FD | MedChemExpress (MCE) Life Science Reagents

By Targets:	Acetyl-CoA Carboxylase (1) ADC Cytotoxin (1) Apoptosis (3) BCRP (1) Complement System (3) DNA/RNA Synthesis (1) Fluorescent Dye (8) HBV (2) HIV (2) Isotope-Labeled Compounds (3) Microtubule/Tubulin (1) mTOR (1) Nucleoside Antimetabolite/Analog (2) P-glycoprotein (1) PI3K (4) Pim (1)
By Research Areas:	Cancer (11) Infection (2) Inflammation/Immunology (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128570

FD-IN-1	Complement System	Inflammation/Immunology
FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D (FD) inhibitor with an IC₅₀ of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC₅₀s of 7.7 and 6.5 µM, respectively .

HY-133852A

FD-1080 free acid 1 Publications Verification	Fluorescent Dye	Others
FD-1080 free acid is a fluorophore with both excitation and emission in the NIR-II region (Ex=1064 nm, Em=1080 nm). FD-1080 free acid can be used for in vivo imaging .

HY-133852

FD-1080

Fluorescent Dye Others

FD-1080 is a fluorophore with both excitation and emission in the NIR-II region (Ex=1064 nm, Em=1080 nm). FD-1080 can be used for in vivo imaging .
HY-D2294

FD dye 7

Fluorescent Dye Others

FD dye 7 (compound 7) is an intermediate of heptamethacyanine dye fluorescent dye and can be used to synthesize dyes FD-1 and FD-2 .

FD-1080	Fluorescent Dye	Others
FD-1080 is a fluorophore with both excitation and emission in the NIR-II region (Ex=1064 nm, Em=1080 nm). FD-1080 can be used for in vivo imaging .

FD dye 7	Fluorescent Dye	Others
FD dye 7 (compound 7) is an intermediate of heptamethacyanine dye fluorescent dye and can be used to synthesize dyes FD-1 and FD-2 .

HY-155529

FD1024	Pim	Cancer
FD1024 is PIM inhibitor (IC₅₀s: 1.96, 38.9, 4.17 nM for PIM1, 2, 3). FD1024 can be used for research of acute myeloid leukemia. FD1024 has strong antiproliferative activity against the tested AML cell lines, with 0.16 μM, 0.12 μM, 1.05 μM, 1.39μM for EOL-1, MV-4-11, KG-1, MOLM-16 cells. FD1024 also has antitumor efficacy in mice .

HY-132231

FD223	PI3K Apoptosis	Cancer
FD223 is a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor. FD223 displays high potency (IC₅₀=1 nM) and good selectivity over other isoforms (IC₅₀s of 51 nM, 29 nM and 37 nM, respectively for α, β and γ). FD223 exhibits efficient inhibition of the proliferation of acute myeloid leukemia (AML) cell lines by suppressing p-AKT Ser473 thus causing G1 phase arrest during the cell cycle. FD223 has potential for the research of leukemia such as AML .

HY-155066

FD274	PI3K mTOR	Cancer
FD274 is a highly potent PI3K/mTOR dual inhibitor with IC₅₀s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR, respectively. FD274 exhibits significant anti-proliferation of AML cell lines (HL-60 and MOLM-16). FD274 demonstrates dose-dependent inhibition of tumor growth in the HL-60 xenograft model. FD274 has the potential for acute myeloid leukemia research .

HY-155180

FD2056	PI3K	Cancer
FD2056 is a potent and orally active PI3K inhibitor. FD2056 inhibits PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ with IC₅₀s of 0.30, 0.80, 1.10, 0.42 nM. FD2056 also inhibits CDK2-CyclinA2 and CDK4-CyclinD3 with IC₅₀ of 115.95 and 2782.15 nM. FD2056 inhibits breast cancer cell proliferation with IC₅₀s of 1.06, 0.04, 1.40 μM for MDA-MB-231, MDA-MB-468, MCF-7 cells. FD2056 also induces cancer apoptosis and inhibits tumor growth .

HY-155996

FD2157	PI3K Apoptosis	Cancer
FD2157 is a photosensitive PI3K inhibitor, with IC₅₀s of 43 nM, 83 nM, 84 nM, 14 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ respectively. FD2157 potently inhibits cancer cell proliferation and induces cell apoptosis when exposed to 365 nm UV light .

HY-128685

FD 12-9 Ac12Az9	P-glycoprotein BCRP	Cancer
FD 12-9 is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC₅₀s of 285 nM and 0.9 nM, respectively. Anti-glioblastoma activity .

HY-101748

Tegadifur

40497S; FD 1
Others Cancer

Tegadifur is a fluorine-containing and anti-metabolic agent.
HY-111223

Tralkoxydim

PP604; ICIA 0604; FD-4026
Acetyl-CoA Carboxylase Others

Tralkoxydim is a cyclohexanedione herbicide that inhibits Acetyl-CoA Carboxylase in corn .
HY-D0257

Tartrazine

Acid Yellow 23; FD&C Yellow No. 5
Fluorescent Dye Others

Tartrazine is a synthetic lemon yellow azo dye primarily used as a food coloring.

Tegadifur 40497S; FD 1	Others	Cancer
Tegadifur is a fluorine-containing and anti-metabolic agent.

Tralkoxydim PP604; ICIA 0604; FD-4026	Acetyl-CoA Carboxylase	Others
Tralkoxydim is a cyclohexanedione herbicide that inhibits Acetyl-CoA Carboxylase in corn .

Tartrazine Acid Yellow 23; FD&C Yellow No. 5	Fluorescent Dye	Others
Tartrazine is a synthetic lemon yellow azo dye primarily used as a food coloring.

HY-123630

Allura Red AC FD&C RED NO. 40; CI 16035	Fluorescent Dye	Others
Allura Red AC, a food colourant, is dark red and water-soluble powder or granules used in various applications, such as in drinks, syrups, sweets and cereals. Allura Red AC has the ability to quench the intrinsic fluorescence of HSA through static quenching .

HY-D0307A

Amaranth

Acid Red 27; Azorubin S; FD & C Red Dye No. 2
Fluorescent Dye Others

Amaranth is a dark red to purple azo dye used as a food dye and to color cosmetics.

Amaranth Acid Red 27; Azorubin S; FD & C Red Dye No. 2	Fluorescent Dye	Others
Amaranth is a dark red to purple azo dye used as a food dye and to color cosmetics.

HY-D0915

Brilliant Blue FCF 2 Publications Verification Acid Blue 9; FD&C Blue No. 1; E133	Fluorescent Dye	Others
Brilliant Blue FCF is an aromatic hydrocarbon, a synthetic dye produced from petroleum and used as a colorant for food and other substances. The solution has a maximum absorption at 628 nm.

HY-D0914

Fast Green FCF FD&C Green No. 3; Food green 3; C.I. 42053	Fluorescent Dye	Others
Fast Green FCF is a sea green triarylmethane food dye, with absorption maximum ranging from 622 to 626 nm. Fast Green FCF is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF is carcinogenic and acts as a presynaptic locus by inhibiting the release of neurotransmitters in the nervous system .

HY-148171

L-2'-Fd4C	HIV HBV DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection
L-2'-Fd4C, is an l-nucleoside analogue. L-2'-Fd4C has anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity .

HY-148172

L-Fd4A	HIV HBV Nucleoside Antimetabolite/Analog	Infection
L-Fd4A is an adenine derivative. L-Fd4A has anti-human immunodeficiency virus (HIV) (EC₅₀=1.5 μM) and anti-hepatitis B virus (HBV) (EC₅₀=1.7 μM) activity. L-Fd4A has low cytotoxicity .

HY-N3921

Gancaonin I	Others	Cancer
Gancaonin I, an Isoflavone, exhibits moderate inhibition on human carboxylesterase 2 (hCES2A) with IC₅₀ of 1.72 μM. Gancaonin I inhibits hCES2A-mediated fluorescein diacetate (FD) hydrolysis .

HY-N3329

Magnoloside A

Others Others

Magnoloside A (compound 4) is a main phenylethanoid glycoside in Houpo. Magnoloside A can be used in the research of functional dyspepsia (FD) .
HY-N0756

Bornyl acetate

Apoptosis Cancer

Bornyl acetate is a potent odorant, exhibiting one of the highest flavor dilution factor (FD factor). Bornyl acetate possesses anti-cancer activity .

Magnoloside A	Others	Others
Magnoloside A (compound 4) is a main phenylethanoid glycoside in Houpo. Magnoloside A can be used in the research of functional dyspepsia (FD) .

Bornyl acetate	Apoptosis	Cancer
Bornyl acetate is a potent odorant, exhibiting one of the highest flavor dilution factor (FD factor). Bornyl acetate possesses anti-cancer activity .

HY-134178S1

5-Fluorouridine 5'-triphosphate-13C,19F,d1	Isotope-Labeled Compounds	Others
5-Fluorouridine 5'-triphosphate- ¹³C, ¹⁹F,d₁ is deuterium and ¹³C-labeled 5-Fluorouridine 5'-triphosphate (HY-134178).

HY-102034

Complement factor D-IN-1	Complement System	Inflammation/Immunology
Complement factor D-IN-1 is a potent and selective small-molecule reversible factor d inhibitor, with IC₅₀s of 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively.

HY-B2089

Cinitapride
Cinitapride is a nonselective 5-HT1 and 5-HT4 receptors agonist and a 5-HT2 and D2 antagonist. Cinitapride can be used in functional dyspepsia (FD) and gastroesophageal reflux disease (GERD) research .

HY-122700

Factor D inhibitor 6	Complement System	Inflammation/Immunology
Factor D inhibitor 6 is a potent, highly selective and orally active factor D (FD) inhibitor with an IC₅₀ of 30 nM and a K_d of 6 nM. Factor D inhibitor 6 is inactive against factor B, lassical and lectin complement-pathway activation, and a broad assay panel of receptors, ion channels, kinases and proteases .

HY-15583S

Auristatin F-d8	Isotope-Labeled Compounds ADC Cytotoxin Microtubule/Tubulin	Cancer
Auristatin F-d₈ is deuterium labeled Auristatin F (HY-15583). Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) .

HY-14648S5

Dexamethasone-d3-1 Hexadecadrol-d₃-1; Prednisolone F-d₃-1	Isotope-Labeled Compounds	Cancer
Dexamethasone-d₃-1 (Hexadecadrol-d₃-1; Prednisolone F-d₃-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

Cat. No.	Product Name	Type

HY-D0257

Tartrazine

Acid Yellow 23; FD&C Yellow No. 5
Dyes

Tartrazine is a synthetic lemon yellow azo dye primarily used as a food coloring.

Tartrazine Acid Yellow 23; FD&C Yellow No. 5	Dyes
Tartrazine is a synthetic lemon yellow azo dye primarily used as a food coloring.

HY-123630

Allura Red AC FD&C RED NO. 40; CI 16035	Dyes
Allura Red AC, a food colourant, is dark red and water-soluble powder or granules used in various applications, such as in drinks, syrups, sweets and cereals. Allura Red AC has the ability to quench the intrinsic fluorescence of HSA through static quenching .

HY-D0307A

Amaranth

Acid Red 27; Azorubin S; FD & C Red Dye No. 2
Dyes

Amaranth is a dark red to purple azo dye used as a food dye and to color cosmetics.
HY-133852

FD-1080

Fluorescent Dyes/Probes

FD-1080 is a fluorophore with both excitation and emission in the NIR-II region (Ex=1064 nm, Em=1080 nm). FD-1080 can be used for in vivo imaging .
HY-D2294

FD dye 7

Dyes

FD dye 7 (compound 7) is an intermediate of heptamethacyanine dye fluorescent dye and can be used to synthesize dyes FD-1 and FD-2 .

Amaranth Acid Red 27; Azorubin S; FD & C Red Dye No. 2	Dyes
Amaranth is a dark red to purple azo dye used as a food dye and to color cosmetics.

FD-1080	Fluorescent Dyes/Probes
FD-1080 is a fluorophore with both excitation and emission in the NIR-II region (Ex=1064 nm, Em=1080 nm). FD-1080 can be used for in vivo imaging .

FD dye 7	Dyes
FD dye 7 (compound 7) is an intermediate of heptamethacyanine dye fluorescent dye and can be used to synthesize dyes FD-1 and FD-2 .

HY-D0915

Brilliant Blue FCF 2 Publications Verification Acid Blue 9; FD&C Blue No. 1; E133	Dyes
Brilliant Blue FCF is an aromatic hydrocarbon, a synthetic dye produced from petroleum and used as a colorant for food and other substances. The solution has a maximum absorption at 628 nm.

HY-D0914

Fast Green FCF FD&C Green No. 3; Food green 3; C.I. 42053	Dyes
Fast Green FCF is a sea green triarylmethane food dye, with absorption maximum ranging from 622 to 626 nm. Fast Green FCF is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF is carcinogenic and acts as a presynaptic locus by inhibiting the release of neurotransmitters in the nervous system .

Fast Green FCF

FD&C Green No. 3; Food green 3; C.I. 42053

Dyes

Fast Green FCF is a sea green triarylmethane food dye, with absorption maximum ranging from 622 to 626 nm. Fast Green FCF is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF is carcinogenic and acts as a presynaptic locus by inhibiting the release of neurotransmitters in the nervous system .

Cat. No.	Product Name	Target	Research Area

HY-P99120

Anti-Mouse CD11a Antibody (FD441.8)

Inhibitory Antibodies Inflammation/Immunology

Anti-Mouse CD11a Antibody is an anti-mouse CD11a IgG2b antibody inhibitor derived from the host Rat.

Anti-Mouse CD11a Antibody (FD441.8)	Inhibitory Antibodies	Inflammation/Immunology
Anti-Mouse CD11a Antibody is an anti-mouse CD11a IgG2b antibody inhibitor derived from the host Rat.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0756

Bornyl acetate	Classification of Application Fields Source classification Phenols Amomum villosum Lour. Plants Disease Research Fields Cancer Zingiberaceae	Apoptosis
Bornyl acetate is a potent odorant, exhibiting one of the highest flavor dilution factor (FD factor). Bornyl acetate possesses anti-cancer activity .

HY-N3329

Magnoloside A	Structural Classification Magnolia officinalis. Rehd. et Wils. Source classification Magnoliaceae Phenols Polyphenols Plants	Others
Magnoloside A (compound 4) is a main phenylethanoid glycoside in Houpo. Magnoloside A can be used in the research of functional dyspepsia (FD) .

Cat. No.	Product Name	Chemical Structure

HY-14648S5

Dexamethasone-d3-1
Dexamethasone-d₃-1 (Hexadecadrol-d₃-1; Prednisolone F-d₃-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

Dexamethasone-d3-1

Dexamethasone-d₃-1 (Hexadecadrol-d₃-1; Prednisolone F-d₃-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-134178S1

5-Fluorouridine 5'-triphosphate-13C,19F,d1

5-Fluorouridine 5'-triphosphate- ¹³C, ¹⁹F,d₁ is deuterium and ¹³C-labeled 5-Fluorouridine 5'-triphosphate (HY-134178).

5-Fluorouridine 5'-triphosphate-13C,19F,d1
5-Fluorouridine 5'-triphosphate- ¹³C, ¹⁹F,d₁ is deuterium and ¹³C-labeled 5-Fluorouridine 5'-triphosphate (HY-134178).

HY-15583S

Auristatin F-d8
Auristatin F-d₈ is deuterium labeled Auristatin F (HY-15583). Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) .

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FD

Inhibitors & Agonists

Fluorescent Dye

Inhibitory Antibodies

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Isotope-Labeled Compounds