Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J Biol Chem. 2004 Mar 19;279(12):10910-8. [Content Brief]
- [2]. Xia CQ, et, al. Tyrphostin-8 enhances transferrin receptor-mediated transcytosis in Caco-2- cells and inreases hypoglycemic effect of orally administered insulin-transferrin conjugate in diabetic rats. Pharm Res. 2001 Feb;18(2):191-5. [Content Brief]
- [3]. Martin BL. Inhibition of calcineurin by the tyrphostin class of tyrosine kinase inhibitors. Biochem Pharmacol. 1998 Aug 15;56(4):483-8. [Content Brief]
Keywords
