1. Immunology/Inflammation
  2. Complement System
  3. FD-IN-1

FD-IN-1 

Cat. No.: HY-128570
Handling Instructions

FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D (FD) inhibitor with an IC50 of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5 µM, respectively.

For research use only. We do not sell to patients.

FD-IN-1 Chemical Structure

FD-IN-1 Chemical Structure

CAS No. : 1646682-14-5

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Description

FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D (FD) inhibitor with an IC50 of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5 µM, respectively[1].

In Vitro

FD-IN-1 (Compound 12) exhibits functional inhibition of AP activation (IC50=0.26 μM) in vitro in a membrane attack complex (MAC) deposition assay using 50% human whole blood (WB)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

FD-IN-1 (Compound 12) demonstrates systemic suppression of AP activation in a lipopolysaccharide-induced alternative complement pathway (AP) activation model as well as local ocular suppression in intravitreal injection-induced AP activation model in mice expressing human FD[1].
FD-IN-1 (Compound 12) exhibits high oral bioavailability (C57BL6 mice 83%, Beagle dogs 70%) following oral administration (mice and dogs 10 mg/kg)[1].
FD-IN-1 (Compound 12) exhibits terminal elimination half-lives (C57BL6 mice 1.6 h and Beagle dogs 3.8 h) following intravenous administration (mice and dogs 1 mg/kg)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human FD knock-in mice [1]
Dosage: 3 and 10 mg/kg
Administration: Oral gavage
Result: The AP pathway was fully inhibited for up to 10 h at the 10 mg/kg dose.
Molecular Weight

377.43

Formula

C₂₃H₂₃NO₄

CAS No.

1646682-14-5

SMILES

O=C(O)CC1=CC=CC=C1OCC2=CC=CC(C3=CC([[email protected]](N)CO)=CC=C3)=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

FD-IN-1Complement SystemComplementfactor DFDpathwayAPimmunesystemInhibitorinhibitorinhibit

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FD-IN-1
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HY-128570
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